Synthesis of new chiral 2,5-disubstituted 1,3,4-thiadiazoles possessing γ-butenolide moiety and preliminary evaluation of in vitro anticancer activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3340-3344

  Wei, Meng Xue ^a   Feng, Lei ^a   Li, Xue Qiang ^a   Zhou, Xue Zhang ^b   Shao, Zhi Hui ^c  

^a School of Chemistry and Chemical Engineering   (China)

^b Ministry of Education for Protection and Utilization of Special Biological Resources in Western Chin   (China)

^c YUNNAN UNIVERSITY   (China)

Author keywords

1,3,4 Thiadiazoles; Butenolide; Growth inhibitory; Hela cells; X ray crystallography

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; BUTENOLIDE; GAMMA BUTENOLIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN TISSUE; IC 50; X RAY CRYSTALLOGRAPHY;

4-BUTYROLACTONE; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DRUG DESIGN; HELA CELLS; HUMANS; STEREOISOMERISM; THIADIAZOLES;

EID: 67349184775     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.023     Document Type: Article

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