C825T G-protein β3 subunit gene polymorphism, tilt test results and point score in syncopal patients

Clinical Autonomic Research

Volumn 18, Issue 3, 2008, Pages 158-161

  Lelonek, Malgorzata ^a   Pietrucha, Tadeusz ^a   Matyjaszczyk, Monika ^a   Goch, Jan Henryk ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Gene polymorphism; Point score; Syncope; Tilting

Indexed keywords

G PROTEIN BETA3 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PROTEIN SUBUNIT;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; SCORING SYSTEM; SYNCOPE; TILT TABLE TEST;

ADULT; CASE-CONTROL STUDIES; DIZZINESS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; SYNCOPE; TILT-TABLE TEST;

EID: 44749095032     PISSN: 09599851     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10286-008-0474-z     Document Type: Article

References (27)

1. 2-adrenoceptor activation. Circ Res 85:965-969
2. Bourne HR (1997) How receptors talk to trimeric G proteins. Curr Opin Cell Biol 9:134-142
3. Benditt DG, Ermis C, Padanilam B, Samniah N, Sakaguchi S (2003) Catecholamine response during haemodynamically stable upright posture in individuals with and without tilt-table induced vasovagal syncope. Europace 5:65-70
4. Brignole M, Menozzi, Del Rosso A, Costa S, Gaggioli G, Bottoni N, Bartoli P, Sutton R (2000) New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglicerin challenge. Europace 2:66-76
5. Camfield PR, Camfield C (1990) Syncope in childhood: a case control clinical study of the family tendency to faint. Can J Neurol Sci 17:306-308
6. Del Rosso A, Bartoli P, Bartoletti A, Brandinelli-Geri A, Bonechi F, Maioli M, Mazza F, Michelucci A, Russo L, Salvetti E, Sansoni M, Zipoli A, Fierro A, Ieri A (1998) Shortened head-up tilt testing potentiated with sublingual nitroglycerin in patients with unexplained syncope. Am Heart J 135:564-570
7. 3-subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents. Circulation 102:692-697
8. Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP (2002) Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G (s) signaling during beta2-adrenergic stimulation. Circ Res 91:46-53
9. Kazemi B, Haghjoo M, Arya A, Sadr-Ameli MA (2006) Predictors of response to the head-up tilt test in patients with unexplained syncope or presyncope. Pacing Clin Electrophysiol 29:846-851
10. Kochiadakis GE, Papadimitriou EA, Marketou ME, Chrysostomakis SI, Simantirakis EN, Vardas PE (2004) Autonomic nervous system changes in vasovagal syncope: is there any difference between young and older patients? Pacing Clin Electrophysiol 27:1371-1377
11. Lelonek M, Pietrucha T, Matyjaszczyk M, Goch JH (2008) Mutation T/C,Ile 131 of the gene encoding the alfa subunit of the human Gs protein and predisposition to vasovagal syncope. Circ J 72:558-562
12. Lelonek M, Pietrucha T, Stanczyk A, Goch JH (2007) Vasovagal syncope patients and the C825T GNB3 polymorphism. Anadolu Kardiyol Derg 7(Suppl 1):206-208
13. Liao JK, Homcy CJ (1993) The release of endothelium-derived relaxing factor via alpha 2-adrenoceptor activation is specifically mediated by Gi alpha 2. J Biol Chem 268:19528-19533
14. Marquez MF, Hernandez-Pacheco G, Hermosillo AG, Gomez JR, Cardenas M, Vargas-Alarcon G (2007) The Arg389Gly B1-adrenergic receptor gene polymorphism and susceptibility to faint during head-up tilt test. Europace 9:585-588
15. Marquez MF, Urias KI, Hermosillo AG, Jardon JL, Iturralde P, Colin L, Nava S, Cardenas M (2005) Familial vasovagal syncope. Europace 7:472-474
16. Naber CK, Husing J, Wolfhard U, Erbel R, Siffert W (2000) Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction. Hypertension 36:986-989
17. Newton JL, Kenny R, Lawson J, Frearson R, Donaldson P (2003) Prevalence of familial history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives. Clin Auton Res 13:22-26
18. Newton JL, Kerr S, Pairman J, McLaren A, Norton M, Kenny RA, Morris CM (2005) Familial neurocardiogenic (vasovagal) syncope. Am J Med Genet A 133:176-179
19. Poch E, Gonzalez D, Gomez-Angelats E, Enjuto M, Pare JC, Rivera F, de La Sierra A (2000) G-protein beta (3) subunit gene variant and left ventricular hypertrophy in essential hypertension. Hypertension 35:214-218
20. Rosskopf D, Busch S, Manthey I, Siffert W (2000) G protein B3 gene. Structure, promoter, and additional polymorphisms. Hypertension 36:33-41
21. 2+ (2+)-exchanger. J Moll Cell Cardiol 36:43-48
22. Sheldon R, Rose S, Connolly S, Ritchie D, Koshman ML, Mrenneaux M, for the Syncope Symptom Study Investigators (2007) Diagnostic criteria for vasovagal syncope based on a quantitative history. Eur Heart J 27:344-350
23. Siffert W, Forster P, Jöckel KH, Mvere DA, Brinkmann B, Naber CH, Crookes R, Du P, Heyns A, Epplen JT, Fridey J, Freedman BI, Müller N, Stolke D, Sharma AM, Moutaery K, Grosse-Wilde H, Buerbaum B, Ehrlich T, Ahmad HR, Horsthemke B, Du Toit ED, Tiilikainen A, Ge J, Wang Y, Yang D, Hüsing J, Rosskopf D (1999) Worldwide ethnic distribution of the G protein B3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 10:1921-1930
24. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma A, Ritz E, Wichmann HE, Jakobs KH, Horsthemke B (1998) Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 18:45-48
25. Tabara Y, Kohara K, Miki T (2002) Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hhypotension. J Hypertens 20:651-656
26. Wallakut G (2002) The beta-adrenergic receptors. Herz 27:683-690
27. Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG (1999) Recent advances in cardiac beta (2)-adrenergic signal transduction. Circ Res 85:1092-1100