1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3356-3362

  Kumar, Vivek ^a,b   Jaggi, Manu ^a   Singh, Anu T ^a   Madaan, Alka ^a   Sanna, Vinod ^a   Singh, Pratibha ^a   Sharma, Pramod K ^b   Irchhaiya, Raghuveer ^b   Burman, Anand C ^a  

^a DABUR RESEARCH FOUNDATION   (India)

^b BUNDELKHAND UNIVERSITY   (India)

Author keywords

1,8 Naphthyridine; Anti inflammatory; Anti tumor

Indexed keywords

1,8 NAPHTHYRIDINE 3 CARBOXAMIDE DERIVATIVE; 1,8 NAPHTHYRIDINE DERIVATIVE; DOXORUBICIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

A549 CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; CELL STRAIN KB; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG CYTOTOXICITY; DRUG STRUCTURE; DU145 CELL; ENDOTHELIUM CELL; FIBROBLAST; HBL100 CELL; HUMAN; HUMAN CELL; IC 50; MIAPACA2 CELL; PA1 CELL; SW620 CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYTOKINES; DOWN-REGULATION; HUMANS; INFLAMMATION; INHIBITORY CONCENTRATION 50; MICE; NAPHTHYRIDINES;

EID: 67349135268     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.015     Document Type: Article

References (14)

1. Supuran C.T., and Scozzafava A. Expert Opin. Ther. Patents 14 (2004) 35-53
2. FDA News Drug Pipeline Alert 4 (March 21, 2006) 56
3. Burden D.A., and Oshereroff N. Biochim. Biophys. Acta 1400 (1998) 139-154
4. Tomita K., Tsuzuki Y., Shibamori K., Tashima M., Kajikawa F., Sato Y., Kashimoto S., Chiba K., and Hino K. J. Med. Chem. 45 (2002) 5564-5575
5. Tsuzuki Y., Tomita K., Shibamori K., Sato Y., Kashimoto S., and Chiba K. J. Med. Chem. 47 (2004) 2097-2109
6. Srivastava S.K., Jaggi M., Singh A.T., Madaan A., Rani N., Vishnoi M., Agarwal S.K., Mukherjee R., and Burman A.C. Bioorg. Med. Chem. Lett. 17 (2007) 6660-6664
7. Coussens L.M., and Werb Z. Nature 420 (2002) 860-867
8. Grossi G., Braccio M.D., Roma G., Ballabeni V., Tognolini M., and Barocelli E. Eur. J. Med. Chem. 40 (2005) 155-165
9. Dianzani C., Collino M., Gallicchio M., Braccio M.D., Roma G., and Fantozzi R. J. Inflamm. 4 (2006) 3
10. Mosmann T. J. Immunol. Methods 65 (1983) 55-63
11. Schlichting C.L., Schareck W.D., Nickel T., and Weis M. Curr. Med. Chem. 12 (2005) 1921-1930
12. Hackstein H., and Thomson A.W. Nat. Rev. Immunol. 4 (2004) 24-35
13. Song X.Y., Torphy T.J., Griswold D.E., and Shealy D. Mol. Interv. 2 (2002) 36-46
14. Lutz M.B., Kukutsch N., Ogilvie A.I., Koch S.F., and Schuler G. J. Immunol. Methods 223 (1999) 77-92