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Volumn 5, Issue 1, 2008, Pages

Targeted therapeutic strategies in malignant melanoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; BEVACIZUMAB; CARBOPLATIN; DACARBAZINE; INTERLEUKIN 2; IPILIMUMAB; LENALIDOMIDE; OBLIMERSEN; PACLITAXEL; PLACEBO; SORAFENIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; TICILIMUMAB;

EID: 67349106152     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2008.04.008     Document Type: Review
Times cited : (1)

References (53)
  • 2
    • 0031421593 scopus 로고    scopus 로고
    • Malignant melanoma: prognostic indicators
    • Ahmed I. Malignant melanoma: prognostic indicators. Mayo Clin. Proc. 72 (1997) 356-361
    • (1997) Mayo Clin. Proc. , vol.72 , pp. 356-361
    • Ahmed, I.1
  • 3
    • 0029065312 scopus 로고
    • Primary cutaneous melanoma: identification of prognostic groups and estimation of individual prognosis for 5093 patients
    • Garbe C., et al. Primary cutaneous melanoma: identification of prognostic groups and estimation of individual prognosis for 5093 patients. Cancer 75 (1995) 2484-2491
    • (1995) Cancer , vol.75 , pp. 2484-2491
    • Garbe, C.1
  • 4
    • 0003405566 scopus 로고
    • US Department of Health and Human Services pp. 92-278
    • Miller B., et al. Cancer Statistics Review: 1973-1989 (1992), US Department of Health and Human Services pp. 92-278
    • (1992) Cancer Statistics Review: 1973-1989
    • Miller, B.1
  • 5
    • 0029086370 scopus 로고
    • Prognostic factors in 1.521 melanoma patients with distant metastases
    • Barth A., et al. Prognostic factors in 1.521 melanoma patients with distant metastases. J. Am. Coll. Surg. 181 (1995) 193-201
    • (1995) J. Am. Coll. Surg. , vol.181 , pp. 193-201
    • Barth, A.1
  • 6
    • 0035880957 scopus 로고    scopus 로고
    • Prognostic factors analysis of 17,600 melanoma patients, validation of the American Joint Committee on Cancer melanoma staging system
    • Balch C.M., et al. Prognostic factors analysis of 17,600 melanoma patients, validation of the American Joint Committee on Cancer melanoma staging system. J. Clin. Oncol. 19 (2001) 3622-3634
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3622-3634
    • Balch, C.M.1
  • 7
    • 0026664267 scopus 로고
    • Disseminated melanoma: is there a new standard therapy?
    • Guerry D., and Schuchter L.M. Disseminated melanoma: is there a new standard therapy?. N. Engl. J. Med. 327 (1992) 560-561
    • (1992) N. Engl. J. Med. , vol.327 , pp. 560-561
    • Guerry, D.1    Schuchter, L.M.2
  • 8
    • 0036119064 scopus 로고    scopus 로고
    • Is there a standard for the palliative treatment of melanoma?
    • Schadendorf D. Is there a standard for the palliative treatment of melanoma?. Onkologie 25 (2002) 74-76
    • (2002) Onkologie , vol.25 , pp. 74-76
    • Schadendorf, D.1
  • 9
    • 0347503603 scopus 로고    scopus 로고
    • Palliative therapy of disseminated malignant melanoma: a systemic review of 41 randomised clinical trials
    • Eigentler T.K., et al. Palliative therapy of disseminated malignant melanoma: a systemic review of 41 randomised clinical trials. Lancet Oncol. 4 (2003) 748-759
    • (2003) Lancet Oncol. , vol.4 , pp. 748-759
    • Eigentler, T.K.1
  • 10
    • 22744447065 scopus 로고    scopus 로고
    • Novel agents in development for treatment of melanoma
    • Tarhini A.A., and Agarwala S.S. Novel agents in development for treatment of melanoma. Expert Opin. Investig. Drugs 14 (2005) 885-892
    • (2005) Expert Opin. Investig. Drugs , vol.14 , pp. 885-892
    • Tarhini, A.A.1    Agarwala, S.S.2
  • 11
    • 33644811013 scopus 로고    scopus 로고
    • Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma: a randomized, phase III, multicenter study from the Dermatologic Cooperative Oncology Group
    • Kaufmann R., et al. Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma: a randomized, phase III, multicenter study from the Dermatologic Cooperative Oncology Group. J. Clin. Oncol. 23 (2005) 9001-9007
    • (2005) J. Clin. Oncol. , vol.23 , pp. 9001-9007
    • Kaufmann, R.1
  • 12
    • 0028216334 scopus 로고
    • Thalidomide is an inhibitor of angiogenesis
    • D'Amato R.J., et al. Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. Sci. 91 (1994) 4082-4085
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 4082-4085
    • D'Amato, R.J.1
  • 13
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity by thalidomide through suppression of IκB kinase activity
    • Keifer J.A., et al. Inhibition of NF-κB activity by thalidomide through suppression of IκB kinase activity. J. Biol. Chem. 276 (2001) 22382-22387
    • (2001) J. Biol. Chem. , vol.276 , pp. 22382-22387
    • Keifer, J.A.1
  • 14
    • 0036381106 scopus 로고    scopus 로고
    • Thalidomide and its analogous have distinct and opposing effects on TNF-α and TNFR2 during costimulation of both CD4(+) and CD8(+) T cells
    • Marriott J.B., et al. Thalidomide and its analogous have distinct and opposing effects on TNF-α and TNFR2 during costimulation of both CD4(+) and CD8(+) T cells. Clin. Exp. Immunol. 130 (2002) 75-84
    • (2002) Clin. Exp. Immunol. , vol.130 , pp. 75-84
    • Marriott, J.B.1
  • 15
    • 13544275854 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic malignant melanoma
    • Reiriz A.B., et al. Phase II study of thalidomide in patients with metastatic malignant melanoma. Melanoma Res. 14 (2004) 527-531
    • (2004) Melanoma Res. , vol.14 , pp. 527-531
    • Reiriz, A.B.1
  • 16
    • 1642361149 scopus 로고    scopus 로고
    • Phase II study of thalidomide in patients with metastatic malignant melanoma
    • Pawlak W.Z., and Legha S.S. Phase II study of thalidomide in patients with metastatic malignant melanoma. Melanoma Res. 14 (2004) 57-62
    • (2004) Melanoma Res. , vol.14 , pp. 57-62
    • Pawlak, W.Z.1    Legha, S.S.2
  • 17
    • 0141688331 scopus 로고    scopus 로고
    • Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma
    • Hwu W.J., et al. Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma. J. Clin. Oncol. 21 (2003) 3351-3356
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3351-3356
    • Hwu, W.J.1
  • 18
    • 0037676126 scopus 로고    scopus 로고
    • Randomized phase II study of temozolomide given every 8 h or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma
    • Danson S., et al. Randomized phase II study of temozolomide given every 8 h or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma. J. Clin. Oncol. 21 (2003) 2551-2557
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2551-2557
    • Danson, S.1
  • 19
    • 20444387198 scopus 로고    scopus 로고
    • Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study
    • Hwu W.J., et al. Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study. Cancer 103 (2005) 2590-2597
    • (2005) Cancer , vol.103 , pp. 2590-2597
    • Hwu, W.J.1
  • 20
    • 33750067977 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102)
    • Krown S.E., et al. Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102). Cancer 107 (2006) 1883-1890
    • (2006) Cancer , vol.107 , pp. 1883-1890
    • Krown, S.E.1
  • 21
    • 11144355748 scopus 로고    scopus 로고
    • Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers
    • Bartlett J.B., et al. Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers. Br. J. Cancer 90 (2004) 955-961
    • (2004) Br. J. Cancer , vol.90 , pp. 955-961
    • Bartlett, J.B.1
  • 22
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber H.P., and Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 64 (2005) 671-680
    • (2005) Cancer Res. , vol.64 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 23
    • 34547451603 scopus 로고    scopus 로고
    • A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma
    • Varker K.A., et al. A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma. Ann. Surg. Oncol. 14 (2007) 2367-2376
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 2367-2376
    • Varker, K.A.1
  • 24
    • 0033119372 scopus 로고    scopus 로고
    • BCL-2 gene family and the regulation of programmed cell death
    • Korsmeyer S.J. BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 59 (1999) 1693-1700
    • (1999) Cancer Res. , vol.59 , pp. 1693-1700
    • Korsmeyer, S.J.1
  • 25
    • 0031907428 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy chemosensitizes melanoma in SCID mice
    • Jansen B., et al. Bcl-2 antisense therapy chemosensitizes melanoma in SCID mice. Nat. Med. 4 (1998) 232-234
    • (1998) Nat. Med. , vol.4 , pp. 232-234
    • Jansen, B.1
  • 26
    • 1642515793 scopus 로고    scopus 로고
    • Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma
    • Miller A., et al. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res. 64 (2004) 509
    • (2004) Cancer Res. , vol.64 , pp. 509
    • Miller, A.1
  • 27
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by BCL2 antisense therapy
    • Jansen B., et al. Chemosensitisation of malignant melanoma by BCL2 antisense therapy. Lancet 356 (2000) 1728-1733
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1
  • 28
    • 14144254200 scopus 로고    scopus 로고
    • Apoptosis, Bcl-2 antisense, and cancer therapy
    • Piro L.D. Apoptosis, Bcl-2 antisense, and cancer therapy. Oncology 18 (2004) 5-10
    • (2004) Oncology , vol.18 , pp. 5-10
    • Piro, L.D.1
  • 29
    • 28844454167 scopus 로고    scopus 로고
    • Antisense strategies for oncogene inactivation
    • Stein C.A., et al. Antisense strategies for oncogene inactivation. Semin. Oncol. 32 (2005) 563-572
    • (2005) Semin. Oncol. , vol.32 , pp. 563-572
    • Stein, C.A.1
  • 30
    • 17844374616 scopus 로고    scopus 로고
    • Improving outcomes in advanced malignant melanoma: update on systemic therapy
    • Danson S., and Lorigan P. Improving outcomes in advanced malignant melanoma: update on systemic therapy. Drugs 65 (2005) 733-743
    • (2005) Drugs , vol.65 , pp. 733-743
    • Danson, S.1    Lorigan, P.2
  • 31
    • 0038004544 scopus 로고    scopus 로고
    • Systemic treatment in advanced melanoma: innovative perspectives
    • Ugurel S., and Schadendorf D. Systemic treatment in advanced melanoma: innovative perspectives. Onkologie 26 (2003) 234-238
    • (2003) Onkologie , vol.26 , pp. 234-238
    • Ugurel, S.1    Schadendorf, D.2
  • 32
    • 0035874979 scopus 로고    scopus 로고
    • A novel N-ras mutation in malignant melanoma is associated with excellent prognosis
    • Demunter A., et al. A novel N-ras mutation in malignant melanoma is associated with excellent prognosis. Cancer Res. 61 (2001) 4916-4922
    • (2001) Cancer Res. , vol.61 , pp. 4916-4922
    • Demunter, A.1
  • 33
    • 17744388986 scopus 로고    scopus 로고
    • The role of B-RAF in melanoma
    • Gray-Schopfer V.C., et al. The role of B-RAF in melanoma. Cancer Metast. Rev. 24 (2005) 165-183
    • (2005) Cancer Metast. Rev. , vol.24 , pp. 165-183
    • Gray-Schopfer, V.C.1
  • 34
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H., et al. Mutations of the BRAF gene in human cancer. Nature 417 (2002) 949-954
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1
  • 35
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit D.B., et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 439 (2006) 358-362
    • (2006) Nature , vol.439 , pp. 358-362
    • Solit, D.B.1
  • 36
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin J.A., et al. Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353 (2005) 2135-2147
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2135-2147
    • Curtin, J.A.1
  • 37
    • 4944249117 scopus 로고    scopus 로고
    • BAY43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., et al. BAY43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 (2004) 7099-7109
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1
  • 38
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY-43-9006 in patients with advanced refractory solid tumors
    • Strumberg D., et al. Phase I clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY-43-9006 in patients with advanced refractory solid tumors. J. Clin. Oncol. 23 (2005) 695-972
    • (2005) J. Clin. Oncol. , vol.23 , pp. 695-972
    • Strumberg, D.1
  • 39
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis
    • Eisen T., et al. Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis. Br. J. Cancer 95 (2006) 581-586
    • (2006) Br. J. Cancer , vol.95 , pp. 581-586
    • Eisen, T.1
  • 40
    • 16844376769 scopus 로고    scopus 로고
    • Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma
    • Flaherty K., et al. Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma. Proc. Am. Soc. Clin. Oncol. 22 (2004) 711
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 711
    • Flaherty, K.1
  • 41
    • 27744565979 scopus 로고    scopus 로고
    • Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin
    • Molhoek K.R., et al. Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor rapamycin. J. Transl. Med. 3 (2005) 39
    • (2005) J. Transl. Med. , vol.3 , pp. 39
    • Molhoek, K.R.1
  • 42
    • 1642569629 scopus 로고    scopus 로고
    • New molecular targets in melanoma
    • Flaherty K.T. New molecular targets in melanoma. Curr. Opin. Oncol. 16 (2004) 150-154
    • (2004) Curr. Opin. Oncol. , vol.16 , pp. 150-154
    • Flaherty, K.T.1
  • 43
    • 33644798247 scopus 로고    scopus 로고
    • CTLA-4 blockade: autoimmunity as treatment
    • Kapadia D., and Fong L. CTLA-4 blockade: autoimmunity as treatment. J. Clin. Oncol. 23 (2005) 8926-8928
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8926-8928
    • Kapadia, D.1    Fong, L.2
  • 44
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4 mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy
    • Chambers C.A., et al. CTLA-4 mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19 (2001) 565-594
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 565-594
    • Chambers, C.A.1
  • 45
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3 (1995) 541-547
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 46
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach D., et al. Enhancement of antitumor immunity by CTLA-4 blockade. Science 271 (1996) 1734-1736
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.1
  • 47
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz A.A., et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res. 60 (2000) 2444-2448
    • (2000) Cancer Res. , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1
  • 48
    • 0003311698 scopus 로고    scopus 로고
    • MDX-010 (human anti-CTLA4): a phase I trial in malignant melanoma
    • abstract 74
    • Tchekmeddyian S., et al. MDX-010 (human anti-CTLA4): a phase I trial in malignant melanoma. J. Clin. Oncol. 21 (2002) 21 abstract 74
    • (2002) J. Clin. Oncol. , vol.21 , pp. 21
    • Tchekmeddyian, S.1
  • 49
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi F.S., et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4712-4717
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4712-4717
    • Hodi, F.S.1
  • 50
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • Attia P., et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J. Clin. Oncol. 23 (2005) 6043-6053
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6043-6053
    • Attia, P.1
  • 51
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study
    • Maker A.V., et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann. Surg. Oncol. 12 (2005) 1005-1016
    • (2005) Ann. Surg. Oncol. , vol.12 , pp. 1005-1016
    • Maker, A.V.1
  • 52
    • 20044395957 scopus 로고    scopus 로고
    • Autoimmunity in a phase I trial of fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
    • Sanderson K., et al. Autoimmunity in a phase I trial of fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. J. Clin. Oncol. 23 (2005) 741-750
    • (2005) J. Clin. Oncol. , vol.23 , pp. 741-750
    • Sanderson, K.1
  • 53
    • 32644467549 scopus 로고    scopus 로고
    • Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte associate antigen-4 monoclonal antibody CP-675206
    • Ribas A., et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte associate antigen-4 monoclonal antibody CP-675206. J. Clin. Oncol. 23 (2005) 8968-8977
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8968-8977
    • Ribas, A.1


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