메뉴 건너뛰기




Volumn 65, Issue 6, 2005, Pages 733-743

Improving outcomes in advanced malignant melanoma: Update on systemic therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; ANTISENSE OLIGONUCLEOTIDE; B RAF KINASE; BCG VACCINE; BENZYLGUANINE; BEVACIZUMAB; CANCER TESTIS ANTIGEN; CANCER VACCINE; CARBOPLATIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DACARBAZINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EPITOPE; FOTEMUSTINE; GANGLIOSIDE; GANGLIOSIDE GM2; GLYCOPROTEIN GP 100; GLYCOPROTEIN GP 96; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANINE DERIVATIVE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN GLYCOPROTEIN GP 96 COMPLEX; HISTAMINE; IMATINIB; IMIQUIMOD; INTERFERON; INTERLEUKIN 2; IPILIMUMAB; LENALIDOMIDE; LOMEGUATRIB; MELACINE; MELAN A; MELANOMA ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY LM 609; MONOPHENOL MONOOXYGENASE; NITROSOUREA DERIVATIVE; OBLIMERSEN; PACLITAXEL; PEPTIDE DERIVATIVE; PLACEBO; PLATINUM DERIVATIVE; PROTEIN NY ESO 1; RESIQUIMOD; SEMAXANIB; SORAFENIB; TAXANE DERIVATIVE; TEMOZOLOMIDE; THALIDOMIDE; TRASTUZUMAB; UNCLASSIFIED DRUG; VINCA ALKALOID; VIRUS RNA; VITRONECTIN RECEPTOR ANTIBODY; X LINKED INHIBITOR OF APOPTOSIS;

EID: 17844374616     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-200565060-00002     Document Type: Review
Times cited : (39)

References (91)
  • 1
    • 0041412922 scopus 로고    scopus 로고
    • Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997: Rising trends in incidence and mortality but recent stabilisations in Western Europe and decreases in Scandanavia
    • De Vries E, Bray FI, Coebergh JW, et al. Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997: rising trends in incidence and mortality but recent stabilisations in Western Europe and decreases in Scandanavia. Int J Cancer 2003; 107 (1): 119-26
    • (2003) Int J Cancer , vol.107 , Issue.1 , pp. 119-126
    • De Vries, E.1    Bray, F.I.2    Coebergh, J.W.3
  • 2
    • 0037167236 scopus 로고    scopus 로고
    • Incidence of and survival from malignant melanoma in Scotland: An epidemiological study
    • MacKie RM, Bray CA, Hole DJ, et al. Incidence of and survival from malignant melanoma in Scotland: an epidemiological study. Lancet 2002; 360: 587-91
    • (2002) Lancet , vol.360 , pp. 587-591
    • MacKie, R.M.1    Bray, C.A.2    Hole, D.J.3
  • 4
    • 0001325193 scopus 로고
    • Trends in skin cancer in Australia: An overview of the available data
    • Giles D, Dwyer T, Coates M, et al. Trends in skin cancer in Australia: an overview of the available data. Trans Menzies Found 1989; 15: 143-7
    • (1989) Trans Menzies Found , vol.15 , pp. 143-147
    • Giles, D.1    Dwyer, T.2    Coates, M.3
  • 5
    • 3042581118 scopus 로고    scopus 로고
    • Surgical excision of distant metastases
    • Balch C, Houghton A, Sober A, et al., editors. St Louis (MO): Quality Medical Publishing
    • Morton DL, Essner R, Calch C. Surgical excision of distant metastases. In: Balch C, Houghton A, Sober A, et al., editors. Cutaneous melanoma. 4th ed. St Louis (MO): Quality Medical Publishing, 2003: 547-72
    • (2003) Cutaneous Melanoma. 4th Ed. , pp. 547-572
    • Morton, D.L.1    Essner, R.2    Calch, C.3
  • 6
    • 0035881074 scopus 로고    scopus 로고
    • Final version of the American Joint Committee on Cancer staging for cutaneous melanoma
    • Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging for cutaneous melanoma. J Clin Oncol 2001; 19: 3635-48
    • (2001) J Clin Oncol , vol.19 , pp. 3635-3648
    • Balch, C.M.1    Buzaid, A.C.2    Soong, S.J.3
  • 7
    • 0033989205 scopus 로고    scopus 로고
    • Randomised phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic melanoma
    • Middleton MR, Grob JJ, Aaronson N, et al. Randomised phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic melanoma. J Clin Oncol 2000; 18: 158-66
    • (2000) J Clin Oncol , vol.18 , pp. 158-166
    • Middleton, M.R.1    Grob, J.J.2    Aaronson, N.3
  • 8
    • 17844373954 scopus 로고    scopus 로고
    • Randomised multinational phase 3 trial of dacarbazine with or without bcl-2 antisense (oblimersan sodium) in patients with advanced malignant melanoma: Analysis of long-term survival
    • Millward MJ, Bedikian AY, Conry RM, et al. Randomised multinational phase 3 trial of dacarbazine with or without bcl-2 antisense (oblimersan sodium) in patients with advanced malignant melanoma: analysis of long-term survival [abstract no. 7505]. Proc Am Soc Clin Oncol 2004; 22 (145): 22
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 22
    • Millward, M.J.1    Bedikian, A.Y.2    Conry, R.M.3
  • 10
    • 0021320381 scopus 로고
    • Randomised phase III trial of vinblastine, bleomycin and cis-dichlorodiamine-platinum versus dacarbazine in malignant melanoma
    • Luikart SD, Kennealey GT, Kirkwood JM. Randomised phase III trial of vinblastine, bleomycin and cis-dichlorodiamine-platinum versus dacarbazine in malignant melanoma. J Clin Oncol 1984; 2: 164-8
    • (1984) J Clin Oncol , vol.2 , pp. 164-168
    • Luikart, S.D.1    Kennealey, G.T.2    Kirkwood, J.M.3
  • 11
    • 0032858487 scopus 로고    scopus 로고
    • Phase III multicentre randomised trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma
    • Chapman PB, Einhorn LH, Meyers ML, et al. Phase III multicentre randomised trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 1999; 17: 2745-51
    • (1999) J Clin Oncol , vol.17 , pp. 2745-2751
    • Chapman, P.B.1    Einhorn, L.H.2    Meyers, M.L.3
  • 12
    • 0034052426 scopus 로고    scopus 로고
    • A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma
    • Middleton M, Lorigan P, Owen J, et al. A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma. Br J Cancer 2000 82: 1158-62
    • (2000) Br J Cancer , vol.82 , pp. 1158-1162
    • Middleton, M.1    Lorigan, P.2    Owen, J.3
  • 13
    • 0031064517 scopus 로고    scopus 로고
    • The role of interferon alpha in the treatment of metastatic melanoma
    • Legha SS. The role of interferon alpha in the treatment of metastatic melanoma. Semin Oncol 1997; 24 (4 Suppl.): S24-31
    • (1997) Semin Oncol , vol.24 , Issue.4 SUPPL.
    • Legha, S.S.1
  • 14
    • 0036137546 scopus 로고    scopus 로고
    • Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma
    • Agarwala SS, Glaspy J, O'Day SJ, et al. Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma. J Clin Oncol 2002; 20: 125-33
    • (2002) J Clin Oncol , vol.20 , pp. 125-133
    • Agarwala, S.S.1    Glaspy, J.2    O'Day, S.J.3
  • 15
    • 0033024863 scopus 로고    scopus 로고
    • High dose recombinant interleukin-2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, et al. High dose recombinant interleukin-2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999; 17: 2105-16
    • (1999) J Clin Oncol , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 16
    • 8244253669 scopus 로고    scopus 로고
    • Prospective randomised trial of lisofylline for the prevention of toxicities of high dose interleukin-2 therapy in advanced renal cancer and malignant melanoma
    • Margolin K, Atkins M, Sparano J, et al. Prospective randomised trial of lisofylline for the prevention of toxicities of high dose interleukin-2 therapy in advanced renal cancer and malignant melanoma. Clin Cancer Res 1997; 3: 365-72
    • (1997) Clin Cancer Res , vol.3 , pp. 365-372
    • Margolin, K.1    Atkins, M.2    Sparano, J.3
  • 17
    • 0025837770 scopus 로고
    • Improved results with the addition of interferon alpha-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma
    • Falkson C, Falkson G, Falkson H. Improved results with the addition of interferon alpha-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma. J Clin Oncol 1991; 9: 1403-8
    • (1991) J Clin Oncol , vol.9 , pp. 1403-1408
    • Falkson, C.1    Falkson, G.2    Falkson, H.3
  • 18
    • 0035136793 scopus 로고    scopus 로고
    • Single-agent dacarbazine versus combination chemotherapy with or without immunotherapy in metastatic melanoma: A meta-analysis of 3273 patients from 20 randomized trials
    • Huncharek M, Caubet JF, McGarry R. Single-agent dacarbazine versus combination chemotherapy with or without immunotherapy in metastatic melanoma: a meta-analysis of 3273 patients from 20 randomized trials. Melanoma Res 2001; 11: 75-81
    • (2001) Melanoma Res , vol.11 , pp. 75-81
    • Huncharek, M.1    Caubet, J.F.2    McGarry, R.3
  • 19
    • 0031718717 scopus 로고    scopus 로고
    • Results of interleukin-2 based treatment in advanced melanoma: A case record-based analysis of 631 patients
    • Keilholz U, Conradt C, Legha SS, et al. Results of interleukin-2 based treatment in advanced melanoma: a case record-based analysis of 631 patients. J Clin Oncol 1998; 16 (9): 2921-9
    • (1998) J Clin Oncol , vol.16 , Issue.9 , pp. 2921-2929
    • Keilholz, U.1    Conradt, C.2    Legha, S.S.3
  • 21
    • 17744421588 scopus 로고    scopus 로고
    • Multicentre phase III randomised trial of cisplatin, vindesine and dacarbazine (CVD) versus CVD plus subcutaneous (sc) interleukin-2 (IL-2) and interferon-alpha-2b (IFN) in metastatic melanoma patients (pts)
    • May 31-Jun 3; Chicago
    • Del Vecchio M, Bajetta E, Vitali M, et al. Multicentre phase III randomised trial of cisplatin, vindesine and dacarbazine (CVD) versus CVD plus subcutaneous (sc) interleukin-2 (IL-2) and interferon-alpha-2b (IFN) in metastatic melanoma patients (pts) [abstract no. 2849]. American Society of Clinical Oncology (ASCO) 39th Annual Meeting; 2003 May 31-Jun 3; Chicago
    • (2003) American Society of Clinical Oncology (ASCO) 39th Annual Meeting
    • Del Vecchio, M.1    Bajetta, E.2    Vitali, M.3
  • 22
    • 17844375261 scopus 로고    scopus 로고
    • Dacarbazine, cisplatin and IFN-alpha-2b with or without IL-2 in advanced melanoma: Final analysis of EORTC randomised phase III trial 18951
    • May 31-Jun 3; Chicago
    • Keilholz U, Punt CJ, Gore M, et al. Dacarbazine, cisplatin and IFN-alpha-2b with or without IL-2 in advanced melanoma: final analysis of EORTC randomised phase III trial 18951 [abstract no. 2848]. American Society of Clinical Oncology (ASCO) 39th Annual Meeting; 2003 May 31-Jun 3; Chicago
    • (2003) American Society of Clinical Oncology (ASCO) 39th Annual Meeting
    • Keilholz, U.1    Punt, C.J.2    Gore, M.3
  • 23
    • 1642275644 scopus 로고    scopus 로고
    • A prospective randomised phase III trial of concurrent biochemotherapy (BCT) with cisplatin, vinblastine, dacarbazine (CVD) IL-2 and interferon alpha-2b (IFN) versus CVD alone in patients with metastatic melanoma (E3695): An ECOG-coordinated intergroup trial
    • Atkins MB, Lee S, Flaherty LE, et al. A prospective randomised phase III trial of concurrent biochemotherapy (BCT) with cisplatin, vinblastine, dacarbazine (CVD) IL-2 and interferon alpha-2b (IFN) versus CVD alone in patients with metastatic melanoma (E3695): an ECOG-coordinated intergroup trial [abstract no. 2847]. Proc Am Soc Clin Oncol 2003; 22: 708
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 708
    • Atkins, M.B.1    Lee, S.2    Flaherty, L.E.3
  • 24
    • 0026513077 scopus 로고
    • Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
    • Newlands ES, Blackledge GR, Slack JA, et al. Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). Br J Cancer 1992; 65: 287-91
    • (1992) Br J Cancer , vol.65 , pp. 287-291
    • Newlands, E.S.1    Blackledge, G.R.2    Slack, J.A.3
  • 25
    • 0028944359 scopus 로고
    • Cancer Research Campaign phase II trial of temozolomide in malignant melanoma
    • Bleehan NM, Newlands ES, Lee SM, et al. Cancer Research Campaign phase II trial of temozolomide in malignant melanoma. J Clin Oncol 1995; 13: 910-3
    • (1995) J Clin Oncol , vol.13 , pp. 910-913
    • Bleehan, N.M.1    Newlands, E.S.2    Lee, S.M.3
  • 26
    • 0028174027 scopus 로고
    • Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide
    • Lee SM, Thatcher N, Crowther D, et al. Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide. Br J Cancer 1994; 69: 452-6
    • (1994) Br J Cancer , vol.69 , pp. 452-456
    • Lee, S.M.1    Thatcher, N.2    Crowther, D.3
  • 27
    • 1442283179 scopus 로고    scopus 로고
    • Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: A toxicity with therapeutic implications
    • Su YB, Sohn S, Krown SE, et al. Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications. J Clin Oncol 2004; 22 (3): 610-6
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 610-616
    • Su, Y.B.1    Sohn, S.2    Krown, S.E.3
  • 28
    • 0033897173 scopus 로고    scopus 로고
    • A phase II study of temozolomide vs procarbazine in glioblastoma multiforme at first relapse
    • Yung WK, Levin VA, Albright J, et al. A phase II study of temozolomide vs procarbazine in glioblastoma multiforme at first relapse. Br J Cancer 2000; 83: 588-93
    • (2000) Br J Cancer , vol.83 , pp. 588-593
    • Yung, W.K.1    Levin, V.A.2    Albright, J.3
  • 29
    • 3142588270 scopus 로고    scopus 로고
    • Concomitant and adjuvant temozolomide and whole brain irradiation on patients affected with brain metastases: A randomised multicentre phase II trial
    • Villa S, Verger E, Gil M, et al. Concomitant and adjuvant temozolomide and whole brain irradiation on patients affected with brain metastases: a randomised multicentre phase II trial. Int J Radiat Oncol 2003; 57 (2 Suppl.): S132
    • (2003) Int J Radiat Oncol , vol.57 , Issue.2 SUPPL.
    • Villa, S.1    Verger, E.2    Gil, M.3
  • 30
    • 33645440016 scopus 로고    scopus 로고
    • Concomitant and adjuvant temozolomide and radiotherapy for newly diagnosed glioblastoma multiforme: Conclusive results of a randomised phase III trial by the EORTC brain and RT groups and NCIC clinical trials group
    • Stupp R, Mason WP, Van Den Bent MJ, et al. Concomitant and adjuvant temozolomide and radiotherapy for newly diagnosed glioblastoma multiforme: conclusive results of a randomised phase III trial by the EORTC brain and RT groups and NCIC clinical trials group [abstract no. 2]. Proc Am Soc Clin Oncol 2004; 22 (145): 15
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 15
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 31
    • 0036246203 scopus 로고    scopus 로고
    • Effect of temozolomide on central nervous system relapse in patients with advanced melanoma
    • Paul MJ, Summers Y, Calvert H, et al. Effect of temozolomide on central nervous system relapse in patients with advanced melanoma. Melanoma Res 2002; 12 (2): 175-8
    • (2002) Melanoma Res , vol.12 , Issue.2 , pp. 175-178
    • Paul, M.J.1    Summers, Y.2    Calvert, H.3
  • 32
    • 2942689983 scopus 로고    scopus 로고
    • Temozolomide for the treatment of brain metastases associated with metastatic melanoma: A phase II study
    • Agarwala SS, Kirkwood JM, Gore M, et al. Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study. J Clin Oncol 2004; 22: 2101-7
    • (2004) J Clin Oncol , vol.22 , pp. 2101-2107
    • Agarwala, S.S.1    Kirkwood, J.M.2    Gore, M.3
  • 33
    • 0029066665 scopus 로고
    • Palliative therapy of melanoma patients with fotemustine. Inverse relationship between tumour load and effectiveness: A multi-centre phase II trial of the EORTC-melanoma cooperative group (MCG)
    • Kleeburg UR, Engel E, Israels P, et al. Palliative therapy of melanoma patients with fotemustine. Inverse relationship between tumour load and effectiveness: a multi-centre phase II trial of the EORTC-melanoma cooperative group (MCG). Melanoma Res 1995; 5: 195-200
    • (1995) Melanoma Res , vol.5 , pp. 195-200
    • Kleeburg, U.R.1    Engel, E.2    Israels, P.3
  • 34
    • 1842562211 scopus 로고    scopus 로고
    • Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: A phase III study
    • Avril MF, Aamdal S, Grob JJJ, et al. Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol 2004; 22: 1118-25
    • (2004) J Clin Oncol , vol.22 , pp. 1118-1125
    • Avril, M.F.1    Aamdal, S.2    Grob, J.J.J.3
  • 35
    • 0033623440 scopus 로고    scopus 로고
    • 6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of a phase II study
    • 6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study. Int J Cancer 2000; 88 (3): 469-73
    • (2000) Int J Cancer , vol.88 , Issue.3 , pp. 469-473
    • Middleton, M.R.1    Lee, S.M.2    Arance, A.3
  • 36
    • 0036023409 scopus 로고    scopus 로고
    • Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically respectable tumours
    • Dolan ME, Posner M, Karrison T, et al. Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically respectable tumours. Clin Cancer Res 2002; 8: 2519-23
    • (2002) Clin Cancer Res , vol.8 , pp. 2519-2523
    • Dolan, M.E.1    Posner, M.2    Karrison, T.3
  • 37
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumour activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • Tentori L, Leonetti C, Scarsella M, et al. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumour activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res 2003; 9: 5370-9
    • (2003) Clin Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 38
    • 0037478904 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
    • Hu Y, Cherton-Horvat G, Dragowska V, et al. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003; 9 (7): 2826-36
    • (2003) Clin Cancer Res , vol.9 , Issue.7 , pp. 2826-2836
    • Hu, Y.1    Cherton-Horvat, G.2    Dragowska, V.3
  • 39
    • 3142745263 scopus 로고    scopus 로고
    • Augmenting chemosensitivity of malignant melanoma tumours via proteasome inhibition: Implication for bortezomib (VEL-CADE, PS-341) as a therapeutic agent for malignant melanoma
    • Amiri KI, Horton LW, LaFleur BJ, et al. Augmenting chemosensitivity of malignant melanoma tumours via proteasome inhibition: implication for bortezomib (VEL-CADE, PS-341) as a therapeutic agent for malignant melanoma. Cancer Res 2004; 64: 4912-8
    • (2004) Cancer Res , vol.64 , pp. 4912-4918
    • Amiri, K.I.1    Horton, L.W.2    LaFleur, B.J.3
  • 40
    • 17844393765 scopus 로고    scopus 로고
    • Continuous low dose thalidomide: A phase II study in advanced melanoma, renal cell, ovarian and breast cancer
    • Eisen T, Boshoff C, Mak I, et al. Continuous low dose thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br J Cancer 2000; 14 (13 Suppl.): 17-20
    • (2000) Br J Cancer , vol.14 , Issue.13 SUPPL. , pp. 17-20
    • Eisen, T.1    Boshoff, C.2    Mak, I.3
  • 41
    • 0037676126 scopus 로고    scopus 로고
    • A randomised study of temozolomide (TMZ) alone, with interferon (TMZ-IFN) or with thalidomide (TMZ-THAL) in metastatic malignant melanoma (MMM)
    • Danson S, Lorigan P, Arance A, et al. A randomised study of temozolomide (TMZ) alone, with interferon (TMZ-IFN) or with thalidomide (TMZ-THAL) in metastatic malignant melanoma (MMM). J Clin Oncol 2003; 21 (13): 2551-7
    • (2003) J Clin Oncol , vol.21 , Issue.13 , pp. 2551-2557
    • Danson, S.1    Lorigan, P.2    Arance, A.3
  • 42
    • 0141688331 scopus 로고    scopus 로고
    • Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma
    • Hwu WJ, Krown SE, Menell JH, et al. Phase II study of temozolomide plus thalidomide for the treatment of metastatic melanoma. J Clin Oncol 2003; 21 (17): 3351-6
    • (2003) J Clin Oncol , vol.21 , Issue.17 , pp. 3351-3356
    • Hwu, W.J.1    Krown, S.E.2    Menell, J.H.3
  • 43
    • 0037021257 scopus 로고    scopus 로고
    • Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects
    • Dredge K, Marriott JB, Macdonald CD, et al. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects. Br J Cancer 2002; 87 (10): 1166-72
    • (2002) Br J Cancer , vol.87 , Issue.10 , pp. 1166-1172
    • Dredge, K.1    Marriott, J.B.2    Macdonald, C.D.3
  • 44
    • 11144355748 scopus 로고    scopus 로고
    • Phase I study to determine the safety, tolerability and immunostimulatory activity of the thalidomide analogue CC-5013 in patients with metastatic melanoma and other advanced cancers
    • Bartlett JB, Michael A, Clarke IA, et al. Phase I study to determine the safety, tolerability and immunostimulatory activity of the thalidomide analogue CC-5013 in patients with metastatic melanoma and other advanced cancers. Br J Cancer 2004; 90 (5): 955-61
    • (2004) Br J Cancer , vol.90 , Issue.5 , pp. 955-961
    • Bartlett, J.B.1    Michael, A.2    Clarke, I.A.3
  • 45
    • 0042165831 scopus 로고    scopus 로고
    • Alpha v integrin inhibitors and cancer therapy
    • Jun
    • Tucker GC. Alpha v integrin inhibitors and cancer therapy [erratum appears in Curr Opin Investig Drugs 2003; 4: 1140]. Curr Opin Investig Drugs. 2003 Jun; 4 (6): 722-31
    • (2003) Curr Opin Investig Drugs , vol.4 , Issue.6 , pp. 722-731
    • Tucker, G.C.1
  • 46
    • 17844366701 scopus 로고    scopus 로고
    • erratum appears
    • Tucker GC. Alpha v integrin inhibitors and cancer therapy [erratum appears in Curr Opin Investig Drugs 2003; 4: 1140]. Curr Opin Investig Drugs. 2003 Jun; 4 (6): 722-31
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 1140
  • 47
    • 17844374468 scopus 로고    scopus 로고
    • Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in patients with advanced melanoma
    • Peterson AC, Swiger S, Stadler W, et al. Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in patients with advanced melanoma [abstract no. 2863]. Proc Am Soc Clin Oncol 2003; 22: 712
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 712
    • Peterson, A.C.1    Swiger, S.2    Stadler, W.3
  • 48
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal carcinoma
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectal carcinoma. N Engl J Med 2004; 350 (23): 2335-42
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 49
    • 1642566596 scopus 로고    scopus 로고
    • A phase 2 trial of a recombinant humanised monoclonal anti-vascular endothelial growth factor (VEGF) antibody in patients with malignant melanoma
    • Carsons WE, Biber J, Shah N, et al. A phase 2 trial of a recombinant humanised monoclonal anti-vascular endothelial growth factor (VEGF) antibody in patients with malignant melanoma [abstract no. 2873]. Proc Am Soc Clin Oncol 2003; 22: 715
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 715
    • Carsons, W.E.1    Biber, J.2    Shah, N.3
  • 50
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 51
    • 1342268526 scopus 로고    scopus 로고
    • BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: The Italian Melanoma Intergroup Study
    • Casula M, Colombino M, Satta MP, et al. BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study. J Clin Oncol 2004; 22 (2): 286-92
    • (2004) J Clin Oncol , vol.22 , Issue.2 , pp. 286-292
    • Casula, M.1    Colombino, M.2    Satta, M.P.3
  • 52
    • 1542361349 scopus 로고    scopus 로고
    • Is there more than one road to melanoma?
    • Rivets JK. Is there more than one road to melanoma? Lancet 2004; 363: 728-30
    • (2004) Lancet , vol.363 , pp. 728-730
    • Rivets, J.K.1
  • 54
    • 0141508024 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with an orally available inhibitor of the ras-raf-MAPK cascade
    • Collisson EA, De A, Suzuki H, et al. Treatment of metastatic melanoma with an orally available inhibitor of the ras-raf-MAPK cascade. Cancer Res 2003; 63: 5669-73
    • (2003) Cancer Res , vol.63 , pp. 5669-5673
    • Collisson, E.A.1    De, A.2    Suzuki, H.3
  • 55
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumour activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumour progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumour activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumour progression and angiogenesis. Cancer Res 2004; 64: 7099-109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 56
    • 13144281830 scopus 로고    scopus 로고
    • BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience
    • Ahmad T, Marais R, Pyle L, et al. BAY 43-9006 in patients with advanced melanoma: the Royal Marsden experience [abstract no. 7506]. Proc Am Soc Clin Oncol 2004; 22 (145): 7115
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 7115
    • Ahmad, T.1    Marais, R.2    Pyle, L.3
  • 57
    • 16844376769 scopus 로고    scopus 로고
    • Phase I/II trial of BAY 43-9006, carboplatin and paclitaxel demonstrates preliminary antitumour activity in the expansion cohort patients with metastatic melanoma
    • Flaherty KT, Brose M, Schuchter L, et al. Phase I/II trial of BAY 43-9006, carboplatin and paclitaxel demonstrates preliminary antitumour activity in the expansion cohort patients with metastatic melanoma [abstract no. 7507]. Proc Am Soc Clin Oncol 2004; 22 (145): 7115
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 7115
    • Flaherty, K.T.1    Brose, M.2    Schuchter, L.3
  • 58
    • 0032986967 scopus 로고    scopus 로고
    • Differential expression of epidermal growth factor receptor melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization
    • Sparrow LE, Heenan PJ. Differential expression of epidermal growth factor receptor melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization. Australas J Dermatol 1999; 40 (1): 19-24
    • (1999) Australas J Dermatol , vol.40 , Issue.1 , pp. 19-24
    • Sparrow, L.E.1    Heenan, P.J.2
  • 59
    • 0141927463 scopus 로고    scopus 로고
    • Absence of HER2 overexpression in metastatic malignant melanoma
    • Inman JL, Kute T, White W. Absence of HER2 overexpression in metastatic malignant melanoma. J Surg Oncol 2003; 84 (2): 82-8
    • (2003) J Surg Oncol , vol.84 , Issue.2 , pp. 82-88
    • Inman, J.L.1    Kute, T.2    White, W.3
  • 60
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukaemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukaemia. N Engl J Med 2001; 344: 1031-7
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 61
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumours
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumours. N Engl J Med 2002; 347: 472-80
    • (2002) N Engl J Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 62
    • 17844388734 scopus 로고    scopus 로고
    • Expression of c-kit was found in more than 50% of early stages melanoma: A retrospective study of 261 patients
    • Janku F, Tomancova V, Novotny J, et al. Expression of c-kit was found in more than 50% of early stages melanoma: a retrospective study of 261 patients [abstract no. 2864]. Proc Am Soc Clin Oncol 2003; 22: 712
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 712
    • Janku, F.1    Tomancova, V.2    Novotny, J.3
  • 63
    • 4344615515 scopus 로고    scopus 로고
    • A phase II trial of imatinib mesylate at 800mg daily in metastatic melanoma: Lack of clinical efficacy with significant toxicity
    • Wyman K, Atkins MB, Hubbard F, et al. A phase II trial of imatinib mesylate at 800mg daily in metastatic melanoma: lack of clinical efficacy with significant toxicity [abstract no. 2865]. Proc Am Soc Clin Oncol 2003; 22: 713
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 713
    • Wyman, K.1    Atkins, M.B.2    Hubbard, F.3
  • 64
    • 10444262863 scopus 로고    scopus 로고
    • Available from URL
    • National Cancer Institute (NCI). Clinical trials [online]. Available from URL: www.cancer.gov/search/clinicaltrials [Accessed 2005 Feb 2]
    • Clinical Trials [Online]
  • 65
    • 0032739280 scopus 로고    scopus 로고
    • Histamine protects T cells and natural killer cells against oxidative stress
    • Hansson M, Hermodsson S, Brune M, et al. Histamine protects T cells and natural killer cells against oxidative stress. J Interferon Cytokine Res 1999; 19: 1135-44
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 1135-1144
    • Hansson, M.1    Hermodsson, S.2    Brune, M.3
  • 66
    • 0030027630 scopus 로고    scopus 로고
    • Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice
    • Asea A, Hermodsson S, Hellstrand K. Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice. Scand J Immunol 1996; 43: 9-15
    • (1996) Scand J Immunol , vol.43 , pp. 9-15
    • Asea, A.1    Hermodsson, S.2    Hellstrand, K.3
  • 67
    • 0027997609 scopus 로고
    • Histamine in immunotherapy of advanced melanoma: A pilot study
    • Hellstrand K, Naredi P, Lindner P, et al. Histamine in immunotherapy of advanced melanoma: a pilot study. Cancer Immunol Immunother 1994; 39: 416-9
    • (1994) Cancer Immunol Immunother , vol.39 , pp. 416-419
    • Hellstrand, K.1    Naredi, P.2    Lindner, P.3
  • 68
    • 17844395328 scopus 로고    scopus 로고
    • Maxim Pharmaceutical phase 3 trial for advanced melanoma fails to meet primary endpoint [media release]
    • Sep
    • Maxim Pharmaceuticals Press Conference. Maxim Pharmaceutical phase 3 trial for advanced melanoma fails to meet primary endpoint [media release]. 2004 Sep 20
    • (2004) Maxim Pharmaceuticals Press Conference , pp. 20
  • 69
    • 17844399413 scopus 로고    scopus 로고
    • First analysis of international M-02 trial: Histamine, interferon alpha-2b (IFN), interleukin (IL)-2 vs dacarbazine (DTIC)
    • Oct 10-11; Amsterdam
    • Hauschild A. First analysis of international M-02 trial: histamine, interferon alpha-2b (IFN), interleukin (IL)-2 vs dacarbazine (DTIC) [oral presentation]. European conference: Perspectives in Melanoma Management; 2003 Oct 10-11; Amsterdam
    • (2003) European Conference: Perspectives in Melanoma Management
    • Hauschild, A.1
  • 70
    • 1442339466 scopus 로고    scopus 로고
    • When will melanoma vaccines be proven effective?
    • Sosman JA, Weeraranta AT, Sondak VK. When will melanoma vaccines be proven effective? J Clin Oncol 2004; 22 (3): 387-9
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 387-389
    • Sosman, J.A.1    Weeraranta, A.T.2    Sondak, V.K.3
  • 71
    • 0028205790 scopus 로고
    • Improved survival in stage III melanoma patients with GM2 antibodies, a randomised trial of adjuvant vaccination with GM2 ganglioside
    • Livingstone PO, Wong GY, Adluri S, et al. Improved survival in stage III melanoma patients with GM2 antibodies, a randomised trial of adjuvant vaccination with GM2 ganglioside. J Clin Oncol 1994; 5: 1036-44
    • (1994) J Clin Oncol , vol.5 , pp. 1036-1044
    • Livingstone, P.O.1    Wong, G.Y.2    Adluri, S.3
  • 72
    • 0035339880 scopus 로고    scopus 로고
    • High dose interferon alpha 2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of inter-group trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA, et al. High dose interferon alpha 2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of inter-group trial E1694/S9512/C509801. J Clin Oncol 2001; 19 (9): 2370-80
    • (2001) J Clin Oncol , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 73
    • 0033579934 scopus 로고    scopus 로고
    • Tumour regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
    • Marchard M, von Baren N, Weynants P, et al. Tumour regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer 1999; 80: 219-30
    • (1999) Int J Cancer , vol.80 , pp. 219-230
    • Marchard, M.1    Von Baren, N.2    Weynants, P.3
  • 74
    • 17844367976 scopus 로고    scopus 로고
    • Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenze peptides in subjects with advanced malignant melanoma
    • Cebon J, Jager E, Shackleton MJ, et al. Two phase I studies of low dose recombinant human IL-12 with Melan-A and influenze peptides in subjects with advanced malignant melanoma. Cancer Immun 2003; 16: 3-7
    • (2003) Cancer Immun , vol.16 , pp. 3-7
    • Cebon, J.1    Jager, E.2    Shackleton, M.J.3
  • 75
    • 0031890206 scopus 로고    scopus 로고
    • Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
    • Rosenberg SA, Yang JC, Schwartzentruber DJ, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med 1998; 4: 321-7
    • (1998) Nat Med , vol.4 , pp. 321-327
    • Rosenberg, S.A.1    Yang, J.C.2    Schwartzentruber, D.J.3
  • 76
    • 17844405176 scopus 로고    scopus 로고
    • E1696: Final analysis of the clinical and immunological results of a multi-centre ECOG phase II trial of multi-epitope peptide vaccination for stage IV disease with MART-1, gp1000 and tyrosinase
    • Kirkwood J, Lee S, Land S, et al. E1696: final analysis of the clinical and immunological results of a multi-centre ECOG phase II trial of multi-epitope peptide vaccination for stage IV disease with MART-1, gp1000 and tyrosinase [abstract no. 7502]. Proc Am Soc Clin Oncol 2004; 22 (145): 7105
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 7105
    • Kirkwood, J.1    Lee, S.2    Land, S.3
  • 77
    • 3242658810 scopus 로고    scopus 로고
    • Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans
    • David I, Chen W, Jackson H, et al. Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans. Proc Natl Acad Sci U S A 2004; 101: 10697-702
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10697-10702
    • David, I.1    Chen, W.2    Jackson, H.3
  • 78
    • 0037089672 scopus 로고    scopus 로고
    • Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumour vaccine: Impact of HLA class I antigen expression on outcome
    • Southwest Oncology Group
    • Sosman JA, Unger JM, Liu PY, et al. Adjuvant immunotherapy of resected, intermediate-thickness, node-negative melanoma with an allogeneic tumour vaccine: impact of HLA class I antigen expression on outcome. Southwest Oncology Group. J Clin Oncol 2002; 20 (8): 2067-75
    • (2002) J Clin Oncol , vol.20 , Issue.8 , pp. 2067-2075
    • Sosman, J.A.1    Unger, J.M.2    Liu, P.Y.3
  • 79
    • 0018136615 scopus 로고
    • Preliminary results of a randomised trial of adjuvant immunotherapy in patients treated with malignant melanoma who have lymph node metastases
    • Morton DL, Eilber FR, Holmes EC, et al. Preliminary results of a randomised trial of adjuvant immunotherapy in patients treated with malignant melanoma who have lymph node metastases. Aust N Z J Surg 1978; 48: 49-52
    • (1978) Aust N Z J Surg , vol.48 , pp. 49-52
    • Morton, D.L.1    Eilber, F.R.2    Holmes, E.C.3
  • 80
    • 0031673815 scopus 로고    scopus 로고
    • Active immunotherapy with allogeneic tumour cell vaccines: Present status
    • Chan AD, Morton DL. Active immunotherapy with allogeneic tumour cell vaccines: present status. Semin Oncol 1998; 25: 611-22
    • (1998) Semin Oncol , vol.25 , pp. 611-622
    • Chan, A.D.1    Morton, D.L.2
  • 81
    • 0037108696 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: Clinical and immunologic findings
    • Belli F, Testori A, Rivoltini L, et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol 2002; 20 (20): 4169-80
    • (2002) J Clin Oncol , vol.20 , Issue.20 , pp. 4169-4180
    • Belli, F.1    Testori, A.2    Rivoltini, L.3
  • 82
    • 0141576738 scopus 로고    scopus 로고
    • Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    • Soiffer R, Hodi FS, Haluska F, et al. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J Clin Oncol 2003; 21 (17): 3343-50
    • (2003) J Clin Oncol , vol.21 , Issue.17 , pp. 3343-3350
    • Soiffer, R.1    Hodi, F.S.2    Haluska, F.3
  • 83
    • 17844405718 scopus 로고    scopus 로고
    • Results of a phase I study evaluating 'prime-boost' therapeutic vaccination strategies using a string of melanoma-derived CD8+ T cell epitopes in stage II/III/IV melanoma patients
    • Smith CL, Dunbar PR, Palmowski MJ, et al. Results of a phase I study evaluating 'prime-boost' therapeutic vaccination strategies using a string of melanoma-derived CD8+ T cell epitopes in stage II/III/IV melanoma patients [abstract no. 702]. Proc Am Soc Clin Oncol 2003; 22: 175
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 175
    • Smith, C.L.1    Dunbar, P.R.2    Palmowski, M.J.3
  • 84
    • 10344234206 scopus 로고    scopus 로고
    • Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence
    • Smith C, Dunbar P, Mirza F, et al. Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence. Int J Cancer 2005; 113 (2): 259-66
    • (2005) Int J Cancer , vol.113 , Issue.2 , pp. 259-266
    • Smith, C.1    Dunbar, P.2    Mirza, F.3
  • 85
    • 0034100896 scopus 로고    scopus 로고
    • Regression of human metastatic renal cell carcinoma after vaccination with tumour cell-dendritic cell hybrids
    • Kugler A, Stuhler G, Walden P, et al. Regression of human metastatic renal cell carcinoma after vaccination with tumour cell-dendritic cell hybrids. Nat Med 2000; 6: 332-6
    • (2000) Nat Med , vol.6 , pp. 332-336
    • Kugler, A.1    Stuhler, G.2    Walden, P.3
  • 86
    • 0142055970 scopus 로고    scopus 로고
    • Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8+ T-cell function in melanoma patients
    • Bedrosian I, Mick R, Xu S, et al. Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8+ T-cell function in melanoma patients. J Clin Oncol 2003; 21 (20): 3826-35
    • (2003) J Clin Oncol , vol.21 , Issue.20 , pp. 3826-3835
    • Bedrosian, I.1    Mick, R.2    Xu, S.3
  • 87
    • 17844401356 scopus 로고    scopus 로고
    • Dacarbazine versus vaccination with autologous peptide-pulsed dendritic cells as first-line treatment of patients with metastatic melanoma: Results of a prospective-randomised phase III study
    • Schadendorf D, Nestle FO, Broecker E-B, et al. Dacarbazine versus vaccination with autologous peptide-pulsed dendritic cells as first-line treatment of patients with metastatic melanoma: results of a prospective-randomised phase III study [abstract no. 7508]. Proc Am Soc Oncol 2004; 22 (145): 7125
    • (2004) Proc Am Soc Oncol , vol.22 , Issue.145 , pp. 7125
    • Schadendorf, D.1    Nestle, F.O.2    Broecker, E.-B.3
  • 88
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumour lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumour lymphocytes. Science 2002; 298: 850-4
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 89
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang J, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen4 blockade in patients with metastatic melanoma. Proc Nat Acad Sci U S A 2003; 100: 8372-7
    • (2003) Proc Nat Acad Sci U S A , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.2    Sherry, R.M.3
  • 90
    • 8344267742 scopus 로고    scopus 로고
    • A phase II randomised multi-centre study of MDX-010 alone or in combination with DTIC in stage IV malignant melanoma
    • Hersh E, Weber J, Powderly J, et al. A phase II randomised multi-centre study of MDX-010 alone or in combination with DTIC in stage IV malignant melanoma [abstract no. 7511]. Proc Am Soc Clin Oncol 2004; 22 (145): 7125
    • (2004) Proc Am Soc Clin Oncol , vol.22 , Issue.145 , pp. 7125
    • Hersh, E.1    Weber, J.2    Powderly, J.3
  • 91
    • 3242656979 scopus 로고    scopus 로고
    • CpG motifs are efficient adjuvants for DNA vaccines
    • Schneeder A, Wagner C, Zemann A, et al. CpG motifs are efficient adjuvants for DNA vaccines. J Invest Dermatol 2004; 123: 371-9
    • (2004) J Invest Dermatol , vol.123 , pp. 371-379
    • Schneeder, A.1    Wagner, C.2    Zemann, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.