Synthesis and antiviral activity of some C2-, C4-, and C6-substituted pyrazolo[3,4-d]pyrimidine acyclonucleosides with the alkylating chains of ACV, HBG, and iso-DHPG

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 8, 2006, Pages 849-860

  Moukha Chafiq, Omar ^a,e   Taha, Mohamed ^a   Lazrek, Hassan ^b   Vasseur, Jean Jacques ^c   Clercq, Erik ^d  

^a FACULTÉ DES SCIENCES   (Morocco)

^b FACULTÉ DES SCIENCES SEMLALIA   (Morocco)

^c UNIV MONTPELLIER   (France)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Acyclonucleoside; Analogues of ACV, HBG, and iso DHPG; C2 , C4 , and C6 substituted pyrazolo 3,4 d pyrimidines

Indexed keywords

1 (2 HYDROXYETHOXY)METHYL 3 METHYL 4,6 DIMETHYLTHIO 1H PYRAZOLO[3,4 D]PYRIMIDINE; 1 (2,3 DIHYDROXY 1 PROPOXY)METHYL 3 METHYL 4,6 DIMETHYLTHIO 1H PYRAZOLO[3,4 D]PYRIMIDINE; 1 (4 HYDROXYBUTYL) 3 METHYL 4,6 DIMETHYLTHIO 1H PYRAZOLO[3,4 D]PYRIMIDINE; 3 BROMO 1 (2 HYDROXYETHOXY)METHYL 4,6 DIMETHYLTHIO 1H PYRAZOLO [3,4 D]PYRIMIDINE; 3 BROMO 1 (2,3 DIHYDROXY 1 PROPOXY)METHYL 4,6 DIMETHYLTHIO 1H PYRAZOLO[3,4 D]PYRIMIDINE; 3 BROMO 1 (4 HYDROXYBUTYL) 4,6 DIMETHYLTHIO 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 1 (2 HYDROXYETHOXY)METHYL 3 METHYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 1 (2,3 DIHYDROXY 1 PROPOXY)METHYL 3 METHYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 1 (4 HYDROXYBUTYL) 3 METHYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 3 BROMO 1 (2 HYDROXYETHOXY)METHYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 3 BROMO 1 (2,3 DIHYDROXY 1 PROPOXY)METHYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4,6 DIBENZYLTHIO 3 BROMO 1 (4 HYDROXYBUTYL) 1H PYRAZOLO[3,4 D]PYRIMIDINE; 9 (HYDROXYBUTYL)GUANINE; ACICLOVIR; ACYCLIC NUCLEOSIDE; ALKYLATING AGENT; GLYCOL; GUANINE DERIVATIVE; ISODIHYDROXYPHENYL GLYCOL; NUCLEOSIDE; PYRAZOLO[3,4 D]PYRIMIDINE ACYLNUCLEOSIDE; UNCLASSIFIED DRUG; VIRUS DNA;

ALKYLATION; ARTICLE; SUBSTITUTION REACTION; VIRUS CULTURE; VIRUS REPLICATION;

ACYCLOVIR; ANTIVIRAL AGENTS; CELLS, CULTURED; HUMANS; PYRAZOLES; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES; SESQUITERPENES; VIRUS REPLICATION;

DNA VIRUSES;

EID: 33746823349     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600793802     Document Type: Article

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