The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 7, 2008, Pages 1284-1291

  Kip, Miriam Julia ^a   Spies, Claudia Doris ^a   Neumann, Tim ^a   Nachbar, Yvonne ^a   Alling, Christer ^b   Aradottir, Steina ^b   Weinmann, Wolfgang ^c   Friedrich Martin Wurst, ^d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF FREIBURG   (Germany)

^d PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Alcohol Use Disorders; Direct Ethanol Metabolites; Emergency Room; Internal Medicine; Self Reports; Traditional Biological State Markers

Indexed keywords

ALCOHOL DERIVATIVE; BIOLOGICAL MARKER; CARBOHYDRATE DEFICIENT TRANSFERRIN; ETHYL GLUCURONIDE; GAMMA GLUTAMYLTRANSFERASE; PHOSPHATIDYLETHANOL; UNCLASSIFIED DRUG; CARBOHYDRATE-DEFICIENT TRANSFERRIN; DRUG DERIVATIVE; GLUCURONIC ACID; GLYCEROPHOSPHOLIPID; TRANSFERRIN;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL USE DISORDER; ALCOHOL USE DISORDER IDENTIFICATION TEST; ALCOHOLISM; ARTICLE; BLOOD SAMPLING; CLINICAL ASSESSMENT; EMERGENCY WARD; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; SCORING SYSTEM; SELF REPORT; THORAX PAIN; URINALYSIS; BLOOD; EMERGENCY HEALTH SERVICE; MASS SCREENING; MEAN CORPUSCULAR VOLUME; METABOLISM; MIDDLE AGED; PROSPECTIVE STUDY; QUESTIONNAIRE; URINE;

ADULT; ALCOHOL-RELATED DISORDERS; BIOLOGICAL MARKERS; EMERGENCY SERVICE, HOSPITAL; ERYTHROCYTE INDICES; GAMMA-GLUTAMYLTRANSFERASE; GLUCURONATES; GLYCEROPHOSPHOLIPIDS; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; PROSPECTIVE STUDIES; QUESTIONNAIRES; TRANSFERRIN;

EID: 54749135863     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00696.x     Document Type: Article

References (43)

1. Allen JP, Litten RZ, Strid N, Sillanaukee P (2001) The role of biomarkers in alcoholism medication trials. Alcohol Clin Exp Res 25:1119-1125.
2. Alling C, Gustavsson L, Anggard E (1983) An abnormal phospholipid in rat organs after ethanol treatment. FEBS Lett 152:24-28.
3. Alt A, Janda I, Seidl S, Wurst FM (2000) Determination of ethyl glucuronide in hair samples. Alcohol Alcohol 35:313-314.
4. Aradottir S, Asanovska G, Gjerss S, Hansson P, Alling C (2006) Phosphatidy-lethanol (PEth) concentrations in blood are correlated to reported alcohol intake in alcohol-dependent patients. Alcohol Alcohol 41:431-437.
5. Aradottir S, Olsson BL (2005) Methodological modifications on quantification of phosphatidylethanol in blood from humans abusing alcohol, using high-performance liquid chromatography and evaporative light scattering detection. BMC Biochem 6:18.
6. Babor T, Higgins-Biddle JC, Saunders JB, Monteiro M (2001) The Alcohol Use Disorder Identification Test - Guidelines for Use in Primary Care. World Health Organization - Department of Mental Health and Substance Dependence, WHO/MSD/MSB/01.6a.
7. Borucki K, Schreiner R, Dierkes J, Jachau K, Krause D, Westphal S, Wurst FM, Luley C, Schmidt-Gayk H (2005) Detection of recent ethanol intake with new markers: comparison of fatty acid ethyl esters in serum and of ethyl glucuronide and the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid in urine. Alcohol Clin Exp Res 29:781-787.
8. Breuer JP, Neumann T, Heinz A, Kox WJ, Spies C (2003) The alcoholic patient in the daily routine. Wien Klin Wochenschr 115:618-633.
9. Conigrave KM, Degenhardt LJ, Whitfield JB, Saunders JB, Helander A, Tabakoff B (2002) CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Alcohol Clin Exp Res 26:332-339.
10. Dahl H, Stephanson N, Beck O, Helander A (2002) Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J Anal Toxicol 26:201-204.
11. Gunnarsson T, Karlsson A, Hansson P, Johnson G, Alling C, Odham G (1998) Determination of phosphatidylethanol in blood from alcoholic males using high-performance liquid chromatography and evaporative light scattering or electrospray mass spectrometric detection. J Chromatogr B Bio-med Sci Appl 705:243-249.
12. Hartmann S, Aradottir S, Graf M, Wiesbeck G, Lesch O, Ramskogler K, Wolfersdorf M, Alling C, Wurst FM (2007) Phosphatidylethanol as a sensitive and specific biomarker: comparison with gamma-glutamyl transpepti-dase, mean corpuscular volume and carbohydrate-deficient transferrin. Addict Biol 12:81-84.
13. Helander A (2003) Biological markers in alcoholism. J Neural Transm Suppl 66:15-32.
14. Kypri K, McGee R, Saunders JB, Langley JD, Dean JI (2002) Interpretation of items in the AUDIT questionnaire. Alcohol Alcohol 37:465-467.
15. Laposata M (1999) Assessment of ethanol intake. Current tests and new assays on the horizon. Am J Clin Pathol 112:443-450.
16. Malyutina S, Bobak M, Kurilovitch S, Gafarov V, Simonova G, Nikitin Y, Marmot M (2002) Relation between heavy and binge drinking and all-cause and cardiovascular mortality in Novosibirsk, Russia: a prospective cohort study. Lancet 360:1448-1454.
17. Martin MJ, Heymann C, Neumann T, Schmidt L, Soost F, Mazurek B, Bohm B, Marks C, Helling K, Lenzenhuber E, Muller C, Kox WJ, Spies CD (2002) Preoperative evaluation of chronic alcoholics assessed for surgery of the upper digestive tract. Alcohol Clin Exp Res 26:836-840.
18. Moore RD, Bone LR, Geller G, Mamon JA, Stokes EJ, Levine DM (1989) Prevalence, detection, and treatment of alcoholism in hospitalized patients. JAMA 261:403-407.
19. Moss M, Burnham EL (2006) Alcohol abuse in the critically ill patient. Lancet 368:2231-2242.
20. Neumann T, Neuner B, Gentilello LM, Weiss-Gerlach E, Mentz H, Rettig JS, Schroder T, Wauer H, Muller C, Schutz M, Mann K, Siebert G, Dettling M, Muller JM, Kox WJ, Spies CD (2004) Gender differences in the performance of a computerized version of the alcohol use disorders identification test in subcritically injured patients who are admitted to the emergency department. Alcohol Clin Exp Res 28:1693-1701.
21. Neumann T, Spies C (2003) Use of biomarkers for alcohol use disorders in clinical practice. Addiction 98(Suppl 2):81-91.
22. Sander M, Neumann T, von DV, Schonfeld H, Lau A, Eggers V, Spies CD (2006) Alcohol use disorder: risks in anesthesia and intensive care medicine. Internist (Berl) 47:332-341.
23. Saunders JB, Aasland OG, Babor TF, de lF Jr, Grant M (1993) Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Con-sumption-II. Addiction 88:791-804.
24. Schellenberg F, Schwan R, Mennetrey L, Loiseaux MN, Pages JC, Reynaud M (2005) Dose-effect relation between daily ethanol intake in the range 0-70 grams and %CDT value: validation of a cut-off value. Alcohol Alcohol 40:531-534.
25. Schmitt G, Aderjan R, Keller T, Wu M (1995) Ethyl glucuronide: an unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. J Anal Toxicol 19:91-94.
26. Skipper GE, Weinmann W, Thierauf A, Schaefer P, Wiesbeck G, Allen JP, Miller M, Wurst FM (2004) Ethyl glucuronide: a biomarker to identify alcohol use by health professionals recovering from substance use disorders. Alcohol Alcohol 39:445-449.
27. Spies CD, Neumann T, Otter H, Kox WJ (2003) Klinische Relevanz der Such-terkrankungen in operativen Kliniken. Suchtmedizin in Forschung und Praxis 5:7-12.
28. Spies CD, Neuner B, Neumann T, Blum S, Muller C, Rommelspacher H, Rieger A, Sanft C, Specht M, Hannemann L, Striebel HW, Schaf-fartzik W (1996a) Intercurrent complications in chronic alcoholic men admitted to the intensive care unit following trauma. Intensive Care Med 22:286-293.
29. Spies CD, Nordmann A, Brummer G, Marks C, Conrad C, Berger G, Runkel N, Neumann T, Muller C, Rommelspacher H, Specht M, Hannemann L, Striebel HW, Schaffartzik W (1996b) Intensive care unit stay is prolonged in chronic alcoholic men following tumor resection of the upper digestive tract. Acta Anaesthesiol Scand 40:649-656.
30. Spies CD, Sander M, Stangl K, Fernandez-Sola J, Preedy VR, Rubin E, Andreasson S, Hanna EZ, Kox WJ (2001b) Effects of alcohol on the heart. Curr Opin Crit Care 7:337-343.
31. Spies C, Tonnesen H, Andreasson S, Helander A, Conigrave K (2001a) Peri-operative morbidity and mortality in chronic alcoholic patients. Alcohol Clin Exp Res, 25 (5 Suppl ISBRA):164S-170S.
32. Spies CD, von Dossow V, Eggers V, Jetschmann G, El Hilali R, Egert J, Fischer M, Schroder T, Hoflich C, Sinha P, Paschen C, Mirsalim P, Brunsch R, Hopf J, Marks C, Wernecke KD, Pragst F, Ehrenreich H, Muller C, Tonnesen H, Oelkers W, Rohde W, Stein C, Kox WJ (2004) Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients. Anesthesiology 100:1088-1100.
33. Stockwell T, Donath S, Cooper-Stanbury M, Chikritzhs T, Catalano P, Mateo C (2004) Under-reporting of alcohol consumption in household surveys: a comparison of quantity-frequency, graduated-frequency and recent recall. Addiction 99:1024-1033.
34. Thomas VS, Rockwood KJ (2001) Alcohol abuse, cognitive impairment, and mortality among older people. J Am Geriatr Soc 49:415-420.
35. Tonnesen H, Kehlet H (1999) Preoperative alcoholism and postoperative morbidity. Br J Surg 86:869-874.
36. Varga A, Hansson P, Lundqvist C, Alling C (1998) Phosphatidylethanol in blood as a marker of ethanol consumption in healthy volunteers: comparison with other markers. Alcohol Clin Exp Res 22:1832-1837.
37. Weinmann W, Schaefer P, Thierauf A, Schreiber A, Wurst FM (2004) Confirmatory analysis of ethylglucuronide in urine by liquid-chromatogra-phy/ electrospray ionization/tandem mass spectrometry according to forensic guidelines. J Am Soc Mass Spectrom 15:188-193.
38. Wurst FM, Alexson S, Wolfersdorf M, Bechtel G, Forster S, Alling C, Aradottir S, Jachau K, Huber P, Allen JP, Auwarter V, Pragst F (2004a) Concentration of fatty acid ethyl esters in hair of alcoholics: comparison to other biological state markers and self reported-ethanol intake. Alcohol Alcohol 39:33-38.
39. Wurst FM, Kempter C, Seidl S, Alt A (1999a) Ethyl glucuronide-a marker of alcohol consumption and a relapse marker with clinical and forensic implications. Alcohol Alcohol 34:71-77.
40. Wurst FM, Metzger J (2002) The ethanol conjugate ethyl glucuronide is a useful marker of recent alcohol consumption. Alcohol Clin Exp Res 26:1114-1119.
41. Wurst FM, Schuttler R, Kempter C, Seidl S, Gilg T, Jachau K, Alt A (1999b) Can ethyl glucuronide be determined in post-mortem body fluids and tissues? Alcohol Alcohol 34:262-263.
42. Wurst FM, Skipper GE, Weinmann W (2003) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98(Suppl2):51-61.
43. Wurst FM, Wiesbeck GA, Metzger JW, Weinmann W (2004b) On sensitivity, specificity, and the influence of various parameters on ethyl glucuronide levels in urine-results from the WHO/ISBRA study. Alcohol Clin Exp Res 28:1220-1228.