Studies on the toxicity of gambogic acid in rats

Journal of Ethnopharmacology

Volumn 117, Issue 3, 2008, Pages 433-438

  Qi, Qi ^a   You, Qidong ^a   Gu, Hongyan ^a   Zhao, Li ^a   Liu, Wei ^a   Lu, Na ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anticancer agents; Anticancer plants; Gambogic acid; Garcinia hanbury; Guttiferae; Toxicity

Indexed keywords

ANTINEOPLASTIC AGENT; GAMBOGIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SURFACE; CHEMICAL ANALYSIS; CONTROLLED STUDY; FEMALE; GARCINIA; HISTOPATHOLOGY; KIDNEY INJURY; LIVER INJURY; MALE; NONHUMAN; RAT; SOUTHEAST ASIA;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BEHAVIOR, ANIMAL; BLOOD CELL COUNT; BODY WEIGHT; FEMALE; GARCINIA; KIDNEY; LIVER; LIVER FUNCTION TESTS; MALE; MYOCARDIUM; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; XANTHONES;

ANIMALIA; CLUSIACEAE; GARCINIA; GARCINIA HANBURYI; RATTUS;

EID: 42749092824     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.02.027     Document Type: Article

References (23)

1. Abd-Elhamid H.F. Investigation of induced biochemical and histopathological parameters of acetonitril extract of Jatropha carcus in albino rats. Journal of the Egyptian Society of Parasitology 34 (2004) 397-406
2. Akdogan M., Kilinc I., Oncu M., Karaoz E., and Delibas N. Investigation of biochemical and histopathological effects of Mentha piperita L. and Mentha spicata L. on kidney tissue in rats. Human and Experimental Toxicology 22 (2003) 213-219
3. Asano J., Chiba K., Tada M., and Yoshii T. Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry 41 (1996) 815-820
4. Auterhoff H., Frauendorf H., Liesenklas W., and Schwandt C. The chief constituents of gamboge resins. 1. Chemistry of gamboges. Archiv Der Pharmazie 295 (1962) 833-846
5. Fujii T. Toxicological correlation between changes in blood biochemical parameters and liver histopathological findings. Journal of Toxicological Science 22 (1997) 161-183
6. Geroni C., Ripamonti M., Arrigoni C., Fiorentini F., Capolongo L., Moneta D., Marchini S., Della Torre P., Albanese C., Lamparelli M.G., Ciomei M., Rossi R., and Caruso M. Pharmacological and toxicological aspects of 4-demethoxy-3′-deamino-3′-aziridinyl-4′-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent. Cancer Research 61 (2001) 1983-1990
7. Guo Q.L., Lin S.S., You Q.D., Gu H.Y., Yu J., Zhao L., Qi Q., Liang F., Tan Z., and Wang X. Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. Life Sciences 78 (2006) 1238-1245
8. Jun Y., Guo Q.L., You Q.D., Zhao L., Gu H.Y., Yang Y., Zhang H.W., Tan Z., and Wang X. Gambogic acid induced G2/M phase cell cycle arrest via disturbing CDK7 mediated phosphorylation of CDC2/P34 in human gastric carcinoma BGC-823 cells. Carcinogenesis (2006)
9. Kajihara M., Okazaki Y., Kato S., Ishii H., Kawakami Y., Ikeda Y., and Kuwana M. Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura. Journal of Gastroenterology and Hepatology 22 (2007) 112-118
10. Kasibhatla S., Jessen K.A., Maliartchouk S., Wang J.Y., English N.M., Drewe J., Qiu L., Archer S.P., Ponce A.E., Sirisoma N., Jiang S., Zhang H.Z., Gehlsen K.R., Cai S.X., Green D.R., and Tseng B. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 12095-12100
11. Kouitcheu Mabeku L.B., Penlap Beng V., Kouam J., Essame O., and Etoa F.X. Toxicological evaluation of ethyl acetate extract of Cylicodiscus gabunensis stem bark (Mimosaceae). Journal of Ethnopharmacology 111 (2007) 598-606
12. Lott J.A. Practical problems in clinical enzymology. CRC Critical Reviews in Clinical Laboratory Sciences 8 (1977) 277-301
13. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193 (1951) 265-275
14. Nascimbene A., Iannacone M., Brando B., and De Gasperi A. Acute thrombocytopenia after liver transplant: role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment. Journal of Hepatology 47 (2007) 651-657
15. Natelson S., Scott M.L., and Beffa C. A rapid method for the estimation of urea in biologic fluids. American Journal of Clinical Pathology 21 (1951) 275-281
16. Parekh A.C., Caranto M., Mathur R.K., and Jung D.H. Fractionation of serum cholesterol: a critique. Annals of Clinical and Laboratory Sciences 6 (1976) 423-429
17. Singh S.S. Preclinical pharmacokinetics: an approach towards safer and efficacious drugs. Current Drug Metabolism 7 (2006) 165-182
18. Theocharis S.E., Kanelli H., Margeli A.P., Spiliopoulou C.A., and Koutselinis A.S. Metallothionein and heat shock protein expression during acute liver injury and regeneration in rats. Clinical Chemistry and Laboratory Medicine 38 (2000) 1137-1140
19. Tofovic S.P., and Jackson E.K. Effects of long-term caffeine consumption on renal function in spontaneously hypertensive heart failure prone rats. Journal of Cardiovascular Pharmacology 33 (1999) 360-366
20. Vasilescu C., Nereantiu F., and Carp N. IV. Histopathological investigation of acute poisoning in dogs. Bul Stiint Sect Stiint Medicale Acad Republicii Pop Romane 7 (1955) 571-572
21. Wu Z.Q., Guo Q.L., You Q.D., Zhao L., and Gu H.Y. Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biological and Pharmaceutical Bulletin 27 (2004) 1769-1774
22. Yu J., Guo Q.L., You Q.D., Lin S.S., Li Z., Gu H.Y., Zhang H.W., Tan Z., and Wang X. Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. Cancer Chemotherapy and Pharmacology 58 (2006) 434-443
23. Zhao L., Guo Q.L., You Q.D., Wu Z.Q., and Gu H.Y. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. Biological and Pharmaceutical Bulletin 27 (2004) 998-1003