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Volumn 44, Issue 3, 2009, Pages 258-263

Progress in the research on multi-target-directed drugs against Alzheimer's disease

Author keywords

Alzheimer's disease; Multi target directed; Selective estrogen receptor modulators

Indexed keywords

SELECTIVE ESTROGEN RECEPTOR MODULATOR;

EID: 67249156779     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (41)
  • 1
    • 50949166667 scopus 로고    scopus 로고
    • Mixed results for disease-modification strategies for Alzheimer's disease [J]
    • Opar A. Mixed results for disease-modification strategies for Alzheimer's disease [J]. Nat Rev Drug Discov, 2008, 7: 717-718.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 717-718
    • Opar, A.1
  • 2
    • 34247876141 scopus 로고    scopus 로고
    • Therapies for Alzheimer's disease [J]
    • Melnikova I. Therapies for Alzheimer's disease [J]. Nat Rev Drug Discov, 2007, 6: 34 1-342.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.34 , pp. 1-342
    • Melnikova, I.1
  • 3
    • 26944477318 scopus 로고    scopus 로고
    • Multiple weak hits confuse complex systems: A transcriptional regulatory network as an example [J]
    • Agoston V, Csermely P, Pongor S. Multiple weak hits confuse complex systems: A transcriptional regulatory network as an example [J], Phys Rev E Stat Nonlin Soft Matter Phys, 2005,71(5 Pt 1): 051909.
    • (2005) Phys Rev E Stat Nonlin Soft Matter Phys , vol.71 , Issue.5 PART 1 , pp. 051909
    • Agoston, V.1    Csermely, P.2    Pongor, S.3
  • 4
    • 3242743000 scopus 로고    scopus 로고
    • Strong links are important, but weak links stabilize them [J]
    • Csermely P. Strong links are important, but weak links stabilize them [J]. Trends Biochem Sci, 2004, 29: 33 1-334.
    • (2004) Trends Biochem Sci , vol.29 , Issue.33 , pp. 1-334
    • Csermely, P.1
  • 5
    • 0029869159 scopus 로고    scopus 로고
    • Fink DM, Palermo MG, Bores GM, et al. Imino 1, 2, 3, 4- tetrahydrocyclopent [b] indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase [J]. Bioorg Med Chem Lett, 1996, 6: 625-630.
    • Fink DM, Palermo MG, Bores GM, et al. Imino 1, 2, 3, 4- tetrahydrocyclopent [b] indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase [J]. Bioorg Med Chem Lett, 1996, 6: 625-630.
  • 6
    • 0037153195 scopus 로고    scopus 로고
    • Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer' s disease [J]
    • Sterling J, Herzig Y, Goren T, et al. Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer' s disease [J]. J Med Chem, 2002, 45: 5260-5279.
    • (2002) J Med Chem , vol.45 , pp. 5260-5279
    • Sterling, J.1    Herzig, Y.2    Goren, T.3
  • 7
    • 33644531884 scopus 로고    scopus 로고
    • Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages [J]
    • Ronchetti D, Impagnatiello F, Guzzetta M, et al. Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages [J]. Eur J Pharmacol, 2006, 532: 162-169.
    • (2006) Eur J Pharmacol , vol.532 , pp. 162-169
    • Ronchetti, D.1    Impagnatiello, F.2    Guzzetta, M.3
  • 8
    • 31544477481 scopus 로고    scopus 로고
    • Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties [J]
    • Rodriguez-franco MI, Fernandez-bachiller MI, Perez C, et al. Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties [J]. J Med Chem, 2006, 49: 459-462.
    • (2006) J Med Chem , vol.49 , pp. 459-462
    • Rodriguez-franco, M.I.1    Fernandez-bachiller, M.I.2    Perez, C.3
  • 9
    • 40449084828 scopus 로고    scopus 로고
    • M1 muscarinic agonists target major hallmarks of Alzheimer' s disease - the pivotal role of brain Ml receptors [J]
    • Fisher A. M1 muscarinic agonists target major hallmarks of Alzheimer' s disease - the pivotal role of brain Ml receptors [J]. Neurodegener Dis, 2008, 5: 237-240.
    • (2008) Neurodegener Dis , vol.5 , pp. 237-240
    • Fisher, A.1
  • 10
    • 2442465965 scopus 로고    scopus 로고
    • Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration [J]
    • Li L, Sengupta A, Haque N, et al. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration [J]. FEBS Lea, 2004, 566: 261-269.
    • (2004) FEBS Lea , vol.566 , pp. 261-269
    • Li, L.1    Sengupta, A.2    Haque, N.3
  • 11
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer' s disease: A randomised, double-blind, placebo-controlled study [J]
    • Doody RS, Gavrilova SI, Sano M, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer' s disease: A randomised, double-blind, placebo-controlled study [J]. Lancet, 2008, 372: 207-215.
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3
  • 12
    • 12344328416 scopus 로고    scopus 로고
    • Rational approach to discover multipotent anti-Alzheimer drugs [J]
    • Rosini M, Andrisano V, Bartolini M, et al. Rational approach to discover multipotent anti-Alzheimer drugs [J]. J Med Chem, 2005,48: 360-363.
    • (2005) J Med Chem , vol.48 , pp. 360-363
    • Rosini, M.1    Andrisano, V.2    Bartolini, M.3
  • 13
    • 11144316146 scopus 로고    scopus 로고
    • Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases [J]
    • Youdim MBH, Fridkin M, Zheng HL. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases [J]. Mech Ageing Dev, 2005, 126: 317-326.
    • (2005) Mech Ageing Dev , vol.126 , pp. 317-326
    • Youdim, M.B.H.1    Fridkin, M.2    Zheng, H.L.3
  • 14
    • 20044370990 scopus 로고    scopus 로고
    • Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces arnyloid in vivo [J]
    • Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces arnyloid in vivo [J]. J Biol Chem, 2005, 280: 5892-590l.
    • (2005) J Biol Chem , vol.280
    • Yang, F.1    Lim, G.P.2    Begum, A.N.3
  • 15
    • 33750943629 scopus 로고    scopus 로고
    • Neuroprotective effects of huperzine A: New therapeutic targets fomeurodegenerative disease [J]
    • Zhang HY, Tang XC. Neuroprotective effects of huperzine A: New therapeutic targets fomeurodegenerative disease [J]. Trends Pharmacol Sci, 2006, 27: 619-625.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 619-625
    • Zhang, H.Y.1    Tang, X.C.2
  • 17
    • 25144511407 scopus 로고    scopus 로고
    • Investigative models for determining hormone therapy-induced outcomes in brain: Evidence in support of a healthy cell bias of estrogen action [J]
    • Brinton RD. Investigative models for determining hormone therapy-induced outcomes in brain: Evidence in support of a healthy cell bias of estrogen action [J]. Ann N Y Acad Sci, 2005, 1052: 57-74.
    • (2005) Ann N Y Acad Sci , vol.1052 , pp. 57-74
    • Brinton, R.D.1
  • 18
    • 34247150317 scopus 로고    scopus 로고
    • Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications [J]
    • Brann DW, Dhandapani K, Walcade C, et al. Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications [J]. Steroids, 2007, 72: 381-405.
    • (2007) Steroids , vol.72 , pp. 381-405
    • Brann, D.W.1    Dhandapani, K.2    Walcade, C.3
  • 19
    • 0030843969 scopus 로고    scopus 로고
    • Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer [J]
    • Collaborative Group on Hormonal Factors in Breast Cancer
    • Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer [J]. Lancet, 1997, 350: 1047-1059.
    • (1997) Lancet , vol.350 , pp. 1047-1059
  • 20
    • 0031058448 scopus 로고    scopus 로고
    • Beresford SA, Weiss NS, Voigt LF, Ct al. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women [J]. Lancet, 1997, 349: 458-461.
    • Beresford SA, Weiss NS, Voigt LF, Ct al. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women [J]. Lancet, 1997, 349: 458-461.
  • 21
    • 0026874818 scopus 로고
    • Compliance with hormone replacement therapy: Are women receiving the full impact of hormone replacement therapy preventive heath benefits? [J]
    • Ravnikar VA. Compliance with hormone replacement therapy: Are women receiving the full impact of hormone replacement therapy preventive heath benefits? [J]. Women Health Issues, 1992, 2: 75-80.
    • (1992) Women Health Issues , vol.2 , pp. 75-80
    • Ravnikar, V.A.1
  • 22
    • 13444311864 scopus 로고    scopus 로고
    • Brinton RD. Requirements of a brain selective estrogen: Advances and remaining challenges for developing a NeuroSERM [J]. JAlzheimers Dis, 2004,6: S27-35.
    • Brinton RD. Requirements of a brain selective estrogen: Advances and remaining challenges for developing a NeuroSERM [J]. JAlzheimers Dis, 2004,6: S27-35.
  • 23
    • 3042751870 scopus 로고    scopus 로고
    • Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease [J]
    • O'Neill K, Chen SH, Bnnton RD. Impact of the selective estrogen receptor modulator, tamoxifen, on neuronal outgrowth and survival following toxic insults associated with aging and Alzheimer's disease [J]. Exp Neurol, 2004, 188: 268-278.
    • (2004) Exp Neurol , vol.188 , pp. 268-278
    • O'Neill, K.1    Chen, S.H.2    Bnnton, R.D.3
  • 24
    • 0347624528 scopus 로고    scopus 로고
    • Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheirner's disease [J]
    • O'Neill K, Chen SH, Brinton RD. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheirner's disease [J]. Exp Neurol, 2004, 185: 63-80.
    • (2004) Exp Neurol , vol.185 , pp. 63-80
    • O'Neill, K.1    Chen, S.H.2    Brinton, R.D.3
  • 25
    • 33751160616 scopus 로고    scopus 로고
    • Estrogenic agonist activity of ICI 182780 (Faslodex) in hippocampal neurons: Implications for basic science under-standing of estrogen signaling and development of estrogen modulators with a dual therapeutic profile [J]
    • Zhao LQ, O'Neill K, Brinton RD. Estrogenic agonist activity of ICI 182780 (Faslodex) in hippocampal neurons: Implications for basic science under-standing of estrogen signaling and development of estrogen modulators with a dual therapeutic profile [J]. J Pharmacol Exp Ther, 2006, 319: 1124-1132.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1124-1132
    • Zhao, L.Q.1    O'Neill, K.2    Brinton, R.D.3
  • 26
    • 0035912147 scopus 로고    scopus 로고
    • Yaffe KK, Krueger 5, Sarkar D, et al. Cognitive function in postmenopausal women treated with raloxifene [J]. N Engl J Med, 2001, 344: 1207-1213.
    • Yaffe KK, Krueger 5, Sarkar D, et al. Cognitive function in postmenopausal women treated with raloxifene [J]. N Engl J Med, 2001, 344: 1207-1213.
  • 27
    • 40749104202 scopus 로고    scopus 로고
    • Estrogen receptor beta in the brain: From form to function [J]
    • Weiser Mi, Foradori CD, Handa RJ. Estrogen receptor beta in the brain: From form to function [J]. Brain Res Rev, 2008, 57: 309-320.
    • (2008) Brain Res Rev , vol.57 , pp. 309-320
    • Mi, W.1    Foradori, C.D.2    Handa, R.J.3
  • 28
    • 67249084998 scopus 로고    scopus 로고
    • The study of the relationship between hippocampal ERs gene expression and brain degeneration and learning and memory function [D]
    • An SJ. The study of the relationship between hippocampal ERs gene expression and brain degeneration and learning and memory function [D]. Beijing: Academy of Military Medical Science, 2002.
    • (2002) Beijing: Academy of Military Medical Science
    • An, S.J.1
  • 29
    • 0033876197 scopus 로고    scopus 로고
    • Estrogen receptor beta is coexpressed with ERa and PR and associated with nodal status, grade, and proliferation rate in breast cancer [J]
    • Jarvinen TA, Pelto-Huildco M, Hoffi K, et al. Estrogen receptor beta is coexpressed with ERa and PR and associated with nodal status, grade, and proliferation rate in breast cancer [J]. Am J Pathol, 2000, 156: 29-35.
    • (2000) Am J Pathol , vol.156 , pp. 29-35
    • Jarvinen, T.A.1    Pelto-Huildco, M.2    Hoffi, K.3
  • 30
    • 42449163010 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice [J]
    • Carroll JC, Pike CJ. Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice [J]. Endocrinology, 2008, 149: 2607-2611.
    • (2008) Endocrinology , vol.149 , pp. 2607-2611
    • Carroll, J.C.1    Pike, C.J.2
  • 31
    • 33646473146 scopus 로고    scopus 로고
    • Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta [J]
    • Escande A, Pillon A, Balaguer P. et al. Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta [J]. Biochem Pharmacol, 2006, 71: 1459-1469.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1459-1469
    • Escande, A.1    Pillon, A.2    Balaguer, P.3
  • 32
    • 0036655701 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons [J]
    • Zhao LX, Chen Q, Brinton RD. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons [J]. Exp Biol Med, 2002, 227: 509-519.
    • (2002) Exp Biol Med , vol.227 , pp. 509-519
    • Zhao, L.X.1    Chen, Q.2    Brinton, R.D.3
  • 33
    • 2342635931 scopus 로고    scopus 로고
    • Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity [J]
    • Bang OY, Hong HS, Kim DH, et al. Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity [J]. Neurobiol Dis, 2004, 16: 21-28.
    • (2004) Neurobiol Dis , vol.16 , pp. 21-28
    • Bang, O.Y.1    Hong, H.S.2    Kim, D.H.3
  • 34
    • 0034303760 scopus 로고    scopus 로고
    • Establishment and its application of a reportor-based screening model for discovering new ligands of estrogen receptor α subtypes [J]
    • Japanese Source
    • Sun Z, Lu QJ, Wen LQ, et al. Establishment and its application of a reportor-based screening model for discovering new ligands of estrogen receptor α subtypes [J]. Acta Pharm Sin (Japanese Source)2000, 35: 747-751.
    • (2000) Acta Pharm Sin , vol.35 , pp. 747-751
    • Sun, Z.1    Lu, Q.J.2    Wen, L.Q.3
  • 35
    • 33750175387 scopus 로고    scopus 로고
    • Establishment of a reportor gene-based cell screening model for discovering new agonists of estrogen receptor β subtype [J]
    • Chen LM, Lu QJ, Wen LQ, et al. Establishment of a reportor gene-based cell screening model for discovering new agonists of estrogen receptor β subtype [J]. Ada Phana Sin (Japanese Source) 2006,41: 721-726.
    • (2006) Ada Phana Sin (Japanese Source) , vol.41 , pp. 721-726
    • Chen, L.M.1    Lu, Q.J.2    Wen, L.Q.3
  • 36
    • 67249154694 scopus 로고    scopus 로고
    • Tu PH. Pu XP, Shang WF, et al. New pharmaceutical usage of echinacoside (Japanese Source): CN, 200510002898 [P]. 2006-08-02.
    • Tu PH. Pu XP, Shang WF, et al. New pharmaceutical usage of echinacoside (Japanese Source): CN, 200510002898 [P]. 2006-08-02.
  • 37
    • 67049105460 scopus 로고    scopus 로고
    • Neuroprotective effects of liquiritin and its inhibitory actions on cholinesterase acitivity [J]
    • Japanese Source
    • Liu RT, Bian GX, Zou LB, et al. Neuroprotective effects of liquiritin and its inhibitory actions on cholinesterase acitivity [J]. Chin New Drugs J (Japanese Source)2008, 17: 41-44.
    • (2008) Chin New Drugs J , vol.17 , pp. 41-44
    • Liu, R.T.1    Bian, G.X.2    Zou, L.B.3
  • 38
    • 47349133541 scopus 로고    scopus 로고
    • Neuroprotection and neurotrophism effects of liquiritin on primary cultured hippocampal cells [J]
    • Japanese Source
    • Yang Y, Bian GX, Lu QJ. Neuroprotection and neurotrophism effects of liquiritin on primary cultured hippocampal cells [J]. ChinaJ Chin Mater Med (Japanese Source)2008, 33: 931-935.
    • (2008) ChinaJ Chin Mater Med , vol.33 , pp. 931-935
    • Yang, Y.1    Bian, G.X.2    Lu, Q.J.3
  • 39
    • 39149111920 scopus 로고    scopus 로고
    • Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist [J]
    • Mersereau JE, Levy N, Staub RE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist [J]. Mol Ccl Endocrinol, 2008, 283: 49-57.
    • (2008) Mol Ccl Endocrinol , vol.283 , pp. 49-57
    • Mersereau, J.E.1    Levy, N.2    Staub, R.E.3
  • 40
    • 42949164997 scopus 로고    scopus 로고
    • ΚB- dependent iNOS and proinflammatory cytokines production [J]
    • ΚB- dependent iNOS and proinflammatory cytokines production [J]. Br J Pharinacol, 2008, 154: 165-173.
    • (2008) Br J Pharinacol , vol.154 , pp. 165-173
    • Kim, Y.W.1    Thao, R.J.2    Park, S.J.3
  • 41
    • 84954358351 scopus 로고    scopus 로고
    • Neurodegenerative disease: New ways of tackling Aβ toxicity [J]
    • Flight MH. Neurodegenerative disease: new ways of tackling Aβ toxicity [J]. Nat Rev Drug Discov, 2008, 7: 889.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 889
    • Flight, M.H.1


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