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1
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Alanis MC, Lucidi RS: Neonatal circumcision: a review of the world's oldest and most controversial operation. Obstet. Gynecol. Surv. 59(5), 379-395 (2004).
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Potential HIV-1 target cells in the human penis
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Describes the thinner keratin layer and greater proximity of Langerhans' cells to the epithelial surface in the inner foreskin tissue as compared with other penile tissues
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McCoombe SG, Short RV: Potential HIV-1 target cells in the human penis. AIDS 20, 1491-1495 (2006). • Describes the thinner keratin layer and greater proximity of Langerhans' cells to the epithelial surface in the inner foreskin tissue as compared with other penile tissues.
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Nyagaya, E.A.6
MacLean, I.7
Bailey, R.C.8
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4
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0036733682
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Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture
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Describes the greater proportion of HIV-1 target cells and greater ex vivo susceptibility to HIV-1 infection in foreskin mucosa as compared with cervical mucosa or the external surface of the foreskin
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Patterson BK, Landay A, Siegel JN et al.: Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am. J. Pathol. 161(3), 867-873 (2002). • Describes the greater proportion of HIV-1 target cells and greater ex vivo susceptibility to HIV-1 infection in foreskin mucosa as compared with cervical mucosa or the external surface of the foreskin.
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Am. J. Pathol.
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Patterson, B.K.1
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In this meta-analysis of observational data, risk of syphilis and chancroid infection was lower in circumcised men for. Herpes simplex virus type-2 risk was lower, but with borderline statistical significance
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Weiss HA, Thomas SL, Munabi SK, Hayes RJ: Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. Sex. Transm. Infect. 82(2), 101-109 (2006). • In this meta-analysis of observational data, risk of syphilis and chancroid infection was lower in circumcised men for. Herpes simplex virus type-2 risk was lower, but with borderline statistical significance.
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Halperin DT, Bailey RC: Male circumcision and HIV infection: 10 years and counting. Lancet 354 (9192), 1813-1815 (1999).
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Male circumcision and risk of HIV infection in sub-Saharan Africa: A systematic review and meta-analysis
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In this meta-analysis of observational data on male circumcision (MC) and HIV-1 infection risk in sub-Saharan Africa, HIV-1 risk was significantly lower in circumcised men, particularly those at high risk for HIV infection
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Weiss HA, Quigley MA, Hayes RJ: Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS 14(15), 2361-2370 (2000). • In this meta-analysis of observational data on male circumcision (MC) and HIV-1 infection risk in sub-Saharan Africa, HIV-1 risk was significantly lower in circumcised men, particularly those at high risk for HIV infection.
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Weiss, H.A.1
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CD003362 This systematic review of observational studies found an epidemiological association between male circumcision and prevention of HIV, especially among high-risk groups
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Siegfried N, Muller M, Volmink J et al.: Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst. Rev. 3, CD003362 (2003). • This systematic review of observational studies found an epidemiological association between male circumcision and prevention of HIV, especially among high-risk groups.
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Gray RH, Kiwanuka N, Quinn TC et al.: Male circumcision and HIV acquisition and transmission: cohort studies in Rakai, Uganda. Rakai Project Team. AIDS 14(15), 2371-2381 (2000). (Pubitemid 30832108)
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Mangen, F.W.6
Lutalo, T.7
Nalugoda, F.8
Kelly, R.9
Meehan, M.10
Chen, M.Z.11
Li, C.12
Wawer, M.J.13
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13
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28444460441
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Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 Trial
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First of the three randomized, controlled clinical trials to be concluded. With 3274 men aged 18-24 years in South Africa randomized to immediate versus delayed MC, they found a 60% reduction in HIV infection risk
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Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A: randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med. 2(11), E298 (2005). •• First of the three randomized, controlled clinical trials to be concluded. With 3274 men aged 18-24 years in South Africa randomized to immediate versus delayed MC, they found a 60% reduction in HIV infection risk.
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PLoS Med.
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Auvert, B.1
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14
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Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomized controlled trial
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This randomized, controlled clinical trial in Kenya included 2784 men aged 18-24 years and found a 53% reduction in HIV infection risk in men randomized to MC
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Bailey RC, Moses S, Parker CB et al.: Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomized controlled trial. Lancet 369, 643-656 (2007). • This randomized, controlled clinical trial in Kenya included 2784 men aged 18-24 years and found a 53% reduction in HIV infection risk in men randomized to MC.
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This randomized, controlled clinical trial in Uganda included 4996 men aged 18-49 years and found a 51% reduction in HIV infection risk in men randomized to MC. The investigators also studied transmission from HIV-infected men to their partners in a related study
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Gray RH, Kigozi G, Serwadda D et al.: Male circumcision for HIV prevention in men in Rakai, Uganda: a randomized trial. Lancet 369, 657-666 (2007). •• This randomized, controlled clinical trial in Uganda included 4996 men aged 18-49 years and found a 51% reduction in HIV infection risk in men randomized to MC. The investigators also studied transmission from HIV-infected men to their partners in a related study.
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The protective effect of male circumcision is sustained for at least 42 months: Results from the Kisumu, Kenya Trial
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Presented at
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Bailey RC, Moses S, Parker CB et al.: The protective effect of male circumcision is sustained for at least 42 months: results from the Kisumu, Kenya Trial. Presented at: XVIII International AIDS Conference. Mexico City, Mexico, 3-8 August 2008.
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XVIII International AIDS Conference. Mexico City, Mexico, 3-8 August 2008
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Mattson CL, Campbell RT, Bailey RC, Agot K, Ndinya-Achola JO, Moses S: Risk compensation is not associated with male circumcision in Kisumu, Kenya: a multifaceted assessment of men enrolled in a randomized controlled trial. PLoS ONE 3(6), E2443 (2008).
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Krieger JN, Mehta SD, Bailey RC et al.: Adult male circumcision: effects on sexual function and sexual satisfaction in Kisumu, Kenya. J. Sex. Med. 5(11), 2610-2622 (2008).
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Kigozi G, Watya S, Polis CB et al.: The effect of male circumcision on sexual satisfaction and function, results from a randomized trial of male circumcision for human immunodeficiency virus prevention, Rakai, Uganda. Brit. J. Urol. 101(1), 65-70 (2008). (Pubitemid 350233575)
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Bacon, M.C.10
Ssempijja, V.11
Makumbi, F.12
Gray, R.H.13
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20
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58749101526
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Male circumcision and risk of HIV infection among heterosexual African-American men attending Baltimore sexually transmitted disease clinics
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Among 394 visits by African-American men with known HIV exposure to Baltimore sexually transmitted disease clinics, MC was associated with a 51% lower HIV infection prevalence
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Warner L, Ghanem KG, Newman DR, Macaluso M, Sullivan PS, Erbelding EJ: Male circumcision and risk of HIV infection among heterosexual African-American men attending Baltimore sexually transmitted disease clinics. J. Infect. Dis. 199(1), 59-65 (2009). • Among 394 visits by African-American men with known HIV exposure to Baltimore sexually transmitted disease clinics, MC was associated with a 51% lower HIV infection prevalence.
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Wawer M, Kigozi G, Serwadda D et al.: Trial of male circumcision in HIV+ men, Rakai, Uganda: effects in HIV+ men and in women partners. Presented at: 15th Conference on Retroviruses and Opportunistic Infections. Boston, MA, USA, 3-6 February 2008.
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Lutalo, T.7
Nalugoda, F.8
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Gray RH, Kigozi G, Serwadda D et al.: The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. Am. J. Obstet. Gynecol. 200(1), E1-E42 (2009).
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Varghese B, Maher JE, Peterman TA, Branson BM, Steketee RW: Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex. Transm. Dis. 29, 38-43 (2002). (Pubitemid 34074430)
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Seropositive Urban Men's Study Team
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erratum 301(11), 1126-1129 (2009). In this meta-analysis of 15 studies, overall, HIV infection risk was not decreased in circumcised men who have sex with men
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Millett GA, Flores SA, Marks G, Reed JB, Herbst JH: Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: a meta-analysis. JAMA 300(14), 1674-1684 (2008); erratum 301(11), 1126-1129 (2009). • In this meta-analysis of 15 studies, overall, HIV infection risk was not decreased in circumcised men who have sex with men.
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Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners
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In this study, MC was associated with a reduced risk of penile human papillomavirus infection and, in the case of men with a history of multiple sexual partners, a reduced risk of cervical cancer in their female partners
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Castellsagué X, Bosch FX, Muñoz N et al.: Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N. Engl. J. Med. 346(15), 1105-1112 (2002). • In this study, MC was associated with a reduced risk of penile human papillomavirus infection and, in the case of men with a history of multiple sexual partners, a reduced risk of cervical cancer in their female partners.
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Sobngwi-Tambekou J, Taljaard D, Nieuwoudt M, Lissouba P, Puren A, Auvert B: Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis: observations in the aftermath of a randomised controlled trial for HIV prevention. Sex. Transm. Infect. 85(2), 116-120 (2009) (Epub ahead of print).
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Effect of male circumcision on the prevalence of high-risk human papillomavirus in young men: Results of a randomized controlled trial conducted in Orange Farm, South Africa
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