Male circumcision for the prevention of HSV-2 and HPV infections and syphilis

New England Journal of Medicine

Volumn 360, Issue 13, 2009, Pages 1298-1309

  Tobian, Aaron A R ^a   Serwadda, David ^f,g   Quinn, Thomas C ^b,i,j   Kigozi, Godfrey ^h   Gravitt, Patti E ^c   Laeyendecker, Oliver ^b,i   Charvat, Blake ^d   Ssempijja, Victor ^h   Riedesel, Melissa ⁱ   Oliver, Amy E ^b   Nowak, Rebecca G ^c   Moulton, Lawrence H ^e   Chen, Michael Z ^d   Reynolds, Steven J ^b,i   Wawer, Maria J ^d   Gray, Ronald H ^d  

^a Departments of Pathology   (Uganda)

^b Medicine   (Uganda)

^c Department of Epidemiology and Molecular Microbiology Immunology   (Uganda)

^d Population Family and Reproductive Health   (Uganda)

^e International Health and Biostatistics   (Uganda)

^f JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^g MAKERERE UNIVERSITY   (Uganda)

^h RAKAI HEALTH SCIENCES PROGRAM   (Uganda)

ⁱ NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^j Rangos Building ^*  (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CIRCUMCISION; CLINICAL TRIAL; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RISK; INTERVIEW; MALE; NORMAL HUMAN; PHYSICAL EXAMINATION; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SEROCONVERSION; SEXUALLY TRANSMITTED DISEASE; SYPHILIS; VERRUCA VULGARIS; VIRUS INFECTION; WART VIRUS; WESTERN BLOTTING; CONDOM; EPIDEMIOLOGY; GENETICS; GENITAL HERPES; INCIDENCE; ISOLATION AND PURIFICATION; KAPLAN MEIER METHOD; PAPILLOMA VIRUS; SEXUAL BEHAVIOR; TREPONEMA PALLIDUM; UTILIZATION REVIEW;

ADOLESCENT; ADULT; CIRCUMCISION, MALE; CONDOMS; CONFOUNDING FACTORS (EPIDEMIOLOGY); GENOTYPE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; HUMANS; INCIDENCE; KAPLAN-MEIERS ESTIMATE; MALE; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PREVALENCE; SEXUAL BEHAVIOR; SYPHILIS; TREPONEMA PALLIDUM; YOUNG ADULT;

EID: 63249101515     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa0802556     Document Type: Article

References (40)

1. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet 2001;357: 1513-8.
2. Corey L, Wald A, Celum CL, Quinn TC. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr 2004;35:435-45.
3. Fenton KA, Breban R, Vardavas R, et al. Infectious syphilis in high-income settings in the 21st century. Lancet Infect Dis 2008;8:244-53.
4. Serwadda D, Gray RH, Sewankambo NK, et al. Human immunodeficiency virus acquisition associated with genital ulcer disease and herpes simplex virus type 2 infection: a nested case-control study in Rakai, Uganda. J Infect Dis 2003;188: 1492-7.
5. de Sanjose S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical human papilloma-virus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis 2007;7:453-9.
6. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518
7. Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial.Lancet 2007;369:657-66.
8. Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet 2007;369:643-56.
9. Auvert B, Taljaard D, Lagarde E, Sobngwi-Tambekou J, Sitta R, Puren A. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med 2005;2(11):e298. [Erratum, PLoS Med 2006;3(5):e298.]
10. Auvert B, Buve A, Lagarde E, et al. Male circumcision and HIV infection in four cities in sub-Saharan Africa. AIDS 2001;15:Suppl 4:S31-S40.
11. Weiss HA, Buve A, Robinson NJ, et al. The epidemiology of HSV-2 infection and its association with HIV infection in four urban African populations. AIDS 2001;15: Suppl 4:S97-S108.
12. Xu F, Markowitz LE, Sternberg MR, Aral SO. Prevalence of circumcision and herpes simplex virus type 2 infection in men in the United States: the National Health and Nutrition Examination Survey(NHANES), 1999-2004. Sex Transm Dis 2007;34:479-84.
13. Lavreys L, Rakwar JP, Thompson ML, et al. Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: a prospective cohort study of trucking company employees in Kenya. J Infect Dis 1999;180:330-6.
14. Reynolds SJ, Shepherd ME, Risbud AR, et al. Male circumcision and risk of HIV-1 and other sexually transmitted infections in India. Lancet 2004;363:1039-40.
15. Gray R, Azire J, Serwadda D, et al. Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda. AIDS 2004;18:2428-30.
16. Bwayo J, Plummer F, Omari M, et al. Human immunodeficiency virus infection in long-distance truck drivers in east Africa. Arch Intern Med 1994;154:1391-6.
17. Cook LS, Koutsky LA, Holmes KK. Circumcision and sexually transmitted diseases. Am J Public Health 1994;84:197-201.
18. Urassa M, Todd J, Boerma JT, Hayes R, Isingo R. Male circumcision and susceptibility to HIV infection among men in Tanzania. AIDS 1997;11:73-80.
19. Weiss HA, Thomas SL, Munabi SK, Hayes RJ. Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. Sex Transm Infect 2006;82:101-9.
20. Baldwin SB, Wallace DR, Papenfuss MR, et al. Human papillomavirus infec-tion in men attending a sexually transmitted disease clinic. J Infect Dis 2003;187: 1064-70.
21. Castellsague X, Bosch FX, Munoz N, et al. Male circumcision, penile human papillomavirus infection, and cervical can cer in female partners. N Engl J Med 2002;346:1105-12.
22. Shin HR, Franceschi S, Vaccarella S, et al. Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea. J Infect Dis 2004;190:468-76.
23. Weaver BA, Feng Q, Holmes KK, et al. Evaluation of genital sites and sampling techniques for detection of human papil-lomavirus DNA in men. J Infect Dis 2004;189:677-85.
24. Wawer M, Kigozi G, Serwadda D, et al. Trial of male circumcision in HIV+ men, Rakai, Uganda: effects in HIV+ men and in women partners. In: Proceedings of the 15th Conference on Retroviruses and Opportunistic Infections, Boston, February 3-6, 2008. abstract.
25. Gamiel JL, Tobian AAR, Laeyendecker OB, et al. Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda. Clin Vaccine Immunol 2008;15: 888-90.
26. Gravitt PE, Peyton CL, Alessi TQ, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol 2000; 38:357-61.
27. Gravitt PE, Peyton CL, Apple RJ, Wheeler CM. Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 1998;36:3020-7.
28. Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 1995;87:796-802.
29. Cogliano V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F. Carcinogenic-ity of human papillomaviruses. Lancet Oncol 2005;6:204.
30. Sobngwi-Tambekou J, Taljaard D, Lis-souba P, et al. Effect of HSV-2 serostatus on acquisition of HIV by young men: results of a longitudinal study in Orange Farm, South Africa. J Infect Dis 2009;199(in press).
31. Auvert B, Sobngwi-Tambekou J, Cutler E, et al. Effect of male circumcision on the prevalence of high-risk human papilloma-virus in young men: results of a randomized controlled trial conducted in Orange Farm, South Africa. J Infect Dis 2009;199:14-9.
32. Szabo R, Short RV. How does male circumcision protect against HIV infection? BMJ 2000;320:1592-4.
33. McCoombe SG, Short RV. Potential HIV-1 target cells in the human penis. AIDS 2006;20:1491-5.
34. Gupta R, Warren T, Wald A. Genital herpes. Lancet 2007;370:2127-37.
35. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001;357:1149-53.
36. Corey L, Adams HG, Brown ZA, Holmes KK. Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med 1983; 98:958-72.
37. Corey L, Handsfield HH. Genital herpes and public health: addressing a global problem. JAMA 2000;283:791-4.
38. Celum C, Wald A, Hughes J, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial. Lancet 2008;371:2109-19.
39. Watson-Jones D, Weiss HA, Rusizoka M, et al. Effect of herpes simplex suppression on incidence of HIV among women in Tanzania. N Engl J Med 2008;358:1560-71.
40. Gray RH, Kigozi G, Serwadda D, et al. The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda. Am J Obstet Gynecol 2009;200(1):42.e1-42.e7.