HIV-1 target cells in foreskin of African men with varying histories of sexually transmitted infections

American Journal of Clinical Pathology

Volumn 125, Issue 3, 2006, Pages 386-391

  Donoval, Betty A ^a   Landay, Alan L ^b   Moses, Stephen ^c   Agot, Kawango ^d   Ndinya Achola, J O ^e   Nyagaya, Edith A ^d   MacLean, Ian ^c   Bailey, Robert C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b RUSH UNIVERSITY   (United States)

^c UNIVERSITY OF MANITOBA   (Canada)

^d UNIM Project   (Kenya)

^e UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

Circumcision; Foreskin; HIV 1; Immunohistochemistry

Indexed keywords

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL DENSITY; CIRCUMCISION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION SENSITIVITY; KENYA; LANGERHANS CELL; MACROPHAGE; MALE; PREPUCE; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; TARGET CELL;

EID: 33644647926     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/JVHQVDJDYKM58EPH     Document Type: Article

References (19)

1. Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO). AIDS Epidemic Update, December 2004. Geneva, Switzerland: UNAIDS; 2004.
2. Caldwell JC, Caldwell P. The African AIDS epidemic. Sci Am. 1996;274:62-63, 66-68.
3. Auvert B, Buve A, Ferry B, et al, for the Akam Study Group on the Heterogeneity of HIV Epidemics in African Cities. Ecological and individual level analysis of risk factors for HIV infection in four urban populations in sub-Saharan Africa with different levels of HIV infection. AIDS. 2001;suppl 4:S15-S30.
4. Moses S, Bradley JE, Nagelkerke NJ, et al. Geographical patterns of male circumcision practices in Africa: association with HIV seroprevalence. Int J Epidemiol. 1990;19:693-697.
5. Bongaarts J, Reining P, Way P, et al. The relationship between male circumcision and HIV infection in African populations. AIDS. 1989;6:373-377.
6. Szabo R, Short RV. How does male circumcision protect against HIV infection? BMJ. 2000;320:1592-1594.
7. Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis. AIDS. 2000;14:2361-2370.
8. O'Farrell N, Egger M. Circumcision in men and the prevention of HIV infection: a "meta-analysis" revisited. Int J STD AIDS. 2000;11:137-142.
9. Bailey RC, Plummer FA, Moses S. Male circumcision and HIV prevention: current knowledge and future research directions. Lancet Infect Dis. 2001;1:223-231.
10. Siegfried N, Muller M, Volmink J, et al. Male circumcision for the prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev. 2003, Issue 3. Available at http://www.mrw.interscience.wiley.com/cochrane/ clsysrev/artic les/CD003362/frame.html. Accessed March 2004.
11. Patterson BK, Landay A, Siegel JN, et al. Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. Am J Pathol. 2002;161:867-873.
12. Soilleux EJ, Coleman N. Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV [letter]. J Clin Pathol. 2004;57:77-78.
13. Hussain LA, Lehner T. Comparative investigation of Langerhans' cells and potential receptors for HIV in oral, genitourinary and rectal epithelia. Immunology. 1995;85:475-484.
14. McCoombe SC, Short RV. How HIV enters the human penis. Poster presented at: XV International AIDS Conference; July 11-16, 2004; Bangkok, Thailand. MoPeA3048.
15. Goldsby RA, Kindt TJ, Osborne BA. Appendix: CD antigens. Kuby Immunology. 4th ed. New York, NY: WH Freeman; 2000:593-607.
16. Flemming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999;75:3-17.
17. Bentwich Z, Maartens G, Torten D, et al. Concurrent infections and HIV pathogenesis. AIDS. 2000;14:2071-2081.
18. King R, Gough J, Ronald A, et al. An immunohistochemical analysis of naturally occurring chancroid. J Infect Dis. 1996;174:427-430.
19. Levine WC, Pope V, Bhoomkar A, et al. Increase in endocervical CD4 lymphocytes among women with nonulcerative sexually transmitted diseases. J Infect Dis. 1998;177:167-174.