-
1
-
-
16844364980
-
-
Geurts JJ, Bo L, Pouwels PJ, et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am J Neuro-radiol 2005; 26:572-577.
-
Geurts JJ, Bo L, Pouwels PJ, et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am J Neuro-radiol 2005; 26:572-577.
-
-
-
-
2
-
-
33748997359
-
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
-
Wegner C, Esiri MM, Chance SA, et al. Neocortical neuronal, synaptic, and glial loss in multiple sclerosis. Neurology 2006; 67:960-967.
-
(2006)
Neurology
, vol.67
, pp. 960-967
-
-
Wegner, C.1
Esiri, M.M.2
Chance, S.A.3
-
3
-
-
42749087378
-
Diffuse cortical atrophy in a marmoset model of multiple sclerosis
-
Reinforcing previous work by Wegner et al, 2, this study suggests that atrophy in the cortex is not confined to demyelinated regions, and that cortical atrophy is, therefore, not solely the local consequence of demyelination
-
Pomeroy IM, Jordan EK, Frank JA, et al. Diffuse cortical atrophy in a marmoset model of multiple sclerosis. Neurosci Lett 2008; 437:121-124. Reinforcing previous work by Wegner et al. [2], this study suggests that atrophy in the cortex is not confined to demyelinated regions, and that cortical atrophy is, therefore, not solely the local consequence of demyelination.
-
(2008)
Neurosci Lett
, vol.437
, pp. 121-124
-
-
Pomeroy, I.M.1
Jordan, E.K.2
Frank, J.A.3
-
4
-
-
0032764919
-
Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: Evidence for distinct mechanisms of lesion genesis?
-
Lee MA, Smith S, Palace J, et al. Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis? Brain 1999; 122 (Pt 7):1261-1270.
-
(1999)
Brain
, vol.122
, Issue.PART 7
, pp. 1261-1270
-
-
Lee, M.A.1
Smith, S.2
Palace, J.3
-
5
-
-
60249099507
-
Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: A comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord
-
This study shows that all grey matter regions are not equal, and that the burden of pathology may vary considerably between them
-
Gilmore CP, Donaldson I, Bo L, et al. Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. J Neural Neurosurg Psychiatry 2009; 80:182-187. This study shows that all grey matter regions are not equal, and that the burden of pathology may vary considerably between them.
-
(2009)
J Neural Neurosurg Psychiatry
, vol.80
, pp. 182-187
-
-
Gilmore, C.P.1
Donaldson, I.2
Bo, L.3
-
6
-
-
33646829924
-
Cortical demyelination in multiple sclerosis: A substrate for cognitive deficits?
-
Kutzelnigg A, Lassmann H. Cortical demyelination in multiple sclerosis: a substrate for cognitive deficits? J Neural Sci 2006; 245:123-126.
-
(2006)
J Neural Sci
, vol.245
, pp. 123-126
-
-
Kutzelnigg, A.1
Lassmann, H.2
-
7
-
-
58149122959
-
The complex genetics of multiple sclerosis: Pitfalls and prospects
-
Sawcer S. The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 2008; 131 (Pt 12):3118-3131.
-
(2008)
Brain
, vol.131
, Issue.PART 12
, pp. 3118-3131
-
-
Sawcer, S.1
-
8
-
-
34248680532
-
-
*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis. Int Rev Neurobiol 2007; 79:521-535. This work (along with the work by Enzinger et al. [9]) demonstrates that genetic factors not only influence the risk of a person developing MS, they also influence the severity of pathology.
-
*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis. Int Rev Neurobiol 2007; 79:521-535. This work (along with the work by Enzinger et al. [9]) demonstrates that genetic factors not only influence the risk of a person developing MS, they also influence the severity of pathology.
-
-
-
-
9
-
-
1642366079
-
Accelerated evolution of brain atrophy and 'black holes' in MS patients with APOE-epsilon 4
-
Enzinger C, Ropele S, Smith S, et al. Accelerated evolution of brain atrophy and 'black holes' in MS patients with APOE-epsilon 4. Ann Neural 2004; 55:563-569.
-
(2004)
Ann Neural
, vol.55
, pp. 563-569
-
-
Enzinger, C.1
Ropele, S.2
Smith, S.3
-
10
-
-
0032576752
-
Axonal transection in the lesions of multiple sclerosis
-
Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338:278-285.
-
(1998)
N Engl J Med
, vol.338
, pp. 278-285
-
-
Trapp, B.D.1
Peterson, J.2
Ransohoff, R.M.3
-
11
-
-
0342906187
-
Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
-
Lucchinetti C, Bruck W, Parisi J, et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neural 2000; 47:707-717.
-
(2000)
Ann Neural
, vol.47
, pp. 707-717
-
-
Lucchinetti, C.1
Bruck, W.2
Parisi, J.3
-
12
-
-
0033695060
-
Immunological time-course of gadolinium-enhancing MRI lesions in patients with multiple sclerosis
-
Giovannoni G, Silver NC, Good CD, et al. Immunological time-course of gadolinium-enhancing MRI lesions in patients with multiple sclerosis. Eur Neural 2000; 44:222-228.
-
(2000)
Eur Neural
, vol.44
, pp. 222-228
-
-
Giovannoni, G.1
Silver, N.C.2
Good, C.D.3
-
13
-
-
33845294412
-
Remyelination is extensive in a subset of multiple sclerosis patients
-
Patrikios P, Stadelmann C, Kutzelnigg A, et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006; 129 (Pt 12):3165-3172.
-
(2006)
Brain
, vol.129
, Issue.PART 12
, pp. 3165-3172
-
-
Patrikios, P.1
Stadelmann, C.2
Kutzelnigg, A.3
-
14
-
-
33947547648
-
-
Albert M, Antel J, Bruck W, Stadelmann C. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 2007; 17:129-138. It is known that MS lesions variably remyelinate; this work highlights that it may be extensive in the cortex, to a degree that in some regions tissues may even appear normal on light microscopy.
-
Albert M, Antel J, Bruck W, Stadelmann C. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 2007; 17:129-138. It is known that MS lesions variably remyelinate; this work highlights that it may be extensive in the cortex, to a degree that in some regions tissues may even appear normal on light microscopy.
-
-
-
-
15
-
-
34247862406
-
Remyelination can be extensive in multiple sclerosis despite a long disease course
-
Patani R, Balaratnam M, Vora A, Reynolds R. Remyelination can be extensive in multiple sclerosis despite a long disease course. Neuropathol Appl Neurobiol 2007; 33:277-287.
-
(2007)
Neuropathol Appl Neurobiol
, vol.33
, pp. 277-287
-
-
Patani, R.1
Balaratnam, M.2
Vora, A.3
Reynolds, R.4
-
16
-
-
0036407449
-
Choline is increased in prelesional normal appearing white matter in multiple sclerosis
-
Tartaglia MC, Narayanan S, De Stefano N, et al. Choline is increased in prelesional normal appearing white matter in multiple sclerosis. J Neural 2002; 249:1382-1390.
-
(2002)
J Neural
, vol.249
, pp. 1382-1390
-
-
Tartaglia, M.C.1
Narayanan, S.2
De Stefano, N.3
-
17
-
-
33749681502
-
Normal-appearing white matter changes vary with distance to lesions in multiple sclerosis
-
Vrenken H, Geurts JJ, Knol DL, et al. Normal-appearing white matter changes vary with distance to lesions in multiple sclerosis. AJNR Am J Neuroradiol 2006; 27:2005-2011.
-
(2006)
AJNR Am J Neuroradiol
, vol.27
, pp. 2005-2011
-
-
Vrenken, H.1
Geurts, J.J.2
Knol, D.L.3
-
18
-
-
39749200152
-
Disability and T2 MRI lesions: A 20-year follow-up of patients with relapse onset of multiple sclerosis
-
Rsniku LK, Brex PA, Altmann DR, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain 2008; 131 (Pt 3):808-817.
-
(2008)
Brain
, vol.131
, Issue.PART 3
, pp. 808-817
-
-
Rsniku, L.K.1
Brex, P.A.2
Altmann, D.R.3
-
19
-
-
54849431592
-
Gray matter atrophy is related to long-term disability in multiple sclerosis
-
Fisniku LK, Chard DT, Jackson JS, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol 2008; 64:247-254.
-
(2008)
Ann Neurol
, vol.64
, pp. 247-254
-
-
Fisniku, L.K.1
Chard, D.T.2
Jackson, J.S.3
-
20
-
-
0037828315
-
Subpial demyelination in the cerebral cortex of multiple sclerosis patients
-
Ba L, Vedeler CA, Nyland HI, et al. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 2003; 62:723-732.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 723-732
-
-
Ba, L.1
Vedeler, C.A.2
Nyland, H.I.3
-
21
-
-
39049089920
-
Effect of intravenous methylpredni-solone on the number, size and confluence of plaques in relapsing-remitting multiple sclerosis
-
Zivadinov R, Zorzon M, De Masi R, et al. Effect of intravenous methylpredni-solone on the number, size and confluence of plaques in relapsing-remitting multiple sclerosis. J Neurol Sci 2008; 267:28-35.
-
(2008)
J Neurol Sci
, vol.267
, pp. 28-35
-
-
Zivadinov, R.1
Zorzon, M.2
De Masi, R.3
-
22
-
-
34548647704
-
Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
-
Khaleeli Z, Sastre-Garriga J, Ciccarelli O, et al. Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2007; 78:1076-1082.
-
(2007)
J Neurol Neurosurg Psychiatry
, vol.78
, pp. 1076-1082
-
-
Khaleeli, Z.1
Sastre-Garriga, J.2
Ciccarelli, O.3
-
23
-
-
34848861123
-
Imaging correlates of axonal swelling in chronic multiple sclerosis brains
-
Fisher E, Chang A, Fox RJ, et al. Imaging correlates of axonal swelling in chronic multiple sclerosis brains. Ann Neurol 2007; 62:219-228.
-
(2007)
Ann Neurol
, vol.62
, pp. 219-228
-
-
Fisher, E.1
Chang, A.2
Fox, R.J.3
-
24
-
-
37549070224
-
Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection
-
Zeis T, Graumann U, Reynolds R, Schaeren-Wiemers N. Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain 2008; 131 (Pt 1):288-303.
-
(2008)
Brain
, vol.131
, Issue.PART 1
, pp. 288-303
-
-
Zeis, T.1
Graumann, U.2
Reynolds, R.3
Schaeren-Wiemers, N.4
-
25
-
-
35348874326
-
Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis
-
Calabrese M, De Stefano N, Atzori M, et al. Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Arch Neurol 2007; 64:1416-1422.
-
(2007)
Arch Neurol
, vol.64
, pp. 1416-1422
-
-
Calabrese, M.1
De Stefano, N.2
Atzori, M.3
-
26
-
-
0345255005
-
Dirty-appearing white matter in multiple sclerosis: Volumetric MR imaging and magnetization transfer ratio histogram analysis
-
Ge Y, Grossman Rl, Babb JS, et al. Dirty-appearing white matter in multiple sclerosis: volumetric MR imaging and magnetization transfer ratio histogram analysis. AJNR Am J Neuroradiol 2003; 24:1935-1940.
-
(2003)
AJNR Am J Neuroradiol
, vol.24
, pp. 1935-1940
-
-
Ge, Y.1
Grossman, R.2
Babb, J.S.3
-
27
-
-
58549119330
-
Dirty-appearing white matter in multiple sclerosis: Preliminary observations of myelin phospholipid and axonal loss
-
This work suggests that within nonlesional white matter, there may still be localized differences in the pathological impact of MS
-
Moore GR, Laule C, Mackay A, et al. Dirty-appearing white matter in multiple sclerosis: preliminary observations of myelin phospholipid and axonal loss. J Neurol 2008; 255:1802-1811. This work suggests that within nonlesional white matter, there may still be localized differences in the pathological impact of MS.
-
(2008)
J Neurol
, vol.255
, pp. 1802-1811
-
-
Moore, G.R.1
Laule, C.2
Mackay, A.3
-
28
-
-
0034646386
-
A Wallerian degeneration pattern in patients at risk for MS
-
Simon JH, Kinkel RP, Jacobs L, et al. A Wallerian degeneration pattern in patients at risk for MS. Neurology 2000; 54:1155-1160.
-
(2000)
Neurology
, vol.54
, pp. 1155-1160
-
-
Simon, J.H.1
Kinkel, R.P.2
Jacobs, L.3
-
29
-
-
21344472775
-
Optic radiation changes after optic neuritis detected by tractography-based group mapping
-
Ciccarelli O, Toosy AT, Hickman SJ, et al. Optic radiation changes after optic neuritis detected by tractography-based group mapping. Hum Brain Mapp 2005; 25:308-316.
-
(2005)
Hum Brain Mapp
, vol.25
, pp. 308-316
-
-
Ciccarelli, O.1
Toosy, A.T.2
Hickman, S.J.3
-
30
-
-
33645065104
-
Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis
-
Audoin B, Fernando KT, Swanton JK, et al. Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis. Brain 2006; 129 (Pt 4):1031-1039.
-
(2006)
Brain
, vol.129
, Issue.PART 4
, pp. 1031-1039
-
-
Audoin, B.1
Fernando, K.T.2
Swanton, J.K.3
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