HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603 Alleles are Associated With More Severe Disease Outcome on Mri in Patients With Multiple Sclerosis

International Review of Neurobiology

Volumn 79, Issue , 2007, Pages 521-535

  Zivadinov, Robert ^a   Uxa, Laura ^b   Bratina, Alessio ^c   Bosco, Antonio ^c   Srinivasaraghavan, Bhooma ^a   Minagar, Alireza ^d   Ukmar, Maja ^c   Benedetto, Su yen ^b   Zorzon, Marino ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b Blood Transfusion Center   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ ANTIGEN; HLA DQB1 PROTEIN, HUMAN; HLA-DQB1 PROTEIN, HUMAN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN; CLASSIFICATION; DISABILITY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOSPITALIZATION; HUMAN; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; REGRESSION ANALYSIS;

ADULT; BRAIN; DISABILITY EVALUATION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MULTIPLE SCLEROSIS; REGRESSION ANALYSIS; SEVERITY OF ILLNESS INDEX;

EID: 34248680532     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(07)79023-2     Document Type: Review

References (48)

1. Ashburner J., and Friston K.J. Voxel-based morphometry-the methods. Neuroimage 11 (2000) 805-821
2. Carone D.A., Benedict R.H., Dwyer M.G., Cookfair D.L., Srinivasaraghavan B., Tjoa C.W., and Zivadinov R. Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS. Neuroimage 29 (2006) 505-514
3. Chapman J., Vinokurov S., Achiron A., Karussis D.M., Mitosek-Szewczyk K., Birnbaum M., Michaelson D.M., and Korczyn A.D. APOE genotype is a major predictor of long-term progression of disability in MS. Neurology 56 (2001) 312-316
4. Coraddu F., Lai M., Mancosu C., Cocco E., Sawcer S., Setakis E., Compston A., and Marrosu M.G. A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis. J. Neuroimmunol. 143 (2003) 120-123
5. Crusius J.B., Pena A.S., Van Oosten B.W., Bioque G., Garcia A., Dijkstra C.D., and Polman C.H. Interleukin-1 receptor antagonist gene polymorphism and multiple sclerosis. Lancet 346 (1995) 979-980
6. Dyment D.A., Ebers G.C., and Sadovnick A.D. Genetics of multiple sclerosis. Lancet Neurol. 3 (2004) 104-110
7. Enzinger C., Ropele S., Smith S., Strasser-Fuchs S., Poltrum B., Schmidt H., Matthews P.M., and Fazekas F. Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4. Ann. Neurol. 55 (2004) 563-569
8. Fainardi E., Granieri E., Tola M.R., Melchiorri L., Vaghi L., Rizzo R., Castellazzi M., Ceruti S., Paolino E., and Baricordi O.R. Clinical and MRI disease activity in multiple sclerosis are associated with reciprocal fluctuations in serum and cerebrospinal fluid levels of soluble HLA class I molecules. J. Neuroimmunol. 133 (2002) 151-159
9. Fainardi E., Rizzo R., Melchiorri L., Vaghi L., Castellazzi M., Marzola A., Govoni V., Paolino E., Tola M.R., Granieri E., and Baricordi O.R. Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing-remitting multiple sclerosis: Relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings. J. Neuroimmunol. 142 (2003) 149-158
10. Fainardi E., Rizzo R., Melchiorri L., Castellazzi M., Paolino E., Tola M.R., Granieri E., and Baricordi O.R. Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis. Mult. Scler. 12 (2006) 2-12
11. Fazekas F., Strasser-Fuchs S., Schmidt H., Enzinger C., Ropele S., Lechner A., Flooh E., Schmidt R., and Hartung H.P. Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 69 (2000) 25-28
12. Fazekas F., Strasser-Fuchs S., Kollegger H., Berger T., Kristoferitsch W., Schmidt H., Enzinger C., Schiefermeier M., Schwarz C., Kornek B., Reindl M., Huber K., et al. Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis. Neurology 57 (2001) 853-857
13. Frederiksen J.L., Madsen H.O., Ryder L.P., Larsson H.B., Morling N., and Svejgaard A. HLA typing in acute optic neuritis. Relation to multiple sclerosis and magnetic resonance imaging findings. Arch. Neurol. 54 (1997) 76-80
14. Goedde R., Sawcer S., Boehringer S., Miterski B., Sindern E., Haupts M., Schimrigk S., Compston A., and Epplen J.T. A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers. Hum. Genet. 111 (2002) 270-277
15. Haines J.L., Ter-Minassian M., Bazyk A., Gusella J.F., Kim D.J., Terwedow H., Pericak-Vance M.A., Rimmler J.B., Haynes C.S., Roses A.D., Lee A., Shaner B., et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat. Genet. 13 (1996) 469-471
16. Haines J.L., Terwedow H.A., Burgess K., Pericak-Vance M.A., Rimmler J.B., Martin E.R., Oksenberg J.R., Lincoln R., Zhang D.Y., Banatao D.R., Gatto N., Goodkin D.E., et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum. Mol. Genet. 7 (1998) 1229-1234
17. Hauser S.L., Oksenberg J.R., Lincoln R., Garovoy J., Beck R.W., Cole S.R., Moke P.S., Kip K.E., Gal R.L., and Long D.T. Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group. Neurology 54 (2000) 1859-1861
18. Hensiek A.E., Sawcer S.J., Feakes R., Deans J., Mander A., Akesson E., Roxburgh R., Coraddu F., Smith S., and Compston D.A. HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 72 (2002) 184-187
19. Hensiek A.E., Roxburgh R., Smilie B., Coraddu F., Akesson E., Holmans P., Sawcer S.J., and Compston D.A. Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis. J. Neuroimmunol. 143 (2003) 25-30
20. Herrera B.M., and Ebers G.C. Progress in deciphering the genetics of multiple sclerosis. Curr. Opin. Neurol. 16 (2003) 253-258
21. Kantarci O.H., de Andrade M., and Weinshenker B.G. Identifying disease modifying genes in multiple sclerosis. J. Neuroimmunol. 123 (2002) 144-159
22. Kelly M.A., Cavan D.A., Penny M.A., Mijovic C.H., Jenkins D., Morrissey S., Miller D.H., Barnett A.H., and Francis D.A. The influence of HLA-DR and -DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome. Hum. Immunol. 37 (1993) 185-191
23. Liguori M., Sawcer S., Setakis E., Compston A., Giordano M., D'Alfonso S., Mellai M., Malferrari G., Trojano M., Livrea P., De Robertis F., Massacesi L., et al. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population. J. Neuroimmunol. 143 (2003) 97-100
24. Lucchinetti C., Bruck W., Parisi J., Scheithauer B., Rodriguez M., and Lassmann H. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases. Brain 122 Pt. 12 (1999) 2279-2295
25. Lucchinetti C., Bruck W., Parisi J., Scheithauer B., Rodriguez M., and Lassmann H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann. Neurol. 47 (2000) 707-717
26. Lucchinetti C., Bruck W., and Noseworthy J. Multiple sclerosis: Recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr. Opin. Neurol. 14 (2001) 259-269
27. Luomala M., Elovaara I., Ukkonen M., Koivula T., and Lehtimaki T. The combination of HLA-DR1 and HLA-DR53 protects against MS. Neurology 56 (2001) 383-385
28. Marrosu M.G., Murru R., Murru M.R., Costa G., Zavattari P., Whalen M., Cocco E., Mancosu C., Schirru L., Solla E., Fadda E., Melis C., et al. Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia. Hum. Mol. Genet. 10 (2001) 2907-2916
29. Masterman T., Ligers A., Olsson T., Andersson M., Olerup O., and Hillert J. HLA-DR15 is associated with lower age at onset in multiple sclerosis. Ann. Neurol. 48 (2000) 211-219
30. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50 (2001) 121-127
31. Miller D.H., Barkhof F., Berry I., Kappos L., Scotti G., and Thompson A.J. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted action guidelines. J. Neurol. Neurosurg. Psychiatry 54 (1991) 683-688
32. Nilsson P., Larsson E.M., Maly-Sundgren P., Perfekt R., and Sandberg-Wollheim M. Predicting the outcome of optic neuritis evaluation of risk factors after 30 years of follow-up. J. Neurol. 252 (2005) 396-402
33. Runmarker B., and Andersen O. Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up. Brain 116 Pt. 1 (1993) 117-134
34. Sanfilipo M.P., Benedict R.H., Zivadinov R., and Bakshi R. Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: The proportion vs. residual method. Neuroimage 22 (2004) 1732-1743
35. Sawcer S., Maranian M., Setakis E., Curwen V., Akesson E., Hensiek A., Coraddu F., Roxburgh R., Sawcer D., Gray J., Deans J., Goodfellow P.N., et al. A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility. Brain 125 (2002) 1337-1347
36. Schreiber K., Otura A.B., Ryder L.P., Madsen H.O., Jorgensen O.S., Svejgaard A., and Sorensen P.S. Disease severity in Danish multiple sclerosis patients evaluated by MRI and three genetic markers (HLA-DRB1*1501, CCR5 deletion mutation, apolipoprotein E). Mult. Scler. 8 (2002) 295-298
37. Sellebjerg F., Madsen H.O., Jensen C.V., Jensen J., and Garred P. CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis. J. Neuroimmunol. 102 (2000) 98-106
38. Soderstrom M., Lindqvist M., Hillert J., Kall T.B., and Link H. Optic neuritis: Findings on MRI, CSF examination and HLA class II typing in 60 patients and results of a short-term follow-up. J. Neurol. 241 (1994) 391-397
39. Soderstrom M., Ya-Ping J., Hillert J., and Link H. Optic neuritis: Prognosis for multiple sclerosis from MRI, CSF, and HLA findings. Neurology 50 (1998) 708-714
40. Thompson A.J., Montalban X., Barkhof F., Brochet B., Filippi M., Miller D.H., Polman C.H., Stevenson V.L., and McDonald W.I. Diagnostic criteria for primary progressive multiple sclerosis: A position paper. Ann. Neurol. 47 (2000) 831-835
41. Weinshenker B.G., Santrach P., Bissonet A.S., McDonnell S.K., Schaid D., Moore S.B., and Rodriguez M. Major histocompatibility complex class II alleles and the course and outcome of MS: A population-based study. Neurology 51 (1998) 742-747
42. Wekerle H., and Hohlfeld R. Molecular mimicry in multiple sclerosis. N. Engl. J. Med. 349 (2003) 185-186
43. Yamasaki K., Horiuchi I., Minohara M., Kawano Y., Ohyagi Y., Yamada T., Mihara F., Ito H., Nishimura Y., and Kira J. HLA-DPB1*0501-associated opticospinal multiple sclerosis: Clinical, neuroimaging and immunogenetic studies. Brain 122 Pt. 9 (1999) 1689-1696
44. Zivadinov R. Evidence for neuroprotection in multiple sclerosis: Can imaging techniques measure neuroprotection and remyelination?. Neurology (2006) (in press)
45. Zivadinov R., and Bakshi R. Role of MRI in multiple sclerosis II: Brain and spinal cord atrophy. Front. Biosci. 9 (2004) 647-664
46. Zivadinov R., Rudick R.A., De Masi R., Nasuelli D., Ukmar M., Pozzi-Mucelli R.S., Grop A., Cazzato G., and Zorzon M. Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 57 (2001) 1239-1247
47. Zivadinov R., Sepcic J., Nasuelli D., De Masi R., Bragadin L.M., Tommasi M.A., Zambito-Marsala S., Moretti R., Bratina A., Ukmar M., Pozzi-Mucelli R.S., Grop A., et al. A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 70 (2001) 773-780
48. Zivadinov R., Uxa L., Zacchi T., Nasuelli D., Ukmar M., Furlan C., Pozzi-Mucelli R., Tommasi M.A., Locatelli L., Ulivi S., Bratina A., Bosco A., et al. HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis. J. Neurol. 250 (2003) 1099-1106