A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen

Infection and Immunity

Volumn 74, Issue 1, 2006, Pages 786-789

  Parra, Marcela ^a   Cadieux, Nathalie ^a   Pickett, Thames ^a,b   Dheenadhayalan, Veerabadran ^a   Brennan, Michael J ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIAL PROTEIN; DNA VACCINE; EPITOPE; MYCOBACTERIUM VACCINE; PE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; CROSS IMMUNITY; GENE EXPRESSION; IMMUNITY; IMMUNIZATION; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; ELECTROPHORESIS, AGAR GEL; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM AVIUM; MYCOBACTERIUM TUBERCULOSIS; T-LYMPHOCYTE SUBSETS; TUBERCULOSIS; TUBERCULOSIS VACCINES;

EID: 29644432453     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.1.786-789.2006     Document Type: Article

References (17)

1. Brennan, M. J., G, Delogu, Y. Chen, S. Bardarov, J. Kriakov, M. Alavi, and W. R. Jacobs, Jr. 2001. Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells. Infect. Immun. 69:7326-7333.
2. Brennan, M. J., and G. Delogu. 2002. The PE multigene family, a 'molecular mantra' for mycobacteria. Trends Microbiol. 10:246-249.
3. Brennan, M. J., C. Espitia, and N. C. Gey van Pittius. 2005. The PE and PPE multigene families of mycobacteria, p. 513-525. In S. T. Cole, K. D. Eisenach, D. N, McMurray, and W. R. Jacobs, Jr. (ed.), Tuberculosis and the tubercle bacillus. ASM Press, Washington, D.C.
4. Brusasca, P. N., R. Colangeli, K. P. Lyashchenko, X. Zhao, M. Vogelstein, J. S. Spencer, D. N. McMurray, and M. L. Gennaro. 2001. Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome. Scand. J. Immunol. 54:448-452.
5. Cockle, P. J., S. V. Gordon, A. Lalvani, B. M. Buddle, R. G. Hewinson, and M. Vordermeier. 2002. Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics. Infect. Immun. 70:6996-7003.
6. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry III, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, and B. G. Barrell. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
7. Delogu, G., A. Li, C. Repique, F. Collins, and S. L. Morris. 2002. DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect. Immun. 70:292-302.
8. Delogu, G., C. Pusceddu, A. Bua, G. Fadda, M. J. Brennan, and S. Zanetti. 2004. Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Mol. Microbiol. 52:725-733.
9. Dheenadhayalan, V., G. Delogu, and M. J. Brennan. 30 September 2005. Expression of PE-PGRS in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survival. Microbes Infect. [Online.] 10.1016/j.micinf.2005.06.021.
10. Fisher, M. A., B. B. Plikaytis, and T. M. Shinnick. 2002. Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J. Bacteriol. 184:4025-4032.
11. Fleischmann, R. D., D. Alland, J. A. Eisen, L. Carpenter, O. White, J. Peterson, R. DeBoy, R. Dodson, M. Gwinn, D. Haft, E. Hickey, J. F. Kolonay, W. C. Nelson, L. A. Umayam, M. Ermolaeva, S. L. Salzberg, A. Delcher, T. Utterback, J. Weidman, H. Khouri J. Gill, A. Mikula, W. Bishai, W. R. Jacobs, Jr., J. C. Venter, and C. M. Fraser. 2002. Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains. J. Bacteriol. 184:5479-5490.
12. Flores, J., and C. Espitia. 2003. Differential expression of PE and PE-PGRS genes in Mycobacterium tuberculosis strains. Gene 318:75-81.
13. Gey van Pittius, N. C., J. Gamieldien, W. Hide, G. D. Brown, R. J. Siezen, and A. D. Beyers. 19 September 2001, posting date. The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G + C gram-positive bacteria. Genome Biol. 2:RESEARCH0044.
14. Gordon, S. V., K. Eiglmeier, T. Garnier, R. Brosch, J. Parkhill, B. Barrell, S. T. Cole, and R. G. Hewinson. 2001. Genomics of Mycobacterium bovis. Tuberculosis (Edinburgh) 81:157-163.
15. Parra, M. T. Pickett, G. Delogu, V. Dheenadhayalan, A.-S. Debrie, C. Locht, and M. J. Brennan. 2004. The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis. Infect. Immun. 72:6799-6805.
16. Rodriguez, G. M., M. I. Voskuil, B. Gold, G. K. Schoolnik, and I. Smith. 2002. ideR, an essential gene in Mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect. Immun. 70:3371-3381.
17. Voskuil, M. I., D. Schnappinger, R. Rutherford, Y. Liu, and G. K. Schoolnik. 2004. Regulation of the PE/PPE genes. Tuberculosis (Edinburgh) 84:256-262.