Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury

American Journal of Pathology

Volumn 174, Issue 6, 2009, Pages 2182-2189

  Van Zoelen, Marieke A D ^a   Florquin, Sandrine ^a   De Beer, Regina ^a   Pater, Jennie M ^a   Verstege, Marleen I ^a   Meijers, Joost C M ^a   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 6; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; FEMALE; GRANULOCYTE; HYPEROXIA; LUNG INJURY; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; RESPIRATORY FAILURE;

EID: 67049137446     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.080914     Document Type: Article

References (38)

1. Wheeler AP, Bernard GR: Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 2007, 369:1553-1564 (Pubitemid 46670280)
2. Leaver SK, Evans TW: Acute respiratory distress syndrome. BMJ 2007, 335:389-394 (Pubitemid 47359318)
3. Carvalho CR, Paula Pinto SG, Maranhao B, Bethlem EP: Hyperoxia and lung disease. Curr Opin Pulm Med 1998, 4:300-304 (Pubitemid 128353512)
4. Deng H, Mason SN, Auten RL Jr: Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Am J Respir Crit Care Med 2000, 162:2316-2323 (Pubitemid 32051706)
5. Auten RL, Richardson RM, White JR, Mason SN, Vozzelli MA, Whorton MH: Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther 2001, 299:90-95 (Pubitemid 32905122)
6. Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Keane MP, Strieter RM: CXCR2 is critical to hyperoxia-induced lung injury. J Immunol 2004, 172:3860-3868 (Pubitemid 38337973)
7. Perkowski S, Scherpereel A, Murciano JC, Arguiri E, Solomides CC, Albelda SM, Muzykantov V, Christofidou-Solomidou M: Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am J Physiol Lung Cell Mol Physiol 2006, 291:L1050-L1058 (Pubitemid 44772067)
8. Gyetko MR, Sud S, Kendall T, Fuller JA, Newstead MW, Standiford TJ: Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol 2000, 165:1513-1519 (Pubitemid 30604586)
9. Rijneveld AW, Levi M, Florquin S, Speelman P, Carmeliet P, van der Poll T: reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood 2004, 103:1702-1709
10. Blasi F, Carmeliet P: uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002, 3:932-943 (Pubitemid 35477371)
11. Mondino A, Blasi F: uPA and uPAR in fibrinolysis, immunity and pathology. Trends Immunol 2004, 25:450-455 (Pubitemid 38951087)
12. Leemans JC, Juffermans NP, Florquin S, van Rooijen N, Vervoordeldonk MJ, Verbon A, van Deventer SJ, van der Poll T: Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J Immunol 2001, 166:4604-4611 (Pubitemid 32233746)
13. Leemans JC, Florquin S, Heikens M, Pals ST, van der Rooijen N, van der Poll T: CD44 is a macrophage binding site for Mycobacterium tuberculosis that mediates macrophage recruitment and protective immunity against tuberculosis. J Clin Invest 2003, 111:681-689 (Pubitemid 36278586)
14. Knapp S, Leemans JC, Florquin S, Branger J, Maris NA, Pater J, van Rooijen N, van der Poll T: Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. Am J Respir Crit Care Med 2003, 167:171-179 (Pubitemid 36076076)
15. Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, Speelman P, Reitsma PH, Ten Cate H, van der Poll T: Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood 2004, 103:1702-1709 (Pubitemid 38268962)
16. Weijer S, Schoenmakers SH, Florquin S, Levi M, Vlasuk GP, Rote WE, Reitsma PH, Spek CA, van der Poll T: Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice. J Infect Dis 2004, 189:2308-2317 (Pubitemid 38757205)
17. Barazzone C, Belin D, Piguet PF, Vassalli JD, Sappino AP: Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J Clin Invest 1996, 98:2666-2673 (Pubitemid 26427390)
18. Matthew E, Pun R, Simonich M, Iwamoto H, Dedman J: Cyclosporin A protects lung function from hyperoxic damage. Am J Physiol 1999, 276:L786-L795 (Pubitemid 29249632)
19. Henderson RF: Use of bronchoalveolar lavage to detect respiratory tract toxicity of inhaled material. Exp Toxicol Pathol 2005, 57 Suppl 1:155-159 (Pubitemid 40884488)
20. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA: Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med 2006, 173:1008-1015
21. Gunther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, Grimminger F, Walmrath D, Temmesfeld-Wollbruck B, Seeger W: Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. Am J Respir Crit Care Med 2000, 161:454-462 (Pubitemid 30129452)
22. Abraham E: Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol 2000, 22:401-404 (Pubitemid 30343338)
23. ter Horst SA, Walther FJ, Poorthuis BJ, Hiemstra PS, Wagenaar GT: Inhaled nitric oxide attenuates pulmonary inflammation and fibrin deposition and prolongs survival in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol 2007, 293:L35-L44
24. Plesner T, Ploug M, Ellis V, Ronne E, Hoyer-Hansen G, Wittrup M, Pedersen TL, Tscherning T, Dano K, Hansen NE: The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils. Blood 1994, 83:808-815 (Pubitemid 24043743)
25. Kim MH, Cho HS, Jung M, Hong MH, Lee SK, Shin BA, Ahn BW, Jung YD: Extracellular signal-regulated kinase and AP-1 pathways are involved in reactive oxygen species-induced urokinase plasminogen activator receptor expression in human gastric cancer cells. Int J Oncol 2005, 26:1669-1674
26. Doerschuk CM, Tasaka S, Wang Q: CD11/CD18-dependent and -independent neutrophil emigration in the lungs: how do neutrophils know which route to take? Am J Respir Cell Mol Biol 2000, 23:133-136
27. Wagner JG, Roth RA: Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature. Pharmacol Rev 2000, 52:349-374
28. Gyetko MR, Sitrin RG, Fuller JA, Todd RF III, Petty H, Standiford TJ: Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J Leukoc Biol 1995, 58:533-538
29. May AE, Kanse SM, Lund LR, Gisler RH, Imhof BA, Preissner KT: Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo. J Exp Med 1998, 188:1029-1037 (Pubitemid 28443326)
30. Doerschuk CM, Winn RK, Coxson HO, Harlan JM: CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol 1990, 144:2327-2333 (Pubitemid 20106576)
31. Rijneveld AW, de Vos AF, Florquin S, Verbeek JS, van der Poll T: CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia. J Infect Dis 2005, 191:1755-1760 (Pubitemid 40656765)
32. Keeney SE, Mathews MJ, Haque AK, Rudloff HE, Schmalstieg FC: Oxygen-induced lung injury in the guinea pig proceeds through CD18-independent mechanisms. Am J Respir Crit Care Med 1994, 149:311-319 (Pubitemid 124000015)
33. Shasby DM, Fox RB, Harada RN, Repine JE: Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. J Appl Physiol 1982, 52:1237-1244 (Pubitemid 12055078)
34. Boyce NW, Campbell D, Holdsworth SR: Granulocyte independence of pulmonary oxygen toxicity in the rat. Exp Lung Res 1989, 15:491-498
35. Liao L, Ning Q, Li Y, Wang W, Wang A, Wei W, Liu X, Auten RL, Tanswell AK, Luo X: CXCR2 blockade reduces radical formation in hyperoxia-exposed newborn rat lung. Pediatr Res 2006, 60:299-303 (Pubitemid 44267742)
36. Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM: Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. Am J Respir Cell Mol Biol 2006, 35:628-638 (Pubitemid 44901852)
37. Beaufort N, Leduc D, Eguchi H, Mengele K, Hellmann D, Masegi T, Kamimura T, Yasuoka S, Fend F, Chignard M, Pidard D: The human airway trypsin-like protease modulates the urokinase receptor (uPAR. CD87) structure and functions. Am J Physiol Lung Cell Mol Physiol 2007, 292:L1263-L1272 (Pubitemid 47084872)
38. Gyetko MR, Sud S, Sonstein J, Polak T, Sud A, Curtis JL: Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA. J Immunol 2001, 167:5539-5542 (Pubitemid 33062741)