Prolactin as a modulator of platelet function and thrombosis: The end of the story, or a new beginning?

Thrombosis and Haemostasis

Volumn 101, Issue 6, 2009, Pages 991-992

  Heida, Nana Maria ^a   Schäfer, Katrin ^a   Konstantinides, Stavros ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADIPOCYTOKINE; ADRENALIN; COLLAGEN; DUAL SPECIFICITY PHOSPHATASE 2; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; LAMININ; LEPTIN; NEUROLEPTIC AGENT; PADGEM PROTEIN; PHOSPHOLIPASE C BETA; PHOSPHOLIPASE C GAMMA; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN KINASE C; SEROTONIN; THROMBIN; THROMBOXANE A2; VON WILLEBRAND FACTOR;

ACUTE CORONARY SYNDROME; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; EDITORIAL; ENZYME ACTIVATION; HORMONE ACTION; HUMAN; HYPOPHYSIS TUMOR; NONHUMAN; OBESITY; PATHOGENESIS; PREGNANCY; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; PUBLICATION; RISK FACTOR; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE FUNCTION; THROMBOGENESIS; THROMBOSIS; VENOUS THROMBOEMBOLISM; WESTERN BLOTTING; ANIMAL; FEEDBACK SYSTEM; FEMALE; METABOLISM; MOUSE; PATHOLOGY; PREGNANCY COMPLICATION; SIGNAL TRANSDUCTION; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; DUAL SPECIFICITY PHOSPHATASE 2; FEEDBACK, PHYSIOLOGICAL; FEMALE; HUMANS; MICE; P-SELECTIN; PLATELET ACTIVATION; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROLACTIN; SIGNAL TRANSDUCTION; THROMBOSIS;

EID: 67049110263     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-04-0275     Document Type: Editorial

References (27)

1. Reuwer AQ, Nieuwland R, Frenandez I, et al. Prolactin does not affect human platelet aggregation or secretion. Thromb Haemost 2009; 101: 1119-1127.
2. Raaz D, Wallaschofski H, Stumpf C, et al. Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression. Horm Metab Res 2006; 38: 767-772. (Pubitemid 44885431)
3. Wallaschofski H, Lohmann T, Hild E, et al. Enhanced platelet activation by prolactin in patients with ischemic stroke. Thromb Haemost 2006; 96: 38-44. (Pubitemid 44160869)
4. Wallaschofski H, Kobsar A, Sokolova O, et al. Coactivation of platelets by prolactin or leptin - pathophysiological findings and clinical implications. Horm Metab Res 2004; 36: 1-6. (Pubitemid 38283186)
5. Wallaschofski H, Kobsar A, Koksch M, et al. Prolactin receptor signaling during platelet activation. Horm Metab Res 2003; 35: 228-235. (Pubitemid 36754199)
6. Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-2494.
7. Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-1234. (Pubitemid 35373553)
8. Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 2008; 28: 403-412.
9. Bodary PF. Links between adipose tissue and thrombosis in the mouse. Arterioscler Thromb Vasc Biol 2007; 27: 2284-2291. (Pubitemid 350203941)
10. Bodary PF, Westrick RJ, Wickenheiser KJ, et al. Effect of leptin on arterial thrombosis following vascular injury in mice. Jama-Journal of the American Medical Association 2002; 287: 1706-1709. (Pubitemid 34289223)
11. Konstantinides S, Schäfer K, Koschnick S, et al. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108:1533-1540 (Pubitemid 33091991)
12. Konstantinides S, Schäfer K, Neels JG, et al. Inhibition of endogenous leptin protects mice from arterial and venous thrombosis. Arterioscler Thromb Vasc Biol 2004; 24: 2196-2201. (Pubitemid 39482452)
13. Dellas C, Schäfer K, Rohm IK, et al. Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2. Thromb Haemost 2007; 98: 1063-1071. (Pubitemid 350091136)
14. Elbatarny HS, Maurice DH. Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex. Am J Physiol Endocrinol Metab 2005; 289: E695-E702. (Pubitemid 41356093)
15. Corsonello A, Malara A, De Domenico D, et al. Identifying pathways involved in leptin-dependent aggregation of human platelets. Int J Obes Relat Metab Disord 2004; 28: 979-984. (Pubitemid 38998702)
16. Dellas C, Schäfer K, Rohm I, et al. Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thromb Haemost 2008; 100: 1123-1129.
17. Kato H, Kashiwagi H, Shiraga M, et al. Adiponectin acts as an endogenous antithrombotic factor. Arterioscler Thromb Vasc Biol 2006; 26: 224-22430. (Pubitemid 43732254)
18. Zabeau L, Lavens D, Peelman F, et al. The ins and outs of leptin receptor activation. FEBS Lett 2003; 546: 45-50. (Pubitemid 36782280)
19. Wallaschofski H, Kobsar A, Sokolova O, et al. Differences in platelet activation by prolactin and leptin. Horm Metab Res 2004; 36: 453-457. (Pubitemid 39119248)
20. Atmaca A, Gurlek A, Dagdelen S, et al. Hyperprolactinemia of pregnancy is not associated with increased in vivo platelet activity and shortened in vitro bleeding times. Exp Clin Endocrinol Diabetes 2006; 114: 188-191. (Pubitemid 43845196)
21. Gainsford T, Willson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-14568. (Pubitemid 26419007)
22. Nakata M, Yada T, Soejima N, et al. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-429. (Pubitemid 29061122)
23. Giandomenico G, Dellas C, Czekay RP, et al. The leptin receptor system of human platelets. J Thromb Haemost 2005; 3: 1042-1049. (Pubitemid 41632837)
24. Kamikubo Y, Dellas C, Loskutoff DJ, et al. Contribution of leptin receptor N-linked glycans to leptin binding. Biochem J 2008; 410: 595-604.
25. Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004; 59: 305-331.
26. Rafail S, Ritis K, Schäfer K, et al. Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement. Thromb Res 2008; 122: 366-375.
27. Napoleone E, DI SA, Amore C, et al. Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk? J Thromb Haemost 2007; 5: 1462-1468.