Syntheses of 5-chlorouracils/thymines with 1-[phosphono(methyl/ difluoromethyl)]-1,2-unsaturated-moiety-substituted methyl groups at N(1) and human thymidine phosphorylase inhibitory activity

Helvetica Chimica Acta

Volumn 92, Issue 5, 2009, Pages 823-838

  Birck, Matthew R ^b,c   Clinch, Keith ^a   Gainsford, Graeme J ^a   Schramm, Vern L ^b   Tyler, Peter C ^a  

^a CALLAGHAN INNOVATION   (New Zealand)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c Homeland Security   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPENTENE; FREE ROTATION; INHIBITORY ACTIVITY; INTER-ATOMIC DISTANCES; METHYL GROUP; PHOSPHONATE GROUP; PHOSPHONATES; POTENTIAL INHIBITORS; THYMIDINE PHOSPHORYLASE; TRANSITION STATE;

BENZENE; ETHYLENE; HYDROCARBONS; PHOSPHORYLATION;

GROUP TECHNOLOGY;

5 CHLOROURACIL DERIVATIVE; BENZENE; CYCLOPENTENE DERIVATIVE; DISODIUM [2 [(5 CHLORO 3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL]BENZYL]PHOSPHONATE; DISODIUM [[2 [(3,4 DIHYDRO 5 METHYL 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL]CYCLOPENT 1 EN 1 YL](DIFLUORO)METHYL]PHOSPHONATE; DISODIUM [[2 [(3,4 DIHYDRO 5 METHYL 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL]CYCLOPENT 1 EN 1 YL]METHYL]PHOSPHONATE; DISODIUM [[2 [(5 CHLORO 3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL)METHYL]CYCLOPENT 1 EN 1 YL]METHYL]PHOSPHONATE; DISODIUM[4 (5 CHLORO 3,4 DIHYDRO 2,4 DIOXOPYRIMIDIN 1 (2H)YL)BUT 2 EN 1 YL]PHOSPHONATE; ENZYME INHIBITOR; ETHYLENE; METHYL GROUP; PHOSPHATE; PHOSPHONIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL;

EID: 66949172206     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200900003     Document Type: Article

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