Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

European Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2008, Pages 1248-1260

  Reigan, Philip ^a   Gbaj, Abdul ^a   Stratford, Ian J ^a   Bryce, Richard A ^a   Freeman, Sally ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Enzyme inhibition; Prodrug activation; Thymidine phosphorylase; Xanthine oxidase

Indexed keywords

4 CHLORO 7H PYRROLO[2,3 D]PYRIMIDINE; 5 CHLORO 6 (CHLOROMETHYL) 3H PYRIMIDIN 4 ONE; 5 CHLORO 6 [1 (2 IMINOPYRROLIDINYL)METHYL] 3H PYRIMIDIN 4 ONE; 5 CHLORO 6 METHYL 3H PYRIMIDIN 4 ONE; 6 AMINO 5 (2 ETHOXYETHENYL) 1H PYRIMIDIN 2 ONE; 6 AMINO 5 BROMO 1H PYRIMIDIN 2 ONE; 6 AMINO 5 BROMO 3H PYRIMIDIN 4 ONE; 6 AMINO 5 BROMOPYRIMIDINE; 6 AMINO 5 BROMOURACIL; 6H IMIDAZO[1,2 C]PYRIMIDIN 5 ONE; 7H PYRROLO[2,3 D]PYRIMIDIN 2(1H)ONE; 7H PYRROLO[2,3 D]PYRIMIDIN 4(3H)ONE; 7H PYRROLO[2,3 D]PYRIMIDINE; ENZYME INHIBITOR; PRODRUG; THYMIDINE PHOSPHORYLASE INHIBITOR; XANTHINE OXIDASE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; MOLECULAR MODEL;

ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PRODRUGS; SPECTROPHOTOMETRY, INFRARED; THYMIDINE PHOSPHORYLASE; XANTHINE OXIDASE;

EID: 44349105854     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.07.015     Document Type: Article

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