Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 6, 2009, Pages 567-571

  Jiang, Cheng ^a   You, Qidong ^a   Liu, Fei ^a   Wu, Wutong ^a   Guo, Qinglong ^a   Chern, Jiwang ^b   Yang, Lei ^a   Chen, Mengling ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anticancer; Kinesin spindle protein inhibitor; Pharmacophore; Tetrahydroisoquinoline

Indexed keywords

1 (3' HYDROXYPHENYL) 2 (3' CHLOROBENZOYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (4' CHLOROBENZOYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (4' HYDROXYPHENYLACETYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (4' METHOXYBENZOYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (4' METHYLBENZOYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (4' NITROPHENYLACETYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (BETA AMINOPROPIONYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 (BETA NAPHTHALIN ACETYL) 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 ACETYL 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 BUTYRYL 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 ETHOXYCARBONYL 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 METHOXYCARBONYL 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (3' HYDROXYPHENYL) 2 PHENYLACETYL 6,7 DIOXOLO 1,2,3,4 TETRAHYDROISOQUINOLINE; ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; KINESIN SPINDLE PROTEIN; MONASTROL; PROTEIN INHIBITOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CONTROL GROUP; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INHIBITION KINETICS; LIVER CELL CARCINOMA; PHARMACOPHORE;

ADENOSINE TRIPHOSPHATASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDICATORS AND REAGENTS; KINESIN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 66949149849     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.567     Document Type: Article

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