Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males

Psychoneuroendocrinology

Volumn 33, Issue 4, 2008, Pages 497-506

  Kluge, Michael ^a   Schüssler, Petra ^a   Bleninger, Philipp ^a   Kleyer, Sara ^a   Uhr, Manfred ^a   Weikel, Jutta C ^a   Yassouridis, Alexander ^a   Zuber, Verena ^a   Steiger, Axel ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Cortisol; CRH; Ghrelin; GHRH; Growth hormone; Sleep

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HYDROCORTISONE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; GROWTH HORMONE RELEASE; HORMONE ACTION; HUMAN; HYDROCORTISONE RELEASE; MALE; MONOTHERAPY; NONREM SLEEP; NORMAL HUMAN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP; SINGLE BLIND PROCEDURE; SLEEP TIME;

ADULT; CORTICOTROPIN-RELEASING HORMONE; CROSS-OVER STUDIES; DRUG THERAPY, COMBINATION; GHRELIN; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; HYDROCORTISONE; MALE; POLYSOMNOGRAPHY; REFERENCE VALUES; SINGLE-BLIND METHOD; SLEEP STAGES; WAKEFULNESS;

EID: 41849114097     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2008.01.008     Document Type: Article

References (48)

1. Banks W.A. The blood-brain barrier as a regulatory interface in the gut-brain axes. Physiol. Behav. 89 (2006) 472-476
2. Bohlhalter S., Murck H., Holsboer F., and Steiger A. Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects. Neurobiol. Aging 18 (1997) 423-429
3. Buckley T.M., and Schatzberg A.F. On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders. J. Clin. Endocrinol. Metab. 90 (2005) 3106-3114
4. Ehlers C.L., Reed T.K., and Henriksen S.J. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 42 (1986) 467-474
5. Fadda P., and Fratta W. Stress-induced sleep deprivation modifies corticotropin releasing factor (CRF) levels and CRF binding in rat brain and pituitary. Pharmacol. Res. 35 (1997) 443-446
6. Feng P., Liu X., Vurbic D., Fan H., and Wang S. Neonatal REM sleep is regulated by corticotropin releasing factor. Behav. Brain Res. 182 (2007) 95-102
7. Friess E., Tagaya H., Grethe C., Trachsel L., and Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology 29 (2004) 598-604
8. Ghigo E., Broglio F., Arvat E., Maccario M., Papotti M., and Muccioli G. Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor. Clin. Endocrinol. (Oxf) 62 (2005) 1-17
9. Hataya Y., Akamizu T., Takaya K., Kanamoto N., Ariyasu H., Saijo M., Moriyama K., Shimatsu A., Kojima M., Kangawa K., and Nakao K. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J. Clin. Endocrinol. Metab. 86 (2001) 45-52
10. Holsboer F., von Bardeleben U., and Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology 48 (1988) 32-38
11. Iranmanesh A., Carpenter P.C., Mielke K., Bowers C.Y., and Veldhuis J.D. Putative somatostatin suppression potentiates adrenocorticotropin secretion driven by ghrelin and human corticotropin-releasing hormone. J. Clin. Endocrinol. Metab. 92 (2007) 3653-3659
12. Kerkhofs M., Van Cauter E., Van Onderbergen A., Caufriez A., Thorner M.O., and Copinschi G. Sleep-promoting effects of growth hormone-releasing hormone in normal men. Am. J. Physiol. 264 (1993) E594-E598
13. Kimura M., Mueller-Preuss P., Wiesner E., Lu A., and Deussing J.M. Site-specific CRH overexpression alters sleep in transgenic mice. J. Sleep Res. 15 Suppl. 1 (2006) 101
14. Kluge M., Schüssler P., Dresler M., Yassouridis A., and Steiger A. Sleep onset REM periods in obsessive compulsive disorder. Psychiatr. Res. 152 (2007) 29-35
15. Kluge M., Schüssler P., Künzel H.E., Dresler M., Yassouridis A., and Steiger A. Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder. J. Psychiatr. Res. 41 (2007) 928-933
16. Kluge M., Schüssler P., Uhr M., Yassouridis A., and Steiger A. Ghrelin suppresses secretion of luteinizing hormone in humans. J. Clin. Endocrinol. Metab. 92 (2007) 3202-3205
17. Kluge M., Schussler P., Zuber V., Kleyer S., Yassouridis A., Dresler M., Uhr M., and Steiger A. Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep. Psychoneuroendocrinology 32 (2007) 1079-1085
18. Kluge M., Schüssler P., Zuber V., Yassouridis A., and Steiger A. Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology 32 (2007) 287-292
19. Marrosu F., Gessa G.L., Giagheddu M., and Fratta W. Corticotropin-releasing factor (CRF) increases paradoxical sleep (PS) rebound in PS-deprived rats. Brain Res. 515 (1990) 315-318
20. Marshall L., Mölle M., Boschen G., Steiger A., Fehm H.L., and Born J. Greater efficacy of episodic than continuous growth hormone-releasing hormone (GHRH) administration in promoting slow-wave sleep (SWS). J. Clin. Endocrinol. Metab. 81 (1996) 1009-1013
21. Mathias S., Held K., Ising M., Weikel J.C., Yassouridis A., and Steiger A. Systemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women. Psychoneuroendocrinology 32 (2007) 1021-1027
22. Mozid A.M., Tringali G., Forsling M.L., Hendricks M.S., Ajodha S., Edwards R., Navarra P., Grossman A.B., and Korbonits M. Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin. Horm. Metab. Res. 35 (2003) 455-459
23. Murck H., Antonijevic I.A., Frieboes R.M., Maier P., Schier T., and Steiger A. Galanin has REM-sleep deprivation-like effects on the sleep EEG in healthy young men. J. Psychiatr. Res. 33 (1999) 225-232
24. Obal Jr. F., Alfoldi P., Cady A.B., Johannsen L., Sary G., and Krueger J.M. Growth hormone-releasing factor enhances sleep in rats and rabbits. Am. J. Physiol. 255 (1988) R310-R316
25. Obal Jr. F., Alt J., Taishi P., Gardi J., and Krueger J.M. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 (2003) R131-R139
26. O'Hara B.F., Ding J., Bernat R.L., and Franken P. Genomic and proteomic approaches towards an understanding of sleep. CNS. Neurol. Disord. Drug Targets 6 (2007) 71-81
27. Opp M., Obal Jr. F., and Krueger J.M. Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits. Am. J. Physiol. 257 (1989) R528-R535
28. Peterfreund R.A., and Vale W.W. Ovine corticotropin-releasing factor stimulates somatostatin secretion from cultured brain cells. Endocrinology 112 (1983) 1275-1278
29. Raza J., Massoud A.F., Hindmarsh P.C., Robinson I.C., and Brook C.G. Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion. Clin. Endocrinol. (Oxf) 48 (1998) 217-222
30. Schier T., Guldner J., Colla M., Holsboer F., and Steiger A. Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. J. Neuroendocrinol. 9 (1997) 201-205
31. Schüssler P., Uhr M., Ising M., Weikel J.C., Schmid D.A., Held K., Mathias S., and Steiger A. Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology 31 (2006) 915-923
32. Schüssler P., Yassouridis A., Uhr M., Kluge M., Weikel J., Holsboer F., and Steiger A. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation. Am. J. Physiol. Endocrinol. Metab. 291 (2006) E549-E556
33. Staner L., Van V.C., Stefos G., Hubain P.P., Linkowski P., and Mendlewicz J. Neuroendocrine and clinical characteristics of major depressed patients exhibiting sleep-onset REM. Biol. Psychiatry 43 (1998) 817-821
34. Steiger A. Ghrelin and sleep-wake regulation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2007) R573-R574
35. Steiger A. Neurochemical regulation of sleep. J. Psychiatr. Res. 41 (2007) 537-552
36. Steiger A., Guldner J., Hemmeter U., Rothe B., Wiedemann K., and Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 56 (1992) 566-573
37. Steiger A., Guldner J., Colla-Muller M., Friess E., Sonntag A., and Schier T. Growth hormone-releasing hormone (GHRH)-induced effects on sleep EEG and nocturnal secretion of growth hormone, cortisol and ACTH in patients with major depression. J. Psychiatr. Res. 28 (1994) 225-238
38. Szentirmai E., Hajdu I., Obal Jr. F., and Krueger J.M. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res. 1088 (2006) 131-140
39. Szentirmai E., Kapas L., and Krueger J.M. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 (2007) R575-R585
40. Szentirmai E., Kapas L., Sun Y., Smith R.G., and Krueger J.M. Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R510-R517
41. Takaya K., Ariyasu H., Kanamoto N., Iwakura H., Yoshimoto A., Harada M., Mori K., Komatsu Y., Usui T., Shimatsu A., Ogawa Y., Hosoda K., Akamizu T., Kojima M., Kangawa K., and Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J. Clin. Endocrinol. Metab. 85 (2000) 4908-4911
42. Tolle V., Bassant M.H., Zizzari P., Poindessous-Jazat F., Tomasetto C., Epelbaum J., and Bluet-Pajot M.T. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143 (2002) 1353-1361
43. Treuer T. The potential role of ghrelin in the mechanism of sleep deprivation therapy for depression. Sleep Med. Rev. 11 (2007) 523-524
44. Tsuno N., Besset A., and Ritchie K. Sleep and depression. J. Clin. Psychiatry 66 (2005) 1254-1269
45. Veldhuis J.D., Iranmanesh A., Mielke K., Miles J.M., Carpenter P.C., and Bowers C.Y. Ghrelin potentiates growth hormone secretion driven by putative somatostatin withdrawal and resists inhibition by human corticotropin-releasing hormone. J. Clin. Endocrinol. Metab. 91 (2006) 2441-2446
46. Vgontzas A.N., Bixler E.O., Wittman A.M., Zachman K., Lin H.M., Vela-Bueno A., Kales A., and Chrousos G.P. Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications. J. Clin. Endocrinol. Metab. 86 (2001) 1489-1495
47. Weikel J.C., Wichniak A., Ising M., Brunner H., Friess E., Held K., Mathias S., Schmid D.A., Uhr M., and Steiger A. Ghrelin promotes slow-wave sleep in humans. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E407-E415
48. Wyatt J.K., Dijk D.J., Ritz-de C.A., Ronda J.M., and Czeisler C.A. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep 29 (2006) 609-618