Type 2 iodothyronine deiodinase in skeletal muscle: Effects of hypothyroidism and fasting

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 6, 2009, Pages 2144-2150

  Heemstra, Karen A ^a   Soeters, Maarten R ^b   Fliers, Eric ^b   Serlie, Mireille J ^b   Burggraaf, Jacobus ^c   Van Doorn, Martijn B ^c   Van Der Klaauw, Agatha A ^a   Romijn, Johannes A ^a   Smit, Johannes W ^a   Corssmit, Eleonora P ^a   Visser, Theo J ^d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; IODOTHYRONINE DEIODINASE D2; LIOTHYRONINE; MESSENGER RNA; RADIOACTIVE IODINE; THYROTROPIN; THYROXINE; THYROXINE DEIODINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; DIET RESTRICTION; ENZYME ACTIVITY; FEMALE; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HYPERINSULINEMIA; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RNA ISOLATION; SKELETAL MUSCLE; THYROID CARCINOMA; THYROIDECTOMY; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; UNIVERSITY HOSPITAL; VASTUS LATERALIS MUSCLE;

EID: 66749101298     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-2520     Document Type: Article

References (45)

1. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR 2002 Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89 (Pubitemid 34185306)
2. Bianco AC, Kim BW 2006 Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest 116:2571-2579 (Pubitemid 44511617)
3. Köhrle J 1999 Local activation and inactivation of thyroid hormones: the deiodinase family. Mol Cell Endocrinol 151:103-119 (Pubitemid 29278820)
4. Geffner DL, Azukizawa M, Hershman JM 1975 Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man. J Clin Invest 55:224-229
5. Saberi M, Sterling FH, Utiger RD 1975 Reduction in extrathyroidal triiodothyronine production by propylthiouracil in man. J Clin Invest 55:218-223
6. Croteau W, Davey JC, Galton VA, St Germain DL 1996 Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest 98:405-417 (Pubitemid 26255740)
7. Maeda A, Toyoda N, Yasuzawa-Amano S, Iwasaka T, Nishikawa M 2003 Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells. Mol Cell Endocrinol 200:111-117 (Pubitemid 36331919)
8. Mizuma H, Murakami M, Mori M 2001 Thyroid hormone activation in human vascular smooth muscle cells: expression of type II iodothyronine deiodinase. Circ Res 88:313-318 (Pubitemid 32173755)
9. Salvatore D, Bartha T, Harney JW, Larsen PR 1996 Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology 137:3308-3315 (Pubitemid 26250180)
10. Salvatore D, Tu H, Harney JW, Larsen PR 1996 Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 98:962-968 (Pubitemid 26293314)
11. Inada M, Kasagi K, Kurata S, Kazama Y, Takayama H, Torizuka K, Fukase M, Soma T 1975 Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man. J Clin Invest 55:1337-1348 (Pubitemid 8036496)
12. Lum SM, Nicoloff JT, Spencer CA, Kaptein EM 1984 Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man. J Clin Invest 73:570-575 (Pubitemid 14194639)
13. Mebis L, Langouche L, Visser TJ, Van den Berghe G 2007 The type II iodothyronine deiodinase is up-regulated in skeletal muscle during prolonged critical illness. J Clin Endocrinol Metab 92:3330-3333 (Pubitemid 47236410)
14. Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR 2005 Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest 115:2524-2533 (Pubitemid 41266215)
15. Portnay GI, O'Brian JT, Bush J, Vagenakis AG, Azizi F, Arky RA, Ingbar SH, Braverman LE 1974 The effect of starvation on the concentration and binding of thyroxine and triiodothyronine in serum and on the response to TRH. J Clin Endocrinol Metab 39:191-194
16. Vignati L, Finley RJ, Hagg S, Aoki TT 1978 Protein conservation during prolonged fast: a function of triiodothyronine levels. Trans Assoc Am Physicians 91:169-179 (Pubitemid 9176857)
17. Merimee TJ, Fineberg ES 1976 Starvation-induced alterations of circulating thyroid hormone concentrations in man. Metabolism 25:79-83
18. Vagenakis AG, Portnay GI, O'Brian JT, Rudolph M, Arky RA, Ingbar SH, Braverman LE 1977 Effect of starvation on the production and metabolism of thyroxine and triiodothyronine in euthyroid obese patients. J Clin Endocrinol Metab 45:1305-1309 (Pubitemid 8253459)
19. Martinez-deMena R, Obregón MJ 2005 Insulin increases the adrenergic stimulation of 5′ deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K. J Mol Endocrinol 34:139-151 (Pubitemid 40305556)
20. Mills I, Barge RM, Silva JE, Larsen PR 1987 Insulin stimulation of iodothyronine 5′-deiodinase in rat brown adipocytes. Biochem Biophys Res Commun 143:81-86 (Pubitemid 17030467)
21. Silva JE, Larsen PR 1986 Hormonal regulation of iodothyronine 5′-deiodinase in rat brown adipose tissue. Am J Physiol 251:E639-E643 (Pubitemid 17212606)
22. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW 26 November 2009 Type 2 deiodinase expression is induced by PPAR-γ agonists in skeletal myocytes. Endocrinology 150:1976-1983
23. Soeters MR, Sauerwein HP, Dubbelhuis PF, Groener JE, Ackermans MT, Fliers E, Aerts JM, Serlie MJ 2008 Muscle adaptation to short-term fasting in healthy lean humans. J Clin Endocrinol Metab 93:2900-2903
24. Heemstra KA, van der Deure WM, Peeters RP, Hamdy NA, Stokkel MP, Corssmit EP, Romijn JA, Visser TJ, Smit JW 2008 Thyroid hormone independent associations between serum TSH levels and indicators of bone turnover in cured patients with differentiated thyroid carcinoma. Eur J Endocrinol 159:69-76
25. Langeveld M, Endert E, Wiersinga WM, Aerts JM, Hollak CE 2007 Hypermetabolism in Gaucher disease type I is not associated with altered thyroid hormone levels. J Inherit Metab Dis 30:985
26. Richard K, Hume R, Kaptein E, Sanders JP, van Toor H, De Herder WW, den Hollander JC, Krenning EP, Visser TJ 1998 Ontogeny of iodothyronine deiodinases in human liver. J Clin Endocrinol Metab 83:2868-2874 (Pubitemid 28493790)
27. Kuiper GG, Klootwijk W, Visser TJ 2002 Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor. Endocrinology 143:1190-1198 (Pubitemid 34274346)
28. Silva JE, Larsen PR 1982 Comparison of iodothyronine 5′-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism. J Clin Invest 70:1110-1123 (Pubitemid 13254935)
29. St Germain DL 1985 Metabolic effect of 3,3′,5′- triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. Evidence for a unique mechanism of thyroid hormone action. J Clin Invest 76:890-893 (Pubitemid 15023150)
30. St Germain DL 1988 The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5′-deiodinase. Endocrinology 122:1860-1868 (Pubitemid 18128622)
31. Burmeister LA, Pachucki J, St Germain DL 1997 Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms. Endocrinology 138:5231-5237 (Pubitemid 27509683)
32. Kaplan MM, Yaskoski KA 1981 Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum, and hypothalamus. J Clin Invest 67:1208-1214 (Pubitemid 11090563)
33. Peeters RP, Wouters PJ, Kaptein E, van Toor H, Visser TJ, Van den Berghe G 2003 Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. J Clin Endocrinol Metab 88:3202-3211 (Pubitemid 36877495)
34. Silva JE, Gordon MB, Crantz FR, Leonard JL, Larsen PR 1984 Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest 73:898-907 (Pubitemid 14132817)
35. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL 2005 The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 90:3472-3478 (Pubitemid 41014316)
36. Cheron RG, Kaplan MM, Larsen PR 1979 Physiological and pharmacological influences on thyroxine to 3,5,3′-triiodothyronine conversion and nuclear 3,5,3′-triiodothyronine binding in rat anterior pituitary. J Clin Invest 64:1402-1414
37. Leonard JL, Kaplan MM, Visser TJ, Silva JE, Larsen PR 1981 Cerebral cortex responds rapidly to thyroid hormones. Science 214:571-573 (Pubitemid 12206157)
38. Visser TJ, Leonard JL, Kaplan MM, Larsen PR 1982 Kinetic evidence suggesting two mechanisms for iodothyronine 5′-deiodination in rat cerebral cortex. Proc Natl Acad Sci USA 79:5080-5084
39. Kaplan MM, Yaskoski KA 1980 Phenolic and tyrosyl ring deiodination of iodothyronines in rat brain homogenates. J Clin Invest 66:551-562 (Pubitemid 10053920)
40. Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS 2003 The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 111:1409-1421 (Pubitemid 36554712)
41. Boelen A, Kwakkel J, Vos XG, Wiersinga WM, Fliers E 2006 Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor β2 mRNA expression in mice. J Endocrinol 190:537-544 (Pubitemid 44307819)
42. Lisboa PC, Cabanelas AP, Curty FH, Oliveira KJ, Ortiga-Carvalho TM, Moura EG, Nascimento-Saba CC, Rosenthal D, Pazos-Moura CC 2007 Modulation of type 2 iodothyronine deiodinase activity in rat thyroid gland. Horm Metab Res 39:538-541 (Pubitemid 47204201)
43. O'Mara BA, Dittrich W, Lauterio TJ, St Germain DL 1993 Pretranslational regulation of type I 5′-deiodinase by thyroid hormones and in fasted and diabetic rats. Endocrinology 133:1715-1723 (Pubitemid 23295200)
44. Diano S, Naftolin F, Goglia F, Horvath TL 1998 Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. Endocrinology 139:2879-2884 (Pubitemid 28512399)
45. Huang SA, Bianco AC 2008 Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab 4:148-155