-
1
-
-
0026443183
-
Pancytopenia related to azathioprine - an enzyme deficiency caused by a common genetic polymorphism: A review
-
Anstey A et al. Pancytopenia related to azathioprine - an enzyme deficiency caused by a common genetic polymorphism: a review. J Royal Soc Med 1992; 85: 752-6.
-
(1992)
J Royal Soc Med
, vol.85
, pp. 752-756
-
-
Anstey, A.1
-
2
-
-
0036312490
-
Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK
-
Holme SA et al. Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK. Q J Med 2002; 95: 439-44.
-
(2002)
Q J Med
, vol.95
, pp. 439-444
-
-
Holme, S.A.1
-
3
-
-
42449125302
-
Ethnic variation of thiopurine S-methyltransferase activity: A large, prospective population study
-
Cooper SC et al. Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study. Pharmacogenomics 2008; 9: 303-9.
-
(2008)
Pharmacogenomics
, vol.9
, pp. 303-309
-
-
Cooper, S.C.1
-
4
-
-
11144340253
-
Guidelines for prescribing azathioprine in dermatology
-
Anstey AV et al. Guidelines for prescribing azathioprine in dermatology. Br J Dermatol 2004; 151: 1123-32.
-
(2004)
Br J Dermatol
, vol.151
, pp. 1123-1132
-
-
Anstey, A.V.1
-
5
-
-
33746866362
-
Azathioprine in dermatology: The past, the present, and the future
-
Patel AA et al. Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol 2006; 55: 369-89.
-
(2006)
J Am Acad Dermatol
, vol.55
, pp. 369-389
-
-
Patel, A.A.1
-
6
-
-
77749291050
-
-
Summary of product characteristics. GlaxoSmithKline UK. June, UK
-
Imuran Tablets 25mg. Summary of product characteristics. GlaxoSmithKline UK. June 2007, UK.
-
(2007)
Imuran Tablets 25mg
-
-
-
7
-
-
50649110056
-
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: A review
-
Gisbert JP, Gomollon F. Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. Am J Gastroenterol 2008; 103: 1783-800.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 1783-1800
-
-
Gisbert, J.P.1
Gomollon, F.2
-
8
-
-
25844453682
-
-
Joint Formulary Committee, Edition 56. London: Royal Pharmaceutical Society of Great Britain and British Medical Association, September
-
Joint Formulary Committee. British National Formulary. Edition 56. London: Royal Pharmaceutical Society of Great Britain and British Medical Association, September 2008.
-
(2008)
British National Formulary
-
-
-
9
-
-
4344602852
-
Guidelines for the management of inflammatory bowel disease in adults
-
Carter MJ et al. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53 (suppl V) V1-16.
-
(2004)
Gut
, vol.53
, Issue.SUPPL. V
-
-
Carter, M.J.1
-
10
-
-
33845415085
-
Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: Long-term follow-up study of 394 patients
-
Gisbert JP et al. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Am J Gastronterol 2006; 101: 2769-76.
-
(2006)
Am J Gastronterol
, vol.101
, pp. 2769-2776
-
-
Gisbert, J.P.1
-
11
-
-
0031715622
-
Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis
-
Stolk JN et al. Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis. Arth Rheum 1998 41: 1858-66.
-
(1998)
Arth Rheum
, vol.41
, pp. 1858-1866
-
-
Stolk, J.N.1
-
12
-
-
0034093057
-
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
-
Colombel JF et al. Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy. Gastroenterology 2000; 118: 1025-30.
-
(2000)
Gastroenterology
, vol.118
, pp. 1025-1030
-
-
Colombel, J.F.1
-
13
-
-
0035871560
-
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
-
Evans WE et al. Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001; 19: 2293-301.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2293-2301
-
-
Evans, W.E.1
-
14
-
-
0032732591
-
Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine
-
Naughton MA et al. Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine. Rheumatology 1999; 38: 640-44.
-
(1999)
Rheumatology
, vol.38
, pp. 640-644
-
-
Naughton, M.A.1
-
15
-
-
52149099443
-
Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease
-
Ansari A et al. Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2008; 28: 973-83.
-
(2008)
Aliment Pharmacol Ther
, vol.28
, pp. 973-983
-
-
Ansari, A.1
-
16
-
-
0000514590
-
Thiopurine methyltransferase pharmacogenetics: Human liver enzyme activity
-
Szumlanski CL et al. Thiopurine methyltransferase pharmacogenetics: human liver enzyme activity. Clin Pharmacol Ther 1988; 43: 134.
-
(1988)
Clin Pharmacol Ther
, vol.43
, pp. 134
-
-
Szumlanski, C.L.1
-
17
-
-
0026907122
-
Human liver thiopurine methyltransferase pharmacogenetics: Biochemical properties, liver-erythrocyte correlation and presence of isozymes
-
Szumlanski CL et al. Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992; 2: 148-59.
-
(1992)
Pharmacogenetics
, vol.2
, pp. 148-159
-
-
Szumlanski, C.L.1
-
18
-
-
9644272507
-
Whose TPMT is it anyway?
-
Ford L et al. Whose TPMT is it anyway? Ann Clin Biochem 2004; 41: 498-500.
-
(2004)
Ann Clin Biochem
, vol.41
, pp. 498-500
-
-
Ford, L.1
-
19
-
-
77749238508
-
Dudley Road, Birmingham 2008
-
Pathology Department, City Hospital, online, Available:, Accessed 22 December
-
Pathology Department, City Hospital, Dudley Road, Birmingham 2008. Tests: thiopurine methyltransferase service [online]. Available: http://www.cityassays.org.uk/tpmt.html [Accessed 22 December 2008].
-
(2008)
Tests: Thiopurine methyltransferase service
-
-
-
20
-
-
33947357078
-
Current use of pharmacogenetic testing: A national survey of thiopurine methyltransferase testing prior to azathioprine prescription
-
Fargher EA et al. Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription. J Clin Pharm Ther 2007; 32: 187-95.
-
(2007)
J Clin Pharm Ther
, vol.32
, pp. 187-195
-
-
Fargher, E.A.1
-
21
-
-
0032212759
-
Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine
-
Black AJ et al. Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine. Ann Intern Med 1998; 129: 716-8.
-
(1998)
Ann Intern Med
, vol.129
, pp. 716-718
-
-
Black, A.J.1
-
22
-
-
77749232637
-
A prospective randomised controlled trial of azathioprine methyltransferase (TPMT) genotyping in the management of patients, prior to commencement of azathioprine
-
online, Available:, Accessed 22 December 2008
-
Ollier WER. A prospective randomised controlled trial of azathioprine methyltransferase (TPMT) genotyping in the management of patients, prior to commencement of azathioprine. UK Clnical Trials Gateway (Trial completed) [online]. Available: http://www.controlled-trials.com/mrct/trial/238433/ azathioprine [Accessed 22 December 2008].
-
UK Clnical Trials Gateway (Trial completed)
-
-
Ollier, W.E.R.1
-
23
-
-
33644837550
-
Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe-atopic eczema: A double-blind randomised controlled trial
-
Meggitt SJ et al. Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe-atopic eczema: a double-blind randomised controlled trial. Lancet 2006; 367: 839-46.
-
(2006)
Lancet
, vol.367
, pp. 839-846
-
-
Meggitt, S.J.1
-
24
-
-
44749084416
-
Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold
-
Gardiner SJ et al. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol 2008; 6: 654-60.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 654-660
-
-
Gardiner, S.J.1
-
25
-
-
33745460088
-
Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study
-
Gisbert JP. Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study. Hepatogastroenterology 2006; 53: 399-404.
-
(2006)
Hepatogastroenterology
, vol.53
, pp. 399-404
-
-
Gisbert, J.P.1
-
26
-
-
46749126229
-
Avoiding adverse drug reactions by pharmacogenetic testing: A systematic review of the economic evidence in the case of TPMT and AZA-induced side effects
-
Compagni A et al. Avoiding adverse drug reactions by pharmacogenetic testing: a systematic review of the economic evidence in the case of TPMT and AZA-induced side effects. Int J Technol Assess Health Care 2008; 24: 294-302.
-
(2008)
Int J Technol Assess Health Care
, vol.24
, pp. 294-302
-
-
Compagni, A.1
-
27
-
-
56149097636
-
Removing barriers to a clinical pharmacogenetics service
-
Newman W, Payne K. Removing barriers to a clinical pharmacogenetics service. Personalized Med 2008; 5: 471-80.
-
(2008)
Personalized Med
, vol.5
, pp. 471-480
-
-
Newman, W.1
Payne, K.2
-
28
-
-
14144253110
-
The management of myasthenia gravis
-
Hilton-Jones D, Palace, J. The management of myasthenia gravis. Pract Neurol 2005; 5: 18-27.
-
(2005)
Pract Neurol
, vol.5
, pp. 18-27
-
-
Hilton-Jones, D.1
Palace, J.2
-
29
-
-
38749095183
-
European evidence-based consensus on the management of ulcerative colitis: Current management
-
Travis SPL et al. European evidence-based consensus on the management of ulcerative colitis: current management. J Crohn's and Colitis 2008; 2: 24-62.
-
(2008)
J Crohn's and Colitis
, vol.2
, pp. 24-62
-
-
Travis, S.P.L.1
|