메뉴 건너뛰기




Volumn 413, Issue 2, 1998, Pages 191-203

Genotoxic activity of four inhibitors of DNA topoisomerases in larval cells of Drosophila melanogaster as measured in the wing spot assay

Author keywords

Drosophila; Genotoxicity; Mitotic recombination; Somatic mutation; Topoisomerase inhibitor

Indexed keywords

AMSACRINE; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; MESYLIC ACID ETHYL ESTER; NALIDIXIC ACID;

EID: 0032536708     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00031-X     Document Type: Article
Times cited : (27)

References (51)
  • 1
    • 0013995768 scopus 로고
    • Mitotic recombination induced in Saccharomyces cerevisiae with nitrous acid, diethylsulfate and carcinogenic, alkylating nitrosamides
    • Zimmermann F.K., Schwaier R., Laer U.V. Mitotic recombination induced in Saccharomyces cerevisiae with nitrous acid, diethylsulfate and carcinogenic, alkylating nitrosamides. Z. Vererbungsl. 98:1966;230-246.
    • (1966) Z. Vererbungsl , vol.98 , pp. 230-246
    • Zimmermann, F.K.1    Schwaier, R.2    Laer, U.V.3
  • 2
    • 0024806118 scopus 로고
    • The importance of mitotic recombination in genetic toxicology
    • Würgler F.E. The importance of mitotic recombination in genetic toxicology. Rev. Toxicol. 6:1989;131-137.
    • (1989) Rev. Toxicol. , vol.6 , pp. 131-137
    • Würgler, F.E.1
  • 3
    • 0026475266 scopus 로고
    • Hereditary conditions in which the loss of heterozygosity may be important
    • Müller H., Scott R. Hereditary conditions in which the loss of heterozygosity may be important. Mutat. Res. 284:1992;15-24.
    • (1992) Mutat. Res. , vol.284 , pp. 15-24
    • Müller, H.1    Scott, R.2
  • 4
    • 0026495022 scopus 로고
    • Recombination and gene conversion
    • Würgler F.E. Recombination and gene conversion. Mutat. Res. 284:1992;3-14.
    • (1992) Mutat. Res. , vol.284 , pp. 3-14
    • Würgler, F.E.1
  • 5
    • 0028294503 scopus 로고
    • Induction of genetic recombination: Consequences and model systems
    • Hoffmann G.R. Induction of genetic recombination: Consequences and model systems. Environ. Mol. Mutagen. 23:1994;59-66.
    • (1994) Environ. Mol. Mutagen. , vol.23 , pp. 59-66
    • Hoffmann, G.R.1
  • 6
    • 0022607863 scopus 로고
    • In vivo mutagenicity testing using somatic cells of Drosophila melanogaster
    • in: F.J. De Serres (Ed.) Plenum, New York
    • F.E. Würgler, E.W. Vogel, In vivo mutagenicity testing using somatic cells of Drosophila melanogaster, in: F.J. De Serres (Ed.), Chemical Mutagens, Principles and Methods for their Detection, Plenum, New York, 1986, pp. 1-72.
    • (1986) Chemical Mutagens, Principles and Methods for Their Detection , pp. 1-72
    • Würgler, F.E.1    Vogel, E.W.2
  • 7
    • 0026485087 scopus 로고
    • Bacterial assays for recombinagens
    • Hoffmann G.R. Bacterial assays for recombinagens. Mutat. Res. 284:1992;125-146.
    • (1992) Mutat. Res. , vol.284 , pp. 125-146
    • Hoffmann, G.R.1
  • 8
    • 0028077919 scopus 로고
    • The role of mitotic recombination in carcinogenesis
    • Sengstag C. The role of mitotic recombination in carcinogenesis. Crit. Rev. Toxicol. 24:1994;323-353.
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. 323-353
    • Sengstag, C.1
  • 9
    • 0022580055 scopus 로고
    • Recessive mutant genes predisposing to human cancer
    • Cavenee W.T., Koufos A., Hansen M.F. Recessive mutant genes predisposing to human cancer. Mutat. Res. 168:1986;3-14.
    • (1986) Mutat. Res. , vol.168 , pp. 3-14
    • Cavenee, W.T.1    Koufos, A.2    Hansen, M.F.3
  • 10
    • 0023940754 scopus 로고
    • Short-term testing - Are we looking at wrong endpoints?
    • Ramel C. Short-term testing - are we looking at wrong endpoints? Mutat. Res. 205:1988;13-24.
    • (1988) Mutat. Res. , vol.205 , pp. 13-24
    • Ramel, C.1
  • 11
    • 0026059515 scopus 로고
    • Tumor suppressor genes
    • Marshall C.J. Tumor suppressor genes. Cell. 64:1991;313-326.
    • (1991) Cell , vol.64 , pp. 313-326
    • Marshall, C.J.1
  • 12
    • 0029930281 scopus 로고    scopus 로고
    • The somatic white-ivory eye spot test does not detect the same spectrum of genotoxic events as the wing somatic mutation and recombination test in Drosophila melanogaster
    • Graf U., Würgler F.E. The somatic white-ivory eye spot test does not detect the same spectrum of genotoxic events as the wing somatic mutation and recombination test in Drosophila melanogaster. Environ. Mol. Mutagen. 27:1996;219-226.
    • (1996) Environ. Mol. Mutagen. , vol.27 , pp. 219-226
    • Graf, U.1    Würgler, F.E.2
  • 13
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu L.F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58:1989;351-375.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 14
    • 0024592815 scopus 로고
    • Biochemical basis for the interactions of type I and type II topoisomerases with DNA
    • Osheroff N. Biochemical basis for the interactions of type I and type II topoisomerases with DNA. Pharmacol. Ther. 41:1989;223-241.
    • (1989) Pharmacol. Ther. , vol.41 , pp. 223-241
    • Osheroff, N.1
  • 15
    • 0024997668 scopus 로고
    • The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?
    • Wang J.C., Caron P.R., Kim R.A. The role of DNA topoisomerases in recombination and genome stability: a double-edged sword? Cell. 62:1990;403-406.
    • (1990) Cell , vol.62 , pp. 403-406
    • Wang, J.C.1    Caron, P.R.2    Kim, R.A.3
  • 16
    • 0028122271 scopus 로고
    • Mutagenicity and carcinogenicity of topoisomerase-interactive drugs
    • Anderson R.D., Berger N.A. Mutagenicity and carcinogenicity of topoisomerase-interactive drugs. Mutat. Res. 309:1994;109-142.
    • (1994) Mutat. Res. , vol.309 , pp. 109-142
    • Anderson, R.D.1    Berger, N.A.2
  • 18
    • 0024600578 scopus 로고
    • Thirty compounds tested in the Drosophila wing spot test
    • Graf U., Frei H., Kägi A., Katz A.J., Würgler F.E. Thirty compounds tested in the Drosophila wing spot test. Mutat. Res. 222:1989;359-373.
    • (1989) Mutat. Res. , vol.222 , pp. 359-373
    • Graf, U.1    Frei, H.2    Kägi, A.3    Katz, A.J.4    Würgler, F.E.5
  • 19
    • 0023751542 scopus 로고
    • Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result
    • Frei H., Würgler F.E. Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result. Mutat. Res. 203:1988;297-308.
    • (1988) Mutat. Res. , vol.203 , pp. 297-308
    • Frei, H.1    Würgler, F.E.2
  • 20
    • 0026503556 scopus 로고
    • The genotoxicity of the anti-cancer drug mitoxantrone in somatic and germ cells of Drosophila melanogaster
    • Frei H., Clements J., Howe D., Würgler F.E. The genotoxicity of the anti-cancer drug mitoxantrone in somatic and germ cells of Drosophila melanogaster. Mutat. Res. 279:1992;21-33.
    • (1992) Mutat. Res. , vol.279 , pp. 21-33
    • Frei, H.1    Clements, J.2    Howe, D.3    Würgler, F.E.4
  • 21
    • 0014788551 scopus 로고
    • Tables for determining the statistical significance of mutation frequencies
    • Kastenbaum M.A., Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 9:1970;527-549.
    • (1970) Mutat. Res. , vol.9 , pp. 527-549
    • Kastenbaum, M.A.1    Bowman, K.O.2
  • 22
    • 0024559290 scopus 로고
    • Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test
    • Alonso Moraga A., Graf U. Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test. Mutagenesis. 4:1989;105-110.
    • (1989) Mutagenesis , vol.4 , pp. 105-110
    • Alonso Moraga, A.1    Graf, U.2
  • 23
    • 0026694290 scopus 로고
    • Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures
    • Schlesinger R.B., Zelikoff J.T., Chen L.C., Kinney P.L. Assessment of toxicologic interactions resulting from acute inhalation exposure to sulfuric acid and ozone mixtures. Toxicol. Appl. Pharmacol. 115:1992;183-190.
    • (1992) Toxicol. Appl. Pharmacol. , vol.115 , pp. 183-190
    • Schlesinger, R.B.1    Zelikoff, J.T.2    Chen, L.C.3    Kinney, P.L.4
  • 24
    • 0030033147 scopus 로고    scopus 로고
    • Interaction of nickel with mutagens in the induction of sister chromatid exchanges in human lymphocytes
    • Katsifis S.P., Kinney P.L., Hosselet S., Burns F.J., Christie N.T. Interaction of nickel with mutagens in the induction of sister chromatid exchanges in human lymphocytes. Mutat. Res. 359:1996;7-15.
    • (1996) Mutat. Res. , vol.359 , pp. 7-15
    • Katsifis, S.P.1    Kinney, P.L.2    Hosselet, S.3    Burns, F.J.4    Christie, N.T.5
  • 25
    • 0024990610 scopus 로고
    • Genetic toxicology of six carcinogens and six non-carcinogens in the Drosophila wing spot test
    • Tripathy N.K., Würgler F.E., Frei A. Genetic toxicology of six carcinogens and six non-carcinogens in the Drosophila wing spot test. Mutat. Res. 242:1990;169-180.
    • (1990) Mutat. Res. , vol.242 , pp. 169-180
    • Tripathy, N.K.1    Würgler, F.E.2    Frei, A.3
  • 27
    • 0028925446 scopus 로고
    • Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila
    • Frei H., Würgler F.E. Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila. Mutat. Res. 334:1995;247-258.
    • (1995) Mutat. Res. , vol.334 , pp. 247-258
    • Frei, H.1    Würgler, F.E.2
  • 28
    • 0030037728 scopus 로고    scopus 로고
    • Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster
    • Frei H., Würgler F.E. Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster. Mutagenesis. 11:1996;315-325.
    • (1996) Mutagenesis , vol.11 , pp. 315-325
    • Frei, H.1    Würgler, F.E.2
  • 29
    • 0024278459 scopus 로고
    • Inhibitors of DNA topoisomerases
    • Drlica F., Franco R. Inhibitors of DNA topoisomerases. Biochemistry. 27:1988;2253-2259.
    • (1988) Biochemistry , vol.27 , pp. 2253-2259
    • Drlica, F.1    Franco, R.2
  • 30
    • 0025058237 scopus 로고
    • Killing and mutation induced in quiescent V79 cells as influenced by nalidixic acid
    • Ghosh R., Bhattacharjee S.B. Killing and mutation induced in quiescent V79 cells as influenced by nalidixic acid. Mutat. Res. 243:1990;7-12.
    • (1990) Mutat. Res. , vol.243 , pp. 7-12
    • Ghosh, R.1    Bhattacharjee, S.B.2
  • 31
    • 0026806859 scopus 로고
    • Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis
    • Summer A.T. Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis. J. Cell Sci. 103:1992;105-115.
    • (1992) J. Cell Sci. , vol.103 , pp. 105-115
    • Summer, A.T.1
  • 32
    • 0019189329 scopus 로고
    • Sister chromatid exchanges in children treated with nalidixic acid
    • Kowalezyk J. Sister chromatid exchanges in children treated with nalidixic acid. Mutat. Res. 77:1980;371-375.
    • (1980) Mutat. Res. , vol.77 , pp. 371-375
    • Kowalezyk, J.1
  • 33
    • 0030570559 scopus 로고    scopus 로고
    • Sister-chromatid exchanges (SCE) induction by inhibitors of DNA topoisomerases in cultured human lymphocytes
    • Ribas G., Xamena N., Creus A., Marcos R. Sister-chromatid exchanges (SCE) induction by inhibitors of DNA topoisomerases in cultured human lymphocytes. Mutat. Res. 368:1996;205-211.
    • (1996) Mutat. Res. , vol.368 , pp. 205-211
    • Ribas, G.1    Xamena, N.2    Creus, A.3    Marcos, R.4
  • 34
    • 0026519925 scopus 로고
    • Modulation of genotoxicity in Drosophila
    • Ramel C., Magnusson J. Modulation of genotoxicity in Drosophila. Mutat. Res. 267:1992;221-227.
    • (1992) Mutat. Res. , vol.267 , pp. 221-227
    • Ramel, C.1    Magnusson, J.2
  • 35
    • 0019376425 scopus 로고
    • DNA topoisomerases
    • Gellert M. DNA topoisomerases. Annu. Rev. Biochem. 50:1981;879-910.
    • (1981) Annu. Rev. Biochem. , vol.50 , pp. 879-910
    • Gellert, M.1
  • 36
    • 0024507201 scopus 로고
    • The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II: I. m-AMSA
    • Andersson H.C., Kihlman B.A. The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II: I. m-AMSA. Carcinogenesis. 10:1989;123-130.
    • (1989) Carcinogenesis , vol.10 , pp. 123-130
    • Andersson, H.C.1    Kihlman, B.A.2
  • 37
    • 0021792433 scopus 로고
    • Correlations between intercalator-induced DNA strand breaks and sister-chromatid exchanges, mutations and cytotoxicity in Chinese hamster cells
    • Pommier Y., Zwelling L.A., Shan C.K., Whang-Peng J., Bradley M.O. Correlations between intercalator-induced DNA strand breaks and sister-chromatid exchanges, mutations and cytotoxicity in Chinese hamster cells. Cancer Res. 45:1985;3143-3149.
    • (1985) Cancer Res. , vol.45 , pp. 3143-3149
    • Pommier, Y.1    Zwelling, L.A.2    Shan, C.K.3    Whang-Peng, J.4    Bradley, M.O.5
  • 38
    • 0024574046 scopus 로고
    • Micronucleus, chromosome aberrations, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells
    • Doerr C.L., Harrington-Brock K., Moore M.M. Micronucleus, chromosome aberrations, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells. Mutat. Res. 222:1989;191-203.
    • (1989) Mutat. Res. , vol.222 , pp. 191-203
    • Doerr, C.L.1    Harrington-Brock, K.2    Moore, M.M.3
  • 40
  • 44
    • 0027465298 scopus 로고
    • Evaluation of genotoxicity of the indenoisoquinoline analogues of fagaronine and nitidine in Drosophila melanogaster
    • Pérez-Chiesa Y., Narvaez Z. Evaluation of genotoxicity of the indenoisoquinoline analogues of fagaronine and nitidine in Drosophila melanogaster. Mutat. Res. 301:1993;207-212.
    • (1993) Mutat. Res. , vol.301 , pp. 207-212
    • Pérez-Chiesa, Y.1    Narvaez, Z.2
  • 45
    • 0028068128 scopus 로고
    • Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells
    • Cortés F., Piñero J. Synergistic effect of inhibitors of topoisomerase I and II on chromosome damage and cell killing in cultured Chinese hamster ovary cells. Cancer Chemother. Pharmacol. 34:1994;411-415.
    • (1994) Cancer Chemother. Pharmacol. , vol.34 , pp. 411-415
    • Cortés, F.1    Piñero, J.2
  • 46
    • 0028014665 scopus 로고
    • Preferential pericentric lesions and aneuploidy induced in mouse oocytes by the topoisomerase II inhibitor etoposide
    • Mailhes J.B., Marchetti F., Phillips G.L. Jr., Barnhill D.R. Preferential pericentric lesions and aneuploidy induced in mouse oocytes by the topoisomerase II inhibitor etoposide. Teratogen. Carcinogen. Mutagen. 14:1994;39-51.
    • (1994) Teratogen. Carcinogen. Mutagen. , vol.14 , pp. 39-51
    • Mailhes, J.B.1    Marchetti, F.2    Phillips G.L., Jr.3    Barnhill, D.R.4
  • 47
    • 0023958908 scopus 로고
    • Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes
    • Zhang H., Wang J.C., Liu L.F. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc. Natl. Acad. Sci. U.S.A. 85:1988;1060-1064.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 1060-1064
    • Zhang, H.1    Wang, J.C.2    Liu, L.F.3
  • 48
    • 0024431084 scopus 로고
    • Interaction of topoisomerase I with the transcribed region of the Drosophila HSP 70 heat shock gene
    • Kroeger P.E., Rowe T.C. Interaction of topoisomerase I with the transcribed region of the Drosophila HSP 70 heat shock gene. Nucleic Acids Res. 17:1989;8495-8509.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 8495-8509
    • Kroeger, P.E.1    Rowe, T.C.2
  • 49
    • 0024512460 scopus 로고
    • The level of Z-DNA in metabolically active permeabilized mammalian cell nuclei is regulated by torsional strain
    • Wittig B., Dorbic T., Rich A. The level of Z-DNA in metabolically active permeabilized mammalian cell nuclei is regulated by torsional strain. J. Cell Biol. 108:1989;755-764.
    • (1989) J. Cell Biol. , vol.108 , pp. 755-764
    • Wittig, B.1    Dorbic, T.2    Rich, A.3
  • 50
    • 0005566316 scopus 로고
    • Dose-response analysis of data obtained in the Drosophila wing spot test after ethyl methanesulfonate treatment
    • Marec F., Socha R. Dose-response analysis of data obtained in the Drosophila wing spot test after ethyl methanesulfonate treatment. Acta Entomol. Bohemoslov. 84:1987;401-407.
    • (1987) Acta Entomol. Bohemoslov. , vol.84 , pp. 401-407
    • Marec, F.1    Socha, R.2
  • 51
    • 0023006294 scopus 로고
    • Induction of sister chromatid exchanges by inhibitors of topoisomerases
    • Lim M., Liu L.F., Jacobson-Kram D., Williams J.R. Induction of sister chromatid exchanges by inhibitors of topoisomerases. Cell Biol. Toxicol. 2:1986;485-494.
    • (1986) Cell Biol. Toxicol. , vol.2 , pp. 485-494
    • Lim, M.1    Liu, L.F.2    Jacobson-Kram, D.3    Williams, J.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.