메뉴 건너뛰기




Volumn 58, Issue 6, 2009, Pages 1373-1381

Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ B1 RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GELATINASE B; KININ; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38;

EID: 66649088302     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0329     Document Type: Article
Times cited : (96)

References (52)
  • 1
    • 33645280925 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: The search for a unifying hypothesis
    • DOI 10.1161/01.RES.0000207406.94146.c2, PII 0000301220060317000009
    • Poornima IG, Parikh P, Shannon RP. Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res 2006;98:596-605 (Pubitemid 43755278)
    • (2006) Circulation Research , vol.98 , Issue.5 , pp. 596-605
    • Poornima, I.G.1    Parikh, P.2    Shannon, R.P.3
  • 2
    • 33847342561 scopus 로고    scopus 로고
    • Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: The role of angiotensin type 1 receptor antagonism
    • DOI 10.2337/db06-1163
    • Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschope C. Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism. Diabetes 2007;56:641-646 (Pubitemid 46348458)
    • (2007) Diabetes , vol.56 , Issue.3 , pp. 641-646
    • Westermann, D.1    Rutschow, S.2    Jager, S.3    Linderer, A.4    Anker, S.5    Riad, A.6    Unger, T.7    Schultheiss, H.-P.8    Pauschinger, M.9    Tschope, C.10
  • 3
    • 50949093909 scopus 로고    scopus 로고
    • Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy
    • Zhang L, Cannell MB, Phillips AR, Cooper GJ, Ward ML. Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy. Diabetes 2008;57:2158-2166
    • (2008) Diabetes , vol.57 , pp. 2158-2166
    • Zhang, L.1    Cannell, M.B.2    Phillips, A.R.3    Cooper, G.J.4    Ward, M.L.5
  • 7
    • 0033958237 scopus 로고    scopus 로고
    • Kallikrein gene delivery attenuates myocardial infarction and apoptosis after myocardial ischemia and reperfusion
    • Yoshida H, Zhang JJ, Chao L, Chao J. Kallikrein gene delivery attenuates myocardial infarction and apoptosis after myocardial ischemia and reperfusion. Hypertension 2000;35:25-31 (Pubitemid 30054232)
    • (2000) Hypertension , vol.35 , Issue.1 , pp. 25-31
    • Yoshida, H.1    Zhang, J.J.2    Chao, L.3    Chao, J.4
  • 8
    • 33845580042 scopus 로고    scopus 로고
    • Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3β activation
    • DOI 10.1016/j.cardiores.2006.10.014, PII S0008636306004718
    • Li HJ, Yin H, Yao YY, Shen B, Bader M, Chao L, Chao J. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Cardiovasc Res 2007;73:130-142 (Pubitemid 44937189)
    • (2007) Cardiovascular Research , vol.73 , Issue.1 , pp. 130-142
    • Li, H.-J.1    Yin, H.2    Yao, Y.-Y.3    Shen, B.4    Bader, M.5    Chao, L.6    Chao, J.7
  • 9
    • 0141565389 scopus 로고    scopus 로고
    • Kallikrein gene delivery attenuates cardiac remodeling and promotes neovascularization in spontaneously hypertensive rats
    • Bledsoe G, Chao L, Chao J. Kallikrein gene delivery attenuates cardiac remodeling and promotes neovascularization in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2003;285:H1479-H1488 (Pubitemid 37169501)
    • (2003) American Journal of Physiology - Heart and Circulatory Physiology , vol.285 , Issue.4
    • Bledsoe, G.1    Chao, L.2    Chao, J.3
  • 10
    • 28744441357 scopus 로고    scopus 로고
    • Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    • DOI 10.1096/fj.05-4095fje
    • Tschope C, Walther T, Escher F, Spillmann F, Du J, Altmann C, Schimke I, Bader M, Sanchez-Ferrer CF, Schultheiss HP, Noutsias M: Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction, and oxidative stress in experimental diabetic cardiomyopathy. FASEB J 19:2057-2059, 2005 (Pubitemid 41759764)
    • (2005) FASEB Journal , vol.19 , Issue.14 , pp. 2057-2059
    • Tschope, C.1    Walther, T.2    Escher, F.3    Spillmann, F.4    Du, J.5    Altmann, C.6    Schimke, I.7    Bader, M.8    Sanchez-Ferrer, C.F.9    Schultheiss, H.-P.10    Noutsias, M.11
  • 11
    • 54749130441 scopus 로고    scopus 로고
    • Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation
    • Chao J, Yin H, Gao L, Hagiwara M, Shen B, Yang ZR, Chao L. Tissue kallikrein elicits cardioprotection by direct kinin b2 receptor activation independent of kinin formation. Hypertension 2008;52:715-720
    • (2008) Hypertension , vol.52 , pp. 715-720
    • Chao, J.1    Yin, H.2    Gao, L.3    Hagiwara, M.4    Shen, B.5    Yang, Z.R.6    Chao, L.7
  • 14
    • 0036892383 scopus 로고    scopus 로고
    • Regulation of cardiac bradykinin B1- And B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload-induced cardiomyopathy
    • DOI 10.1016/S1567-5769(02)00174-1, PII S1567576902001741
    • Spillmann F, Altmann C, Scheeler M, Barbosa M, Westermann D, Schultheiss HP, Walther T, Tschope C. Regulation of cardiac bradykinin B1- and B2-receptor mRNA in experimental ischemic, diabetic, and pressure-overload- induced cardiomyopathy. Int Immunopharmacol 2002;2:1823-1832 (Pubitemid 35373923)
    • (2002) International Immunopharmacology , vol.2 , Issue.13-14 , pp. 1823-1832
    • Spillmann, F.1    Altmann, C.2    Scheeler, M.3    Barbosa, M.4    Westermann, D.5    Schultheiss, H.-P.6    Walther, T.7    Tschope, C.8
  • 18
    • 0037414639 scopus 로고    scopus 로고
    • 9-bradykinin and susceptibility to inflammation
    • DOI 10.1074/jbc.M209490200
    • Ni A, Yin H, Agata J, Yang Z, Chao L, Chao J. Overexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammation. J Biol Chem 2003;278:219-225 (Pubitemid 36043565)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 219-225
    • Ni, A.1    Yin, H.2    Agata, J.3    Yang, Z.4    Chao, L.5    Chao, J.6
  • 19
    • 34447627156 scopus 로고    scopus 로고
    • Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling
    • DOI 10.1016/j.peptides.2007.05.010, PII S0196978107001726
    • Yin H, Chao J, Bader M, Chao L. Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Peptides 2007;28:1383-1389 (Pubitemid 47088743)
    • (2007) Peptides , vol.28 , Issue.7 , pp. 1383-1389
    • Yin, H.1    Chao, J.2    Bader, M.3    Chao, L.4
  • 24
    • 33645037187 scopus 로고    scopus 로고
    • Effects of insulin treatment on heart rhythm, body temperature and physical activity in streptozotocin-induced diabetic rat
    • Howarth FC, Jacobson M, Shafiullah M, Adeghate E. Effects of insulin treatment on heart rhythm, body temperature and physical activity in streptozotocin-induced diabetic rat. Clin Exp Pharmacol Physiol 2006;33: 327-331
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 327-331
    • Howarth, F.C.1    Jacobson, M.2    Shafiullah, M.3    Adeghate, E.4
  • 26
    • 17844374680 scopus 로고    scopus 로고
    • Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats
    • DOI 10.2337/diabetes.54.5.1573
    • Montanari D, Yin H, Dobrzynski E, Agata J, Yoshida H, Chao J, Chao L. Kallikrein gene delivery improves serum glucose and lipid profiles and cardiac function in streptozotocin-induced diabetic rats. Diabetes 2005;54: 1573-1580 (Pubitemid 40586692)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1573-1580
    • Montanari, D.1    Yin, H.2    Dobrzynski, E.3    Agata, J.4    Yoshida, H.5    Chao, J.6    Chao, L.7
  • 27
    • 33847033769 scopus 로고    scopus 로고
    • Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction
    • DOI 10.1016/j.regpep.2006.11.020, PII S0167011506002175
    • Yao YY, Yin H, Shen B, Chao L, Chao J. Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction. Regul Pept 2007;140:12-20 (Pubitemid 46275053)
    • (2007) Regulatory Peptides , vol.140 , Issue.1-2 , pp. 12-20
    • Yao, Y.-Y.1    Yin, H.2    Shen, B.3    Chao, L.4    Chao, J.5
  • 29
    • 0036841281 scopus 로고    scopus 로고
    • Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction
    • DOI 10.1161/01.HYP.0000036035.41122.99
    • Agata J, Chao L, Chao J. Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction. Hypertension 2002; 40:653-659 (Pubitemid 35278601)
    • (2002) Hypertension , vol.40 , Issue.5 , pp. 653-659
    • Agata, J.1    Chao, L.2    Chao, J.3
  • 32
    • 0030175333 scopus 로고    scopus 로고
    • Cardiac kallikrein in hypertensive and normotensive rats with and without diabetes
    • DOI 10.1016/0162-3109(96)00104-X
    • Sharma JN, Kesavarao U. Cardiac kallikrein in hypertensive and normotensive rats with and without diabetes. Immunopharmacology 1996;33: 341-343 (Pubitemid 26247964)
    • (1996) Immunopharmacology , vol.33 , Issue.1-3 , pp. 341-343
    • Sharma, J.N.1    Kesavarao, U.2
  • 33
    • 0035985324 scopus 로고    scopus 로고
    • 1 receptors in myocardial ischemia: Evidence from pharmacological blockade and gene knockout mice
    • DOI 10.1016/S1567-5769(02)00022-X, PII S156757690200022X
    • Lagneux C, Bader M, Pesquero JB, Demenge P, Ribuot C. Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice. Int Immunopharmacol 2002;2:815-822 (Pubitemid 34603126)
    • (2002) International Immunopharmacology , vol.2 , Issue.6 , pp. 815-822
    • Lagneux, C.1    Bader, M.2    Pesquero, J.B.3    Demenge, P.4    Ribuot, C.5
  • 34
    • 32344435146 scopus 로고    scopus 로고
    • The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: Evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy
    • DOI 10.1515/BC.2006.018
    • Gabra BH, Berthiaume N, Sirois P, Nantel F, Battistini B. The kinin system mediates hyperalgesia through the inducible bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy. Biol Chem 2006;387:127-143 (Pubitemid 43221825)
    • (2006) Biological Chemistry , vol.387 , Issue.2 , pp. 127-143
    • Gabra, B.H.1    Berthiaume, N.2    Sirois, P.3    Nantel, F.4    Battistini, B.5
  • 36
    • 60549111207 scopus 로고    scopus 로고
    • Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    • Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, Stoll G, Renne T, Kleinschnitz C. Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 2009;40:285-293
    • (2009) Stroke , vol.40 , pp. 285-293
    • Austinat, M.1    Braeuninger, S.2    Pesquero, J.B.3    Brede, M.4    Bader, M.5    Stoll, G.6    Renne, T.7    Kleinschnitz, C.8
  • 37
    • 34249900489 scopus 로고    scopus 로고
    • IL-1beta-induced transcriptional up-regulation of bradykinin B1 and B2 receptors in murine airways
    • Zhang Y, Adner M, Cardell LO. IL-1beta-induced transcriptional up-regulation of bradykinin B1 and B2 receptors in murine airways. Am J Respir Cell Mol Biol 2007;36:697-705
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 697-705
    • Zhang, Y.1    Adner, M.2    Cardell, L.O.3
  • 39
    • 1242329230 scopus 로고    scopus 로고
    • Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists
    • DOI 10.1007/s00011-003-1226-0
    • Gama Landgraf R, Jancar S, Steil AA, Sirois P. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Inflamm Res 2004;53:78-83 (Pubitemid 38223373)
    • (2004) Inflammation Research , vol.53 , Issue.2 , pp. 78-83
    • Gama Landgraf, R.1    Steil, A.A.2    Sirois, P.3    Jancar, S.4
  • 40
    • 42349110618 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition after experimental myocardial infarct: Role of the kinin B1 and B2 receptors
    • Duka A, Kintsurashvili E, Duka I, Ona D, Hopkins TA, Bader M, Gavras I, Gavras H. Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptors. Hypertension 2008;51:1352-1357
    • (2008) Hypertension , vol.51 , pp. 1352-1357
    • Duka, A.1    Kintsurashvili, E.2    Duka, I.3    Ona, D.4    Hopkins, T.A.5    Bader, M.6    Gavras, I.7    Gavras, H.8
  • 41
    • 47549097379 scopus 로고    scopus 로고
    • Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor
    • Westermann D, Lettau O, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschope C. Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor. Biol Chem 2008;389:713-718
    • (2008) Biol Chem , vol.389 , pp. 713-718
    • Westermann, D.1    Lettau, O.2    Sobirey, M.3    Riad, A.4    Bader, M.5    Schultheiss, H.P.6    Tschope, C.7
  • 42
    • 60349086455 scopus 로고    scopus 로고
    • The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice
    • Xu J, Carretero OA, Shesely EG, Rhaleb NE, Yang JJ, Bader M, Yang XP. The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in mice. Exp Physiol 2008;94:322-329
    • (2008) Exp Physiol , vol.94 , pp. 322-329
    • Xu, J.1    Carretero, O.A.2    Shesely, E.G.3    Rhaleb, N.E.4    Yang, J.J.5    Bader, M.6    Yang, X.P.7
  • 43
    • 0035876332 scopus 로고    scopus 로고
    • p38 stress-activated protein kinase inhibitor reverses bradykinin B(1) receptor-mediated component of inflammatory hyperalgesia
    • Ganju P, Davis A, Patel S, Nunez X, Fox A. p38 stress-activated protein kinase inhibitor reverses bradykinin B(1) receptor-mediated component of inflammatory hyperalgesia. Eur J Pharmacol 2001;421:191-199
    • (2001) Eur J Pharmacol , vol.421 , pp. 191-199
    • Ganju, P.1    Davis, A.2    Patel, S.3    Nunez, X.4    Fox, A.5
  • 44
    • 33646829136 scopus 로고    scopus 로고
    • TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling
    • DOI 10.1074/jbc.M507610200
    • Lu G, Kang YJ, Han J, Herschman HR, Stefani E, Wang Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. J Biol Chem 2006;281:6087-6095 (Pubitemid 43847710)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.9 , pp. 6087-6095
    • Lu, G.1    Young, J.K.2    Han, J.3    Herschman, H.R.4    Stefani, E.5    Wang, Y.6
  • 45
    • 33748515649 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    • DOI 10.1007/s00125-006-0385-2
    • Westermann D, Rutschow S, Van Linthout S, Linderer A, Bucker-Gartner C, Sobirey M, Riad A, Pauschinger M, Schultheiss HP, Tschope C. Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Diabetologia 2006;49:2507-2513 (Pubitemid 44359113)
    • (2006) Diabetologia , vol.49 , Issue.10 , pp. 2507-2513
    • Westermann, D.1    Rutschow, S.2    Van Linthout, S.3    Linderer, A.4    Bucker-Gartner, C.5    Sobirey, M.6    Riad, A.7    Pauschinger, M.8    Schultheiss, H.-P.9    Tschope, C.10
  • 46
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: The good, the bad, or the indifferent?
    • Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 2004;54 (Suppl. 2):S114-S124
    • (2004) Diabetes , vol.54 , Issue.SUPPL. 2
    • Kristiansen, O.P.1    Mandrup-Poulsen, T.2
  • 47
    • 34447520043 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
    • DOI 10.1038/nrd2308, PII NRD2308
    • Hu J, Van den Steen PE, Sang QX, Opdenakker G. Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov 2007;6:480-498 (Pubitemid 47064570)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.6 , pp. 480-498
    • Hu, J.1    Van Den Steen, P.E.2    Sang, Q.-X.A.3    Opdenakker, G.4
  • 48
    • 0035170255 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy
    • DOI 10.1038/nm1101-1202
    • Wielockx B, Lannoy K, Shapiro SD, Itoh T, Itohara S, Vandekerckhove J, Libert C. Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy. Nat Med 2001;7:1202-1208 (Pubitemid 33063775)
    • (2001) Nature Medicine , vol.7 , Issue.11 , pp. 1202-1208
    • Wielockx, B.1    Lannoy, K.2    Shapiro, S.D.3    Itoh, T.4    Itohara, S.5    Vandekerckhove, J.6    Libert, C.7
  • 49
    • 3142654125 scopus 로고    scopus 로고
    • Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1
    • DOI 10.1016/j.cellsig.2004.03.021, PII S0898656804000488
    • Hsieh HL, Yen MH, Jou MJ, Yang CM. Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1. Cell Signal 2004;16:1163-1176 (Pubitemid 38900519)
    • (2004) Cellular Signalling , vol.16 , Issue.10 , pp. 1163-1176
    • Hsieh, H.-L.1    Yen, M.-H.2    Jou, M.-J.3    Yang, C.-M.4
  • 50
    • 42449094278 scopus 로고    scopus 로고
    • A novel inflammatory pathway involved in leukocyte recruitment: Role for the kinin B1 receptor and the chemokine CXCL5
    • Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A. A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol 2007;179:4849-4856
    • (2007) J Immunol , vol.179 , pp. 4849-4856
    • Duchene, J.1    Lecomte, F.2    Ahmed, S.3    Cayla, C.4    Pesquero, J.5    Bader, M.6    Perretti, M.7    Ahluwalia, A.8
  • 51
    • 0034724461 scopus 로고    scopus 로고
    • 10-kallidin engagement of the B1 receptor stimulates type I collagen synthesis via stabilization of connective tissue growth factor mRNA
    • DOI 10.1074/jbc.275.17.12475
    • Ricupero DA, Romero JR, Rishikof DC, Goldstein RH. Des-Arg(10)-kallidin engagement of the B1 receptor stimulates type I collagen synthesis via stabilization of connective tissue growth factor mRNA. J Biol Chem 2000;275:12475-12480 (Pubitemid 30241390)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.17 , pp. 12475-12480
    • Ricupero, D.A.1    Romero, J.R.2    Rishikof, D.C.3    Goldstein, R.H.4
  • 52
    • 33644862200 scopus 로고    scopus 로고
    • Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation
    • DOI 10.1161/CIRCULATIONAHA.105.537894, PII 0000301720060131000013
    • Wang J, Song Y, Elsherif L, Song Z, Zhou G, Prabhu SD, Saari JT, Cai L. Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation 2006;113: 544-554 (Pubitemid 43754355)
    • (2006) Circulation , vol.113 , Issue.4 , pp. 544-554
    • Wang, J.1    Song, Y.2    Elsherif, L.3    Song, Z.4    Zhou, G.5    Prabhu, S.D.6    Saari, J.T.7    Cai, L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.