Prolactin alters the mechanisms of B cell tolerance induction

Arthritis and Rheumatism

Volumn 60, Issue 6, 2009, Pages 1743-1752

  Saha, Subhrajit ^a   Gonzalez, Juana ^a   Rosenfeld, Gabriel ^a   Keiser, Harold ^a   Peeva, Elena ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CALCIUM; CHECKPOINT KINASE 2; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR II; GENE PRODUCT; NUCLEAR FACTOR KAPPA B2; PROLACTIN; PROTEIN BIRC 1; PROTEIN MCL 1; PROTEIN TRP63; PROTEIN TRP73; SEX HORMONE; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CALCIUM TRANSPORT; CELL PROLIFERATION; CLONAL ANERGY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HYPERPROLACTINEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LIGHT CHAIN; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL; UPREGULATION;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HYPERPROLACTINEMIA; IMMUNE TOLERANCE; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; MICE; MICE, INBRED BALB C; PHOSPHOPROTEINS; PROLACTIN; RECEPTORS, INTERFERON; TRANS-ACTIVATORS;

EID: 66449129213     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24500     Document Type: Article

References (50)

1. Walker S, McMurray R, Houri J, Allen S, Keisler D, Sharp G, et al. Effects of prolactin in stimulating disease activity in systemic lupus erythematosus. Ann N Y Acad Sci 1998;840:762-772 (Pubitemid 28302102)
2. Kucharz E, Jarczyk R, Jonderko G, Rubisz-Brezezinska J, Brzezinska-Wcislo L. High serum level of prolactin in patients with systemic sclerosis. Clin Rheumatol 1996;15:314 (Pubitemid 26186516)
3. Azar S, Yamout B. Prolactin secretion is increased in patients with multiple sclerosis. Endocr Res 1999;25:207-214 (Pubitemid 29269400)
4. Jara L, Gomez-Sanchez C, Silveira LH, Martinez-Osuna P, Vasey FB, Espinoza LR. Hyperprolactinemia in systemic lupus erythematosus: association with disease activity. Am J Med Sci 1992;303:222-226
5. Mirone L, Barini A, Barini A. Androgen and prolactin (Prl) levels in systemic sclerosis (SSc): relationship to disease severity. Ann N Y Acad Sci 2006;1069:257-262 (Pubitemid 43989868)
6. Olsen N, Kovacs W. Hormones, pregnancy, and rheumatoid arthritis. Gend Specif Med 2002:28-37. (Pubitemid 35469409)
7. Mattsson R, Mattsson A, Hansson I, Holmdahl R, Rook G, Whyte A. Increased levels of prolactin during, but not after, the immunisation with rat collagen II enhances the course of arthritis in DBA/1 mice. Autoimmunity 1992;11:163-170
8. Berczi I, Nagy E. A possible role of prolactin in adjuvant arthritis. Arthritis Rheum 1982;25:591-594
9. Dijkstra C, van der Voort E, De Groot C, Huitinga I, Uitdehaag B, Polman C, et al. Therapeutic effect of the D2-dopamine agonist bromocriptine on acute and relapsing experimental allergic encephalomyelitis. Psychoneuroendocrinology 1994;19:135-142 (Pubitemid 24182342)
10. Mc Murray R. Prolactin in murine systemic lupus erythematosus. Lupus 2001;10:742-747 (Pubitemid 33041667)
11. Peeva E, Michael D, Cleary J, Rice J, Chen X, Diamond B. Prolactin modulates the naive B cell repertoire. J Clin Invest 2003;111:275-283 (Pubitemid 36105927)
12. Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, et al. Identification of anergic B cells within a wild-type repertoire. Immunity 2006;25:953-962 (Pubitemid 44894955)
13. Peeva E, Venkatesh J, Diamond B. Tamoxifen blocks estrogen-induced B cell maturation but not survival. J Immunol 2005;175:1415-1423 (Pubitemid 41023040)
14. Lyons A, Parish C. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994;171:131-137 (Pubitemid 24140219)
15. De St. Groth SF, Scheidegger D. Production of monoclonal antibodies: strategy and tactics. J Immunol Methods 1980;35:1-21. (Pubitemid 10034772)
16. Peeva E, Grimaldi C, Spatz L, Diamond B. Bromocriptine restores tolerance in estrogen-treated mice. J Clin Invest 2000;106:1373-1379
17. Ehlich A, Martin V, Muller W, Rajewsky K. Analysis of the B-cell progenitor compartment at the level of single cells. Curr Biol 1994;4:573-583 (Pubitemid 2110965)
18. -/- small pre-BII cells have no L chain gene rearrangements: detection by high-efficiency single cell PCR. Immunity 1999;11:309-316
19. Loder F, Mutschler B, Ray R, Paige C, Sideras P, Torres R, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med 1999;190:75-89. (Pubitemid 29330125)
20. Su T, Rawlings D. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J Immunol 2002;168:2101-2110 (Pubitemid 34171808)
21. Petro J, Gerstein R, Lowe J, Carter R, Shinners N, Khan W. Transitional type 1 and 2 B lymphocyte subsets are differentially responsive to antigen receptor signaling. J Biol Chem 2002;277:48009-48019 (Pubitemid 35470746)
22. Teague B, Pan Y, Mudd P, Nakken B, Zhang Q, Szodoray P, et al. Cutting edge: transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. J Immunol 2007;178:7511-7515 (Pubitemid 46898017)
23. Koshy M, Berger D, Crow M. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J Clin Invest 1996;98:826-837 (Pubitemid 26349188)
24. Sater R, Sandel P, Monroe J. B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help. Int Immunol 1998;10:1673-1682 (Pubitemid 28502381)
25. Buckley A. Prolactin, lymphocyte growth and survival factor. Lupus 2001;10:684-690
26. Batten M, Groom J, Cachero TG, Qian F, Schneider P, Tschopp J, et al. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 2000;192:1453-1466
27. + arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice. Cell Immunol 2005;238:38-48.
28. Nemazee D. Receptor editing in B cells. Adv Immunol 2000;74:89-126.
29. Peeva E, Venkatesh J, Michael D, Diamond B. Prolactin as a modulator of B cell function; implications for SLE. Biomed Pharmacother 2004;58:310-319 (Pubitemid 38759730)
30. Wardemann H, Yurasov S, Schaefer A, Young J, Meffre E, Nussenzweig M. Predominant autoantibody production by early human B cell precursors. Science 2003;301:1374-1377 (Pubitemid 37075812)
31. Nemazee DA, Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989;337:562-566 (Pubitemid 19045542)
32. Chung JB, Sater RA, Fields ML, Erikson J, Monroe JG. CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals. Int Immunol 2002;14:157-166 (Pubitemid 34144740)
33. Carsetti R, Kohler G, Lamers M. Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med 1995;181:2129-2140
34. Niiro H, Clark EA. Regulation of B-cell fate by antigen-receptor signals. Nat Rev Immunol 2002;2:945-956 (Pubitemid 37323215)
35. Rice JS, Newman J, Wang C, Michael DJ, Diamond B. Receptor editing in peripheral B cell tolerance. Proc Natl Acad Sci U S A 2005;102:1608-1613 (Pubitemid 40209215)
36. Radic MZ, Erikson J, Litwin S, Weigert M. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 1993;177:1165-1173 (Pubitemid 23097405)
37. Gay D, Saunders T, Camper S, Weigert M. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med 1993;177:999-1008. (Pubitemid 23097389)
38. Tiegs SL, Russell DM, Neamazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med 1993;177:1009-1020 (Pubitemid 23097390)
39. Li Y, Li H, Ni D, Weigert M. Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med 2002;196:1543-1552 (Pubitemid 36026466)
40. Kenny JJ, Rezanka LJ, Lustig A, Fischer RT, Yoder J, Marshall S, et al. Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors. J Immunol 2000;164:4111-4119 (Pubitemid 30215067)
41. Nossal GJ, Pike BL. Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc Natl Acad Sci U S A 1980;77:1602-1606 (Pubitemid 10073810)
42. Gauld SB, Benschop RJ, Merrell KT, Cambier J. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol 2005;6:1160-1167 (Pubitemid 41541794)
43. Melchers F. Anergic B cells caught in the act. Immunity 2006;25:864-867 (Pubitemid 44894951)
44. Liossis S, Kovacs B, Dennis G, Kammer G, Tsokos G. B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest 1996;98:2549-2557 (Pubitemid 26415075)
45. Liossis SN, Sfikakis PP, Tsokos GC. Immune cell signaling aberrations in human lupus. Immunol Res 1998;18:27-39. (Pubitemid 28419877)
46. Bynoe M, Grimaldi C, Diamond B. Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells. Proc Natl Acad Sci U S A 2000;97:2703-2708 (Pubitemid 30159235)
47. Grimaldi CM, Jeganathan V, Diamond B. Hormonal regulation of B cell development: 17β-estradiol impairs negative selection of high-affinity DNA-reactive B cells at more than one developmental checkpoint. J Immunol 2006;176:2703-2710 (Pubitemid 43306928)
48. Wilson J, Foster D. Textbook of endocrinology. 8th ed. Philadelphia: WB Saunders; 1992.
49. Elbourne K, Keisler D, McMurray RW. Differential effects of estrogen and prolactin on autoimmune disease in the NZB/NZW F1 mouse model of systemic lupus erythematosus. Lupus 1998;7:420-427 (Pubitemid 28410189)
50. Grimaldi C, Michael D, Diamond B. Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus. J Immunol 2001;167:1886-1890 (Pubitemid 32747492)