Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats

Journal of Hypertension

Volumn 23, Issue 1, 2005, Pages 193-201

  Xie, He Hui ^a   Miao, Chao Yu ^a   Jiang, Yuan Ying ^a   Su, Ding Feng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Atenolol; Baroreflex sensitivity; Blood pressure variability; End organ damage; Hypertension; Nitrendipine

Indexed keywords

ATENOLOL; DEOXYCORTICOSTERONE ACETATE; NITRENDIPINE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE VARIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; FEEDING; HEART LEFT VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPERTENSION; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT;

EID: 12344299349     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200501000-00030     Document Type: Article

References (29)

1. Matereon BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kochar MS, et al. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. N Engl J Med 1993; 328:914-921.
2. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003; 289:2560-2572.
3. Kikuya M, Hozawa A, Ohokubo T, Tsuji I, Michimata M, Matsubara M, et al. Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study. Hypertension 2000; 36:901-906.
4. Parati G, Mancia G. Blood pressure variability as a risk factor. Blood Press Monit 2001; 6:341-347.
5. Su DF, Miao CY. Functional studies of arterial baroreflex in conscious rats. Acta Pharmacol Sin 2002; 23:673-679.
6. Sleight P. The importance of autonomic nervous system in health and disease. Aust NZ J Med 1997; 27:467-473.
7. Du WM, Miao CY, Liu JG, Shen FM, Yang XQ, Su DF. Effects of long-term treatment with ketanserin on blood pressure variability and end-organ damage in spontaneously hypertensive rats. J Cardiovasc Pharmacol 2003; 41:233-239.
8. Liu JG, Xu LP, Chu ZX, Miao CY, Su DF. Contribution of blood pressure variability to the effect of nitrendipine on end-organ damage in spontaneously hypertensive rats. J Hypertens 2003; 21:1961-1967.
9. Guan S, Fox J, Mitchell KD, Navar LG. Angiotensin and angiotensin-converting enzyme tissue levels in two-kidney, one clip hypertensive rats. Hypertension 1992; 20:763-767.
10. Hirata Y, Matsuoka H, Suzuki E, Hayakawa H, Sugimoto T, Matsuda Y, et al. Role of endogenous ANP in DOCA-salt hypertensive rats: effects of a novel non-peptide antagonist for ANP receptor. Circulation 1993; 87:554-561.
11. Shan ZZ, Dai SM, Su DF. Arterial baroreflex deficit induced organ damage in sinoaortic denervated rats. J Cardiovasc Pharmacol 2001; 38:427-437.
12. Norman RA Jr, Coleman TG, Dent AC. Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive. Hypertension 1981; 3:119-125.
13. Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity. Circ Res 1969; 24:109-121.
14. Su DF, Chen L, Kong XB, Cheng Y. Determination of arterial baroreflex-blood pressure control in conscious rats. Acta Pharmacol Sin 2002; 23:103-109.
15. Su DF, Cerutti C, Barres C, Julien C, Vincent M, Paultre C, et al. Arterial baroreflex control of heart period is not related to blood pressure variability in conscious hypertensive and normotensive rats. Clin Exp Pharmacol Physiol 1992; 19:767-775.
16. Hayakawa H, Raij L. The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension. Hypertension 1997; 29:235-241.
17. Miao CY, Xie HH, Wang JJ, Su DF. Candesartan inhibits sinoaortic denervation-induced cardiovascular hypertrophy in rats. Acta Pharmacol Sin 2002; 23:713-720.
18. Miao CY, Tao X, Gong K, Zhang SH, Chu ZX, Su DF. Aterial remodeling in chronic sinoaortic-denervated rats. J Cardiovasc Pharmacol 2001; 37:6-15.
19. Kimula K, Tojo A, Matsuoka H, Sugimoto T. Renal arteriolar diameters in spontaneously hypertensive rats: vascular cast study. Hypertension 1991; 18:101-110.
20. Jin ZJ, About the evaluation of drug combination. Acta Pharmacol Sin 2004; 25:146-147.
21. Su DF, Xu LP, Miao CY, Xie HH, Shen FM, Jiang YY. Two useful methods for evaluating antihypertensive drugs in conscious freely moving rats. Acta Pharmacol Sin 2004; 25:148-151.
22. Xu LP, Miao CY, Shen FM, Jiang YY, Su DF. Synergism of atenolol and amlodipine on lowering and stabilizing blood pressure in spontaneously hypertensive rats. Fundam Clin Pharmacol 2004; 18:33-38.
23. Sica DA. Fixed-dose combination antihypertensive drugs. Do they have a role in rational therapy? Drugs 1994; 48:16-24.
24. Parati, G, Pomidossi, G, Albini, F, Malaspina D, Mancia G. Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension. J Hypertens 1987; 5:93-98.
25. Mancia G, Frattola A, Parati G, Santucciu C, Ulian L. Blood pressure variability and organ damage. J Cardiovasc Pharmacol 1994; 24(suppl A);S6-S11.
26. Sander D, Kukla C, Klingelhofer J, Winbeck K, Conrad B. Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis: a 3-year follow-up study. Circulation 2000; 102:1536-1541.
27. Su DF, Miao CY. Blood pressure variability and organ damage. Clin Exp Pharmacol Physiol 2001; 28:709-715.
28. Shan ZZ, Dai SM, Su DF. Relationship between baroreceptor reflex function and end-organ damage in spontaneously hypertensive rats. Am J Physiol 1999; 277:H1200-H1206.
29. Bristow JD, Honour AJ, Pickering GW, Sleight P, Smyth HS. Diminished baroreflex sensitivity in high blood pressure. Circulation 1969; 39: 48-54.