Interleukin-1 receptor-associated kinase 4 links innate immunity to the pathogenesis of rheumatoid arthritis

Arthritis and Rheumatism

Volumn 60, Issue 6, 2009, Pages 1571-1574

  Joosten, Leo A B ^a   Netea, Mihai G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; TOLL LIKE RECEPTOR;

ANGIOGENESIS; B LYMPHOCYTE; DRUG TARGETING; EDITORIAL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; INFECTIOUS COMPLICATION; INNATE IMMUNITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; T LYMPHOCYTE; TREATMENT PLANNING;

ANIMALS; ARTHRITIS, RHEUMATOID; DISEASE MODELS, ANIMAL; GENE KNOCK-IN TECHNIQUES; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MICE; TOLL-LIKE RECEPTORS;

EID: 66449104913     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24546     Document Type: Editorial

References (22)

1. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001;2:675-680 (Pubitemid 32747155)
2. Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 2005;6:1087-1095 (Pubitemid 41541786)
3. Li X. IRAK4 in TLR/IL-1R signaling: possible clinical applications. Eur J Immunol 2008;38:614-618
4. Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, et al. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J Exp Med 2007;204:1013-1024 (Pubitemid 46798146)
5. Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med 2007;204:1025-1036 (Pubitemid 46798147)
6. Koziczak-Holbro M, Joyce C, Gluck A, Kinzel B, Muller M, Tschopp C, et al. IRAK-4 kinase activity is required for interleukin- 1 (IL-1) receptor- and Toll-like receptor 7-mediated signaling and gene expression. J Biol Chem 2007;282:13552-13560 (Pubitemid 47100553)
7. Koziczak-Holbro M, Gluck A, Tschopp C, Mathison JC, Gram H. IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes. Eur J Immunol 2008;38:788-796
8. Rekhter M, Staschke K, Estridge T, Rutherford P, Jackson N, Gifford-Moore D, et al. Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation. Biochem Biophys Res Commun 2008;367:642-648
9. Koziczak-Holbro M, Littlewood-Evans A, Pollinger B, Kovarik J, Dawson J, Zenke G, et al. The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation. Arthritis Rheum 2009;60:1661-1671
10. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, et al. Critical roles for interleukin 1 and tumor necrosis factor α in antibody-induced arthritis. J Exp Med 2002;196:77-85. (Pubitemid 34747313)
11. Buma P, Groenenberg M, Rijken PF, van den Berg WB, Joosten L, Peters H. Quantitation of the changes in vascularity during arthritis in the knee joint of a mouse with a digital image analysis system. Anat Rec 2001;262:420-428 (Pubitemid 32250966)
12. Suzuki N, Suzuki S, Millar DG, Unno M, Hara H, Calzascia T, et al. A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 2006;311:1927-1932
13. Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, van den Bersselaar LA, Oppers-Walgreen B, et al. T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1β and interleukin-17. Arthritis Rheum 2008;58:98-108.
14. Abdollahi-Roodsaz S, Joosten LA, Helsen MM, Walgreen B, van Lent PL, van den Bersselaar LA, et al. Shift from Toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR- 4-mediated interleukin-17 production. Arthritis Rheum 2008;58:3753-3764
15. Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, Radstake TR, Matera G, Popa C, et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007;56:2957-2967 (Pubitemid 47502742)
16. Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 2008;118:205-216
17. Millykangas-Luosujarvi R, Aho K, Kautiainen H, Isomaki H. Shortening of life span and causes of excess mortality in a population-based series of subjects with rheumatoid arthritis. Clin Exp Rheumatol 1995;13:149-153
18. Caporali R, Caprioli M, Bobbio-Pallavicini F, Montecucco C. DMARDS and infections in rheumatoid arthritis. Autoimmun Rev 2008;8:139-143
19. Crawford M, Curtis JR. Tumor necrosis factor inhibitors and infection complications. Curr Rheumatol Rep 2008;10:383-389
20. Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003;299:2076-2079 (Pubitemid 36383736)
21. Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med 2007;204:2407-2422 (Pubitemid 47529326)
22. Bustamante J, Boisson-Dupuis S, Jouanguy E, Picard C, Puel A, Abel L, et al. Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases. Curr Opin Immunol 2008;20:39-48.