Optically active antifungal azoles. X. Synthesis and antifungal activity of N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 12, 2000, Pages 1935-1946

  Kitazaki, Tomoyuki ^b   Ichikawa, Takashi ^a   Tasaka, Akihiro ^b   Hosono, Hiroshi ^b   Matsushita, Yoshihiro ^a   Hayashi, Ryogo ^c   Okonogi, Kenji ^d   Itoh, Katsumi ^a  

^a Dainippon Sumitomo Pharma   (Japan)

^b Medicinal Chemistry Research Laboratories II   (Japan)

^c Takeda Chem Indust L   (Japan)

^d TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1,2,3 trisubstituted 2 butanol; Antifungal activity; Imidazolidinone; Imidazolone; Optically active antifungal azole; S tereo controlled synthesis; Triazolone

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 2 BUTANOL; ANTIFUNGAL AGENT; IMIDAZOLINE DERIVATIVE; N [4 (AZOLYL)PHENYL] N' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL]AZOLONE; N [4 (AZOLYLMETHYL)PHENYL] N' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL]AZOLONE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN;

EID: 0034529717     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.1935     Document Type: Article

References (36)