Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 5, 2000, Pages 694-707

  Oida, Sadao ^a   Tajima, Yawara ^a   Konosu, Toshiyuki ^a   Nakamura, Yoshie ^a   Somada, Atsushi ^a   Tanaka, Teruo ^a   Habuki, Shinobu ^a   Harasaki, Tamako ^a   Kamai, Yasuki ^a   Fukuoka, Takashi ^a   Ohya, Satoshi ^a   Yasuda, Hiroshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Antifungal; Lanosterol 14 demethylase; R 102557; Structure activity relationship; Synthesis; Triazole

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 [2 [4 [4 (2,2,3,3 TETRAFLUOROPROPOXY)PHENYL] 1,3 BUTADIENYL] 1,3 DIOXAN 5 YLTHIO] 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; ANTIFUNGAL AGENT; CYTOCHROME P450; ERGOSTEROL; FLUCONAZOLE; ITRACONAZOLE; LANOSTEROL DERIVATIVE; POSACONAZOLE; RAVUCONAZOLE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MYCOSIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0034126218     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.694     Document Type: Article

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