Synthesis and in vitro antifungal activities of novel triazole antifungal agent CS-758

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 12, 2001, Pages 1647-1650

  Konosu, Toshiyuki ^a   Oida, Sadao ^a   Nakamura, Yoshie ^a   Seki, Shinobu ^a   Uchida, Takuya ^a   Somada, Atsushi ^a   Mori, Makoto ^a   Harada, Yoshiko ^a   Kamai, Yasuki ^b   Harasaki, Tamako ^b   Fukuoka, Takashi ^b   Ohya, Satoshi ^b   Yasuda, Hiroshi ^b   Shibayama, Takahiro ^c   Inoue, Shin Ichi ^c   Nakagawa, Akihiko ^c   Seta, Yasuo ^d  

^a Exploratory Chemistry Research Laboratories   (Japan)

^b Biological Research Laboratories   (Japan)

^c Drug Metabolism and Pharmacokinetics Research Laboratories   (Japan)

^d DAIICHI SANKYO CO   (Japan)

Author keywords

Antifungal; CS 758; Horner Wadsworth Emmons reaction; R 120758; Triazole

Indexed keywords

4 [4 [5 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4, TRIAZOL 1 YL)PROPYLTHIO] 1,3 DIOXAN 2 YL] 1,3 BUTADIENYL] 3 FLUOROBENZONITIRLE; ALDEHYDE; ANTIFUNGAL AGENT; BENZENE; BENZONITRILE; DIOXANE; DIOXANE DERIVATIVE; FLUCONAZOLE; FLUORINE; ITRACONAZOLE; NITRILE; PHENYL GROUP; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA; CHEMICAL BOND; CHEMICAL REACTION; CRYPTOCOCCUS; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRECURSOR; STEREOCHEMISTRY;

ANTIFUNGAL AGENTS; FLUCONAZOLE; FUNGI; INDICATORS AND REAGENTS; ITRACONAZOLE; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; TRIAZOLES;

EID: 0035209176     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1647     Document Type: Article

References (7)