Optically active antifungal azoles. XII. Synthesis and antifungal activity of the water-soluble prodrugs of 1-[(1R,2R)-2-(2,4difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1- yl)propyl]3-[4-(1H-1-tetrazolyl) phenyl]-2-imidazolidinone

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 9, 2001, Pages 1102-1109

  Ichikawa, T ^a   Kitazaki, T ^a   Matsushita, Y ^a   Yamada, M ^a   Hayashi, R ^a   Yamaguchi, M ^a   Kiyota, Y ^a   Okonogi, K ^a   Itoh, K ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1,2,3 trisubstituted 2 butanol; Antifungal azole; TAK 456; TAK 457; Triazolium salt; Water soluble prodrug

Indexed keywords

1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 3 [4 (1H 1 TETRAZOLYL)PHENYL] 2 IMIDAZOLIDINONE; 1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4 TRIAZOL 1 YL)PROPYL] 3 [4 (1H TETRAZOL 1 YL)PHENYL] 2 IMIDAZOLIDINONE; 4 ACETOXYMETHYL 1 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [2 OXO 3 [4 (1H 1 TETRAZOLYL)PHENYL] 1 IMIDAZOLIDINYL]BUTYL] 1H 1,2,4 TRIAZOLIUM CHLORIDE; ANTIFUNGAL AGENT; PRODRUG; TAK 457; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CLINICAL TRIAL; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MOUSE; NONHUMAN; RAT;

ALKYLATION; ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; AZOLES; CANDIDA ALBICANS; CANDIDIASIS; HALF-LIFE; HEMOLYSIS; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; PRODRUGS; RATS; SOLUBILITY; TETRAZOLES;

EID: 0034854377     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.1102     Document Type: Article

References (31)