GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1738, Issue 1-3, 2005, Pages 37-47

  Dishart, David ^a   Schnur, Nicole ^b   Klan, Niko ^b   Werz, Oliver ^a,b   Steinhilber, Dieter ^b   Samuelsson, Bengt ^a   Rådmark, Olof ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Arachidonic acid; Egr 1; Eicosanoid; Leukotriene; Sp1

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; COLECALCIFEROL; EARLY GROWTH RESPONSE FACTOR 1; LEUKOTRIENE; MITHRAMYCIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BINDING SITE; CATALYSIS; CELL DIFFERENTIATION; CELL LINE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; GC RICH SEQUENCE; GENE ACTIVITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ARACHIDONATE 5-LIPOXYGENASE; BINDING SITES; CELL DIFFERENTIATION; CELL LINE; EARLY GROWTH RESPONSE PROTEIN 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GC RICH SEQUENCE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MONOCYTES; PLICAMYCIN; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION INITIATION SITE;

EID: 31144452788     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2005.11.008     Document Type: Article

References (42)

1. B. Samuelsson, S.-E. Dahlén, J.-Å. Lindgren, C.A. Rouzer, and C.N. Serhan Leukotrienes and lipoxins: structures, biosynthesis, and biological effects Science 237 1987 1171 1176
2. D. Steinberg Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime Nat. Med. 8 2002 1211 1217
3. K. Lotzer, C.D. Funk, and A.J. Habenicht The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis Biochim. Biophys. Acta 1736 2005 30 37
4. C.D. Funk Leukotriene modifiers as potential therapeutics for cardiovascular disease Nat. Rev., Drug Discov. 4 2005 664 672
5. J.E. Jones, J.L. Walker, Y. Song, N. Weiss, W.V. Cardoso, R.M. Tuder, J. Loscalzo, and Y.Y. Zhang Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats Am. J. Physiol., Heart Circ. Physiol. 286 2004 H1775 H1784
6. N.S. Patel, S. Cuzzocrea, P.K. Chatterjee, R. Di Paola, L. Sautebin, D. Britti, and C. Thiemermann Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton Mol. Pharmacol. 66 2004 220 227
7. M. Romano, and J. Claria Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy FASEB J. 17 2003 1986 1995
8. C.D. Funk, S. Hoshiko, T. Matsumoto, O. Rådmark, and B. Samuelsson Characterization of the human 5-lipoxygenase gene Proc. Natl. Acad. Sci. U. S. A. 86 1989 2587 2591
9. S. Hoshiko, O. Radmark, and B. Samuelsson Characterization of the human 5-lipoxygenase gene promoter Proc. Natl. Acad. Sci. U. S. A. 87 1990 9073 9077
10. K.H. In, K. Asano, D. Beier, J. Grobholz, P.W. Finn, E.K. Silverman, E.S. Silverman, T. Collins, A.R. Fischer, T.P. Keith, K. Serino, S.W. Kim, G.T. DeSanctis, C. Yandava, A. Pillari, P. Rubin, J. Kemp, E. Israel, W. Busse, D. Ledford, J.J. Murray, A. Segal, D. Tinkleman, and J.M. Drazen Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription J. Clin. Invest. 99 1997 1130 1137
11. E.S. Silverman, J. Du, G.T. De Sanctis, O. Radmark, B. Samuelsson, J.M. Drazen, and T. Collins Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants Am. J. Respir. Cell Mol. Biol. 19 1998 316 323
12. J.M. Drazen, C.N. Yandava, L. Dube, N. Szczerback, R. Hippensteel, A. Pillari, E. Israel, N. Schork, E.S. Silverman, D.A. Katz, and J. Drajesk Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment Nat. Genet. 22 1999 168 170
13. J.H. Dwyer, H. Allayee, K.M. Dwyer, J. Fan, H. Wu, R. Mar, A.J. Lusis, and M. Mehrabian Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis N. Engl. J. Med. 350 2004 29 37
14. E.S. Silverman, L. Le, R.M. Baron, A. Hallock, J. Hjoberg, T. Shikanai, K.S.V. Gravesande, P.E. Auron, and W.N. Lu Cloning and functional analysis of the mouse 5-lipoxygenase promoter Am. J. Respir. Cell Mol. Biol. 26 2002 475 483
15. M. Brungs, O. Radmark, B. Samuelsson, and D. Steinhilber Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D-3 Proc. Natl. Acad. Sci. U. S. A. 92 1995 107 111
16. D. Harle, O. Radmark, B. Samuelsson, and D. Steinhilber Calcitriol and transforming growth factor-beta upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation Eur. J. Biochem. 254 1998 275 281
17. D. Harle, O. Radmark, B. Samuelsson, and D. Steinhilber Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3 Adv. Exp. Med. Biol. 469 1999 105 111
18. J. Uhl, N. Klan, M. Rose, K.-D. Entian, O. Werz, and D. Steinhilber The 5-lipoxygenase promoter is regulated by DNA methylation J. Biol. Chem. 277 2002 4374 4379
19. N. Klan, S. Seuter, N. Schnur, M. Jung, and D. Steinhilber Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity Biol. Chem. 384 2003 777 785
20. R. Ray, R.C. Snyder, S. Thomas, C.A. Koller, and D.M. Miller Mithramycin blocks protein binding and function of the SV40 early promoter J. Clin. Invest. 83 1989 2003 2007
21. P. Greenwel, Y. Inagaki, W. Hu, M. Walsh, and F. Ramirez Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1 J. Biol. Chem. 272 1997 19738 19745
22. E. Giraudo, L. Primo, E. Audero, H.P. Gerber, P. Koolwijk, S. Soker, M. Klagsbrun, N. Ferrara, and F. Bussolino Tumor necrosis factor-alpha regulates expression of vascular endothelial growth factor receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells J. Biol. Chem. 273 1998 22128 22135
23. N. Klan, and D. Steinhilber Transient transfection of the human myeloid cell line Mono Mac 6 using electroporation Biotechniques 34 2003 142 147
24. D.J. Shapiro, P.A. Sharp, W.W. Wahli, and M.J. Keller A high-efficiency HeLa cell nuclear transcription extract DNA 7 1988 47 55
25. K.J. Serio, C.R. Hodulik, and T.D. Bigby Sp1 and Sp3 function as key regulators of leukotriene C(4) synthase gene expression in the monocyte-like cell line, THP-1 Am. J. Respir. Cell Mol. Biol. 23 2000 234 240
26. P. Bucher Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences J. Mol. Biol. 212 1990 563 578
27. G. Suske The Sp-family of transcription factors Gene 238 1999 291 300
28. D.B. Kim, and N.A. DeLuca Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection J. Virol. 76 2002 6473 6479
29. S. Dennler, S. Itoh, D. Vivien, P. tenDijke, S. Huet, and J.M. Gauthier Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene EMBO J. 17 1998 3091 3100
30. E.S. Silverman, J. Du, A.J. Williams, R. Wadgaonkar, J.M. Drazen, and T. Collins cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1) Biochem. J. 336 1998 183 189
31. O. Werz, J. Klemm, B. Samuelsson, and O. Radmark Phorbol ester upregulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human PMNL Blood 97 2001 2487 2495
32. C.J. Fry, and P.J. Farnham Context-dependent transcriptional regulation J. Biol. Chem. 274 1999 29583 29586
33. S.T. Smale, A. Jain, J. Kaufmann, K.H. Emami, K. Lo, and I.P. Garraway The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes Cold Spring Harbor Symp. Quant. Biol. 63 1998 21 31
34. G.E. Chalkley, and C.P. Verrijzer DNA binding site selection by RNA polymerase II TAFs: a TAF(II)250-TAF(II)150 complex recognizes the initiator EMBO J. 18 1999 4835 4845
35. S.R. Albright, and R. Tjian TAFs revisited: more data reveal twists and confirm old ideas Gene 242 2000 1 13
36. M.J. Cowan, X.L. Yao, R. Pawliczak, X. Huang, C. Logun, P. Madara, S. Alsaaty, T. Wu, and J.H. Shelhamer The role of TFIID, the initiator element and a novel 5′ TFIID binding site in the transcriptional control of the TATA-less human cytosolic phospholipase A2-alpha promoter Biochim. Biophys. Acta 1680 2004 145 157
37. E.S. Silverman, and T. Collins Pathways of Egr-1-mediated gene transcription in vascular biology Am. J. Pathol. 154 1999 665 670
38. E.S. Silverman, J. Du, A.J. Williams, R. Wadgaonkar, J.M. Drazen, and T. Collins cAMP-response-element-binding-protein binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1) Biochem. J. 336 1998 183 189
39. R.J. Pueringer, C.C. Bahns, and G.W. Hunninghake Alveolar macrophages have greater amounts of the enzyme 5-lipoxygenase than do monocytes J. Appl. Physiol. 73 1992 781 786
40. D.J. Grainger Transforming growth factor {beta} and atherosclerosis: so far, so good for the protective cytokine hypothesis Arterioscler. Thromb. Vasc. Biol. 24 2004 399 404
41. M.J. Coffey, S.E. Wilcoxen, S.M. Phare, R.U. Simpson, M.R. Gyetko, and M. Petersgolden Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages from 1,25-dihydroxyvitamin D-3-deficient rats Prostaglandins 48 1994 313 329
42. E. Stoyanova, A. Tesch, V.W. Armstrong, and E. Wieland Enzymatically degraded low density lipoproteins are more potent inducers of egr-1 mRNA than oxidized or native low density lipoproteins Clin. Biochem. 34 2001 483 490