The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1771, Issue 10, 2007, Pages 1271-1282

  Schnur, Nicole ^a   Seuter, Sabine ^b,d   Katryniok, Careen ^a   Rådmark, Olof ^c   Steinhilber, Dieter ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

5 lipoxygenase; Histone deacetylase inhibitor; Promoter activity; Sp1; Trichostatin A

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; BINDING PROTEIN; CALCIUM PHOSPHATE; DIAMINOPIMELIC ACID; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; HISTONE H4; LUCIFERASE; PROTEIN GC BOX; RNA POLYMERASE II; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; WESTERN BLOTTING;

ARACHIDONATE 5-LIPOXYGENASE; BASE SEQUENCE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN SYNTHESIS INHIBITORS; RNA POLYMERASE II; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR;

EID: 34848871701     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2007.08.003     Document Type: Article

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