Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3686-3692

  Skoumbourdis, Amanda P ^a   LeClair, Christopher A ^a   Stefan, Eduard ^b   Turjanski, Adrian G ^c   Maguire, William ^a   Titus, Steven A ^a   Huang, Ruili ^a   Auld, Douglas S ^a   Inglese, James ^a   Austin, Christopher P ^a   Michnick, Stephen W ^b   Xia, Menghang ^a   Thomas, Craig J ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Asthma; COPD; PDE4; PDE4 inhibitor; Triazolopyridazines; Triazolothiadiazines

Indexed keywords

3 (2,5 DIMETHOXYPHENYL) 6 [4 METHOXY 3 (TETRAHYDROFURAN 3 YLOXY)PHENYL] 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZINE; 3 (2,5 DIMETHOXYPHENYL) 6 [4 METHOXY 3 (TETRAHYDROFURAN 3 YLOXY)PHENYL][1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; PHOSPHODIESTERASE IV INHIBITOR; THIADIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; TRIAZOLOPYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CELL LINE; COMPUTER SIMULATION; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FURANS; HUMANS; PHOSPHODIESTERASE INHIBITORS; PROTEIN ISOFORMS; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; TRIAZOLES;

EID: 66349084978     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.057     Document Type: Article

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