(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2′-deoxyadenosine and 2′-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity

Journal of Medicinal Chemistry

Volumn 52, Issue 10, 2009, Pages 3397-3407

  Zhou, Shaoman ^a   Drach, John C ^b   Prichard, Mark N ^c   Zemlicka, Jiri ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 CHLORO 9 [2 [(1,2 DIHYDROXYETHYL)CYCLOPROPYLIDENE]METHYL]PURINE; 9 [2 (1,2 DIACETOXYETHYL)CYCLOPROPYLIDENE)METHYL]ADENINE; 9 [2 (1,2 DIHYDROXYETHYL)CYCLOPROPYLIDENE)METHYL]ADENINE; 9 [2 [(1,2 DIHYDROXYETHYL)CYCLOPROPYLIDENE]METHYL]ADENINE; 9 [2 [(1,2 DIHYDROXYETHYL)CYCLOPROPYLIDENE]METHYL]GUANINE; 9 [[2 (1,2 DIHYDROXYETHYL)CYCLOPROPYLIDENE]METHYL]GUANINE; ADENOSINE DEAMINASE; ANTIVIRUS AGENT; METHANOL DERIVATIVE; METHYLENECYCLOPROPYLCARBINOL; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EPSTEIN BARR VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN CYTOMEGALOVIRUS; NONHUMAN; STEREOISOMERISM;

ANIMALS; ANTIVIRAL AGENTS; CYCLOPROPANES; CYTOMEGALOVIRUS; DEOXYADENOSINES; DEOXYGUANOSINE; HERPESVIRUS 4, HUMAN; HUMANS; MICE; MUROMEGALOVIRUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66249106320     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900126v     Document Type: Article

References (35)

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