Interaction between connexin50 and mitogen-activated protein kinase signaling in lens homeostasis

Molecular Biology of the Cell

Volumn 20, Issue 10, 2009, Pages 2582-2592

  Shakespeare, Teresa I ^a   Sellitto, Caterina ^a   Li, Leping ^a   Rubinos, Clio ^b   Gong, Xiaohua ^c   Srinivas, Miduturu ^b   White, Thomas W ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 46; CONNEXIN 50; GAP JUNCTION PROTEIN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL VACUOLE; CONTROLLED STUDY; EYE DEVELOPMENT; FEMALE; GAP JUNCTION; HOMEOSTASIS; LENS; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; XENOPUS LAEVIS;

ANIMALS; ANIMALS, NEWBORN; CONNEXINS; ELECTRIC CONDUCTIVITY; EYE PROTEINS; GAP JUNCTIONS; GENE DELETION; GLUCOSE; HOMEOSTASIS; LENS, CRYSTALLINE; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MITOSIS; OOCYTES; PROTEIN BINDING; RECEPTORS, FIBROBLAST GROWTH FACTOR; RUPTURE, SPONTANEOUS; TRANSGENES; XENOPUS;

MUS MUSCULUS; XENOPUS LAEVIS;

EID: 66249096737     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-12-1257     Document Type: Article

References (38)

1. Bai, D., Del Corsso, C., Srinivas, M., and Spray, D. C. (2006). Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J. Pharmacol. Exp. Ther. 319, 1452-1458.
2. Baldo, G. J., and Mathias, R. T. (1992). Spatial variations in membrane properties in the intact rat lens. Biophys. J. 63, 518-529.
3. Beyer, E. C., Kistler, J., Paul, D. L., and Goodenough, D. A. (1989). Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J. Cell Biol. 108, 595-605. (Pubitemid 19065855)
4. Boswell, B. A., Lein, P. J., and Musil, L. S. (2008a). Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol. Biol. Cell 19, 2631-2641.
5. Boswell, B. A., Overbeek, P. A., and Musil, L. S. (2008b). Essential role of BMPs in FGF-induced secondary lens fiber differentiation. Dev. Biol. 324, 202-212. (Pubitemid 50313279)
6. Candia, O. A., and Zamudio, A. C. (2002). Regional distribution of the Na(+) and K(+) currents around the crystalline lens of rabbit. Am. J. Physiol. Cell Physiol. 282, C252-C262. (Pubitemid 34663184)
7. Cruikshank, S. J., Hopperstad, M., Younger, M., Connors, B. W., Spray, D. C., and Srinivas, M. (2004). Potent block of Cx36 and Cx50 gap junction channels by mefloquine. Proc. Natl. Acad. Sci. USA 101, 12364-12369. (Pubitemid 39145449)
8. Donaldson, P., Kistler, J., and Mathias, R. T. (2001). Molecular solutions to mammalian lens transparency. News Physiol. Sci. 16, 118-123. (Pubitemid 33570299)
9. Gao, J., Sun, X., Yatsula, V., Wymore, R. S., and Mathias, R. T. (2000). Isoform-specific function and distribution of Na/K pumps in the frog lens epithelium. J. Membr. Biol. 178, 89-101.
10. Gerido, D. A., and White, T. W. (2004). Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta 1662, 159-170.
11. Gong, X., Cheng, C., and Xia, C. H. (2007). Connexins in lens development and cataractogenesis. J. Membr. Biol. 218, 9-12. (Pubitemid 350132118)
12. Gong, X., Li, E., Klier, G., Huang, Q., Wu, Y., Lei, H., Kumar, N. M., Horwitz, J., and Gilula, N. B. (1997). Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell 91, 833-843. (Pubitemid 28007739)
13. Gong, X., Wang, X., Han, J., Niesman, I., Huang, Q., and Horwitz, J. (2001). Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Invest. Ophthalmol. Vis. Sci. 42, 539-548. (Pubitemid 32206888)
14. Goodenough, D. A. (1992). The crystalline lens. A system networked by gap junctional intercellular communication. Semin. Cell Biol. 3, 49-58.
15. Le, A. C., and Musil, L. S. (2001). A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediated intercellular communication in the lens. J. Cell Biol. 154, 197-216. (Pubitemid 34289289)
16. Lovicu, F. J. and McAvoy, J. W. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development 128, 5075-5084. (Pubitemid 34083034)
17. Lovicu, F. J., and McAvoy, J. W. (2005). Growth factor regulation of lens development. Dev. Biol. 280, 1-14. (Pubitemid 40342737)
18. Martinez-Wittinghan, F. J., Sellitto, C., Li, L., Gong, X., Brink, P. R., Mathias, R. T., and White, T. W. (2003). Dominant cataracts result from incongruous mixing of wild-type lens connexins. J. Cell Biol. 161, 969-978. (Pubitemid 36718429)
19. Mathias, R. T., Kistler, J., and Donaldson, P. (2007). The lens circulation. J. Membr. Biol. 216, 1-16. (Pubitemid 350194810)
20. Mathias, R. T., Rae, J. L., and Baldo, G. J. (1997). Physiological properties of the normal lens. Physiol. Rev. 77, 21-50. (Pubitemid 27068801)
21. Moreno, A. P., and Lau, A. F. (2007). Gap junction channel gating modulated through protein phosphorylation. Prog. Biophys. Mol. Biol. 94, 107-119. (Pubitemid 46782982)
22. Musil, L. S., Beyer, E. C., and Goodenough, D. A. (1990). Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation. J. Membr. Biol. 116, 163-175. (Pubitemid 20209300)
23. Paul, D. L., Ebihara, L., Takemoto, L. J., Swenson, K. I., and Goodenough, D. A. (1991). Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J. Cell Biol. 115, 1077-1089. (Pubitemid 21909955)
24. Piatigorsky, J. (1981). Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation 19, 134-153.
25. Robinson, M. L. (2006). An essential role for FGF receptor signaling in lens development. Semin. Cell Dev. Biol. 17, 726-740. (Pubitemid 46137019)
26. Robinson, M. L., Overbeek, P. A., Verran, D. J., Grizzle, W. E., Stockard, C. R., Friesel, R., Maciag, T., and Thompson, J. A. (1995). Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice. Development 121, 505-514.
27. Rong, P., Wang, X., Niesman, I., Wu, Y., Benedetti, L. E., Dunia, I., Levy, E., and Gong, X. (2002). Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation. Development 129, 167-174.
28. Sellitto, C., Li, L., and White, T. W. (2004). Connexin50 is essential for normal postnatal lens cell proliferation. Invest. Ophthalmol. Vis. Sci. 45, 3196-3202. (Pubitemid 39121855)
29. Spray, D. C., Harris, A. L., and Bennett, M. V. (1981). Equilibrium properties of a voltage-dependent junctional conductance. J. Gen. Physiol. 77, 77-93. (Pubitemid 11179578)
30. Srinivas, M., Hopperstad, M. G., and Spray, D. C. (2001). Quinine blocks specific gap junction channel subtypes. Proc. Natl. Acad. Sci. USA 98, 10942-10947. (Pubitemid 32878723)
31. Tamiya, S., Dean, W. L., Paterson, C. A., and Delamere, N. A. (2003). Regional distribution of Na,K-ATPase activity in porcine lens epithelium. Invest. Ophthalmol. Vis. Sci. 44, 4395-4399. (Pubitemid 37186275)
32. White, T. W. (2002). Unique and redundant connexin contributions to lens development. Science 295, 319-320. (Pubitemid 34074360)
33. White, T. W., Bruzzone, R., Goodenough, D. A., and Paul, D. L. (1992). Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol. Biol. Cell 3, 711-720. (Pubitemid 23084555)
34. White, T. W., Gao, Y., Li, L., Sellitto, C., and Srinivas, M. (2007). Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling. Invest Ophthalmol. Vis. Sci. 48, 5630-5637.
35. White, T. W., Goodenough, D. A., and Paul, D. L. (1998). Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J. Cell Biol. 143, 815-825. (Pubitemid 28512573)
36. Xia, C. H., Liu, H., Cheung, D., Cheng, C., Wang, E., Du, X., Beutler, B., Lo, W. K., and Gong, X. (2006). Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development 133, 2033-2040. (Pubitemid 43881268)
37. Xie, L., Overbeek, P. A., and Reneker, L. W. (2006). Ras signaling is essential for lens cell proliferation and lens growth during development. Dev. Biol. 298, 403-414. (Pubitemid 44468060)
38. Zhao, H., et al. (2008). Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev. Biol. 318, 276-288.