Investigations into the development of catalytic activity in anti-acetylcholinesterase idiotypic and anti-idiotypic antibodies

Journal of Molecular Recognition

Volumn 22, Issue 3, 2009, Pages 188-196

  Johnsona, Glynis ^a   Moorea, Samuel W ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Acetylcholinesterase; Autoimmune; Catalytic antibody; Epitope analysis; Idiotypic

Indexed keywords

ACETYLCHOLINESTERASE; ANTIIDIOTYPIC ANTIBODY; CATALYTIC ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; PEPTIDE; THYROGLOBULIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; PROTEIN MICROARRAY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TORPEDO;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, CATALYTIC; ANTIBODIES, MONOCLONAL; CATALYSIS; CATALYTIC DOMAIN; EPITOPES; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN ARRAY ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; THYROGLOBULIN; TORPEDO;

EID: 66249092759     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.931     Document Type: Article

References (39)

1. Avalle B, Mistro D, Thomas D, Friboulet A. 1996. Polyclonal catalytic anti-idiotypic antibodies with a beta-lactamase activity. Ann. N.Y. Acad. Sci. 799: 172-175. (Pubitemid 27029451)
2. Barak D, Ordentlich A, Bromberg A, Kronman C, Marano D, Lazar A, Ariel N, Velan B, Shafferman A. 1995. Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite. Biochemistry 34: 15444-15452.
3. Bhakdi S, Roth M, Hugo F. 1989. Biotinylation: a simple method for labelling complement component C8 with preservation of functional activity. J. Immunol. Methods 121: 61-66. (Pubitemid 19174092)
4. Bourne Y, Taylor P, Bougis PE, Marchot P. 1999. Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in the tetrameric assembly. J. Biol. Chem. 274: 2963-2970.
5. Branduardi D, Gervasio FL, Cavalli A, Recanatini M, Parinello M. 2005. The role of the peripheral anionic site and cation-pi interactions in the ligand penetration of the human acetylcholinesterase gorge. J. Am. Chem. Soc. 127: 9147-9155. (Pubitemid 40897607)
6. Chenna R, Sugawara H, Koike T, Lopez R, Gibson TJ, Higgins DG, Thompson JD. 2003. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res. 31: 3497-3500. (Pubitemid 37442184)
7. De Ferrari GV, Canales MA, Shin I, Weiner LM, Silman I, Inestrosa NC. 2001. A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry 40: 10447-10457. (Pubitemid 32816655)
8. Doctor BP, Smyth KK, Gentry MK, Ashani Y, Christner CE, De la Hoz DM, Ogert RA, Smith SW. 1989. Proceedings of the 32nd Oholo Conference, Eilat, Israel, April, 1988. Butterworth and Co.: London Dodson G, Wlodawer A. 1998. Catalytic triads and their relatives. Trends Biochem. Sci. 23: 347-352.
9. Eastman J, Wilson EJ, Cerven? ansky C, Rosenberry TL. 1995. Fasciculin-2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation. J. Biol. Chem. 270: 19694-19701.
10. Fambrough DM, Engel AG, Rosenberry TL. 1982. Acetylcholinesterase of human erythrocytes and neuromuscular junctions: homologies revealed by monoclonal antibodies. Proc. Natl. Acad. Sci. USA 79: 1078-1082.
11. Geen J, Howells RC, Ludgate M, Hullin DA, Hogg SI. 2004. The prevalence of anti-acetylcholinesterase antibodies in autoimmune disease. Autoimmunity 37: 579-585. (Pubitemid 40378511)
12. Gentile F, Conte M, Formisano S. 2004. Thyroglobulin as an autoantigen: what can we learn about immunopathogenicity from the correlation of antigenic properties with protein structure? Immunology 112: 13-25. (Pubitemid 38609817)
13. Harlow E, Lane D. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
14. Harbor Laboratory Press, Cold Spring Harbor. Hopp TP, Woods KR. 1983. A computer program for predicting protein antigenic determinants. Mol. Immunol. 20: 483-489.
15. Johnson G, Moore SW. 1995. Anti - acetylcholinesterase antibodies display cholinesterase - like activity. Eur. J. Immunol. 25: 25029.
16. Johnson G, Moore SW. 2000. Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors. Mol. Immunol. 37: 707-719. Johnson G, Moore SW. 2002. Idiotypic mimicry of a catalytic antibody active site. Mol. Immunol. 39: 272-288.
17. Kohler H, Paul S. 1998. Superantibody activities: new players in innate and adaptive immune responses. Immunol. Today 19: 221-228. (Pubitemid 28275574)
18. Kolesnikov AV, Kozyr AV, Alexandrovna ES, Kovalewski F, Demin AV, Titov MI, Avalle B, Tramantano A, Paul S, Thomas D, Gabibov AG, Friboulet A. 2000. Enzyme mimicry by the antiidiotypic antibody approach. Proc. Natl. Acad. Sci. USA 97: 13526-13531.
19. Kozyr AV, Sashchenko LP, Kolesnikov AV, Zelenova NA, Khaidukov SV, Ignatova AN, Bobik TV, Gabibov AG, Alekbelova ZS, Suchkov SV, Gnuchev NV. 2002. Anti-DNA autoantibodies reveal toxicity to tumor cell lines. Immunol. Lett. 80: 41-47. (Pubitemid 33096314)
20. Li L, Paul S, Tyutyulkova S, Kazatchkine MD, Kaveri S. 1995. Catalytic activity of anti-thyroglobulin antibodies. J. Immunol. 154: 3328-3332.
21. Mappouras DG, Philippou G, Haralambous S, Tzartos SJ, Balafas A, Souvatzoglou A, Lymberi P. 1995. Antibodies to acetylcholinesterase cross-reacting with thryroglobulin in myasthenia gravis and Graves's disease. Clin. Exp. Immunol. 100: 336-343.
22. Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A. 1995. Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. J. Biol. Chem. 270: 2082-2091.
23. Paul S, Volle DJ, Beach CM, Johnson DR, Powell MJ, Massey RJ. 1989. Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody. Science 244: 1158-1162. (Pubitemid 19170484)
24. Pera M, Román S, Ratia M, Camps P, Mun? oz-Torrero D, Colombo L, Manzoni C, Salmona M, Badia A, Clos MV. 2006. Acetylcholinesterase triggers the aggregation of PrP 106-126. Biochem. Biophys. Res. Commun. 346: 89-94. (Pubitemid 43865971)
25. Radic Z, Taylor P. 1999. The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. Chem. Biol. Interact. 119-120: 111-117. (Pubitemid 29278544)
26. Rosenberry TL, Mallender WD, Thomas PJ, Szegletes T. 1999. A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate. Chem. Biol. Interact. 119-120: 85-97. (Pubitemid 29278542)
27. Saxena A, Hur R, Doctor BP. 1998. Allosteric control of acetylcholinesterase activity by monoclonal antibodies. Biochemistry 37: 145-154. (Pubitemid 28049116)
28. Schlessinger A, Ofran Y, Yachdav G, Rost B. 2006. Epitome: database of structure-inferred antigenic epitopes. Nucleic Acids Res. 34: D777-D780.
29. Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B. 2005. Functional requirements for the optimal catalytic configuration of the acetylcholinesterase active center. Chem. Biol. Interact. 157-158: 123-131. (Pubitemid 41757642)
30. Shi J, Radic Z, Taylor P. 2002. Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase. J. Biol. Chem. 277: 43301-43308. (Pubitemid 35285717)
31. Shoenfeld Y. 1994. Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J. 8: 1296-1301.
32. Sinohara H, Matsuura K. 2000. Catalytic activities and functional effects of Bence Jones proteins. Chem. Immunol. 77: 89-101.
33. Sorensen K, Brodbeck U, Rasmussen AG, Norgaard-Pedersen B. 1987. An inhibitory antibody to human acetylcholinesterases. Biochim. Biophys. Acta 912: 56-65. (Pubitemid 17039029)
34. Sun M, Gao QS, Paul S. 1994. Proteolytic activity of an antibody light chain. J. Immunol. 153: 5121-5126. (Pubitemid 24356142)
35. Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I. 1991. Atomic structure of acetylcholinesterase from Torpedo californica, a prototypic acetylcholine-binding protein. Science 253: 872-879.
36. Tang J, Yuan J, Hao H. 1997. Anti-acetylcholinesterase antibody in myasthenic syndrome. Chin. Med. J. 110: 698-700. (Pubitemid 127510216)
37. Thorn SW, Daniels RG, Auditor MT, Hilvert D. 1995. Large rate accelerations in antibody catalysis by strategic use of haptenic charge. Nature 373: 228-230.
38. Weetman AP, Tse CK, Randall WR, Tsim KW, Barnard EA. 1988. Acetylcholinesterase antibodies and thyroid autoimmunity. Clin. Exp. Immunol. 71: 96-99. Wolfe AD. 1989. The monoclonal antibody AE-2 modulates fetal bovine seru, acetylcholinesterase substrate hydrolysis. Biochim. Biophys. Acta 997: 232-235. (Pubitemid 18047707)
39. Wolfe AD, Chiang PR, Doctor BP, Fryar N, Rhee JP, Saeed M. 1993. Monoclonal antibody AE-2 modulates carbamate and organophosphate inhibition of fetal bovine serum acetylcholinesterase. Mol. Pharmacol. 44: 1152-1157. (Pubitemid 24008597)