Role of ROCK I/II in vascular branching

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 4, 2009, Pages

  Van Nieuw Amerongen, Geerten P ^a   Van Hinsbergh, Victor W M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; BLOOD VESSEL; CORONARY BLOOD VESSEL; EDITORIAL; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA BLOOD VESSEL;

ANIMALS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 66249089050     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00125.2009     Document Type: Editorial

References (38)

1. Arita R, Hata Y, Nakao S, Kita T, Miura M, Kawahara S, Zandi S, Almulki L, Tayyari F, Shimokawa H, Hafezi-Moghadam A, Ishibashi T. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. Diabetes 58: 215-226, 2009.
2. Belin de Chanteméle EJ, Retailleau K, Pinaud F, Vessières E, Bocquet A, Guihot AL, Lemaire B, Domenga V, Baufreton C, Loufrani L, Joutel A, Henrion D. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler Thromb Vasc Biol 28: 2216-2224, 2008.
3. Bryan BA, d'Amore PA. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell Mol Life Sci 64: 2053-2065, 2007.
4. Davis GE, Bayless KJ, Mavila A. Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices. Anat Rec 268:252-275, 2002.
5. Fischer RS, Gardel M, Ma X, Adelstein R, Waterman CM. Local cortical tension by myosin II guides 3D endothelial cell branching. Curr Biol 19: 1-6, 2009.
6. Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Rami handrail R. Syx, a RhoA guanine exchange factor, is essential for angiogenesis in vivo. Circ Res 103: 710-716, 2008.
7. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-medi- ated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci USA 105: 11305-11310, 2008.
8. Guegan F, Tatin F, Leste-Lasserre T, Drutel G, Genot E, Moreau V. p190B-RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2. J Cell Sci 121: 2054-2061, 2008.
9. Hata Y, Miura M, Nakao S, Kawahara S, Kita T, Ishibashi T. Antiangiogenic properties of fasudil, a potent Rho-kinase inhibitor. Jpn J Ophthalmol 52: 16-23, 2008.
10. Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lind- blom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalen M, Gerhardt H, Betsholtz C. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445: 776-780, 2007.
11. Hoang MV, Whelan MC, Senger DR. Rho activity critically and selectively regulates endothelial cell organization during angiogenesis. Proc Natl Acad Sci USA 101: 1874-1879, 2004.
12. Horowitz A, Simons M. Branching morphogenesis. Circ Res 103: 784-795, 2008.
13. Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Hafezi-Moghadam A, Ishibashi T. Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci USA 105: 17504-17509, 2008.
14. Koh W, Mahan RD, Davis GE. Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling. J Cell Sci 121: 989-1001, 2008.
15. Kroll J, Epting D, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, Augustin HG. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF- driven retinal neovascularisation and sprouting angiogenesis. Am J Physiol Heart Circ Physiol 296: H893-H899, 2009. doi:10.1152/ajpheart.01038.2008.
16. Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCK kinases. Genes Dev 21: 562-577, 2007.
17. Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA 104: 3219-3224, 2007.
18. Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB. Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J 26: 2262-2273, 2007.
19. Mavria G, Vercoulen Y, Yeo M, Paterson H, Karasarides M, Marais R, Bird D, Marshall CJ. ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Cancer Cell 9: 33-44, 2006.
20. Nacak TG, Alajati A, Leptien K, Fulda C, Weber H, Miki T, Czepluch FS, Waltenberger J, Wieland T, Augustin HG, Kroll J. The BTB- Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis. Circ Res 100: 1155-1163, 2007.
21. Nakajima M, Hayashi K, Katayama K, Amano Y, Egi Y, Uehata M, Goto N, Kondo T. Wf-536 prevents tumor metastasis by inhibiting both tumor motility and angiogenic actions. Eur Pharmacol 459: 113-120, 2003.
22. Pang X, Yi T, Yi Z, Cho SG, Qu W, Pinkaew D, Fujise K, Liu M. Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. Cancer Res 69: 518 -525, 2009.
23. Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ Res 91: 143-150, 2002.
24. Riento K, Ridley AJ. Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4: 446-456, 2003.
25. Rikitake Y, Liao JK. Rho GTPases, statins and nitric oxide. Circ Res 97:1232-1235, 2005.
26. Sawada K, Morishige Ki Mabuchi S, Ogata S, Kawase C, Sakata M, Kimura T. In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis. Methods Enzymol 439: 395-412, 2008.
27. Shimokawa H, Rashid M. Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci 28: 296-302, 2007.
28. Somlyo AV, Phelps C, Dipierro C, Eto M, Read P, Barrett M, Gibson JJ, Burnitz MC, Myers C, Somlyo AP. Rho kinase and matrix metal- loproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants. FASEB J 17: 223-234, 2003.
29. Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Krem- midiotis G, Vadas MA, Gamble JR. A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proc Natl Acad Sci USA 101: 12212-12217, 2004.
30. Symons M, Settleman J. Rho family GTPases: more than simple switches. Trends Cell Biol 10: 415-419, 2000.
31. Uchida S, Watanabe G, Shimada Y, Maeda M, Kawabe A, Mori A, Arii S, Uehata M, Kishimoto T, Oikawa T, Imamura M. The suppression of small GTPase rho signal transduction pathway inhibits angiogen- esis in vitro and in vivo. Biochem Biophys Res Commun 269: 633-640, 2000.
32. Van Nieuw Amerongen GP, Koolwijk P, Versteilen A, Van Hinsbergh VWM. Involvement of RhoA/Rho kinase signaling in VEGF- induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol 23: 211-217, 2003.
33. Van Nieuw Amerongen GP, Beckers CM, Achekar ID, Zeeman S, Musters RJP, Van Hinsbergh VWM. Involvement of Rho kinase in endothelial barrier maintenance. Arterioscler Thromb Vasc Biol 27: 2332-2339, 2007.
34. Varon C, Basoni C, Reuzeau E, Moreau V, Kramer I, Génot E. TGFβ1-induced aortic endothelial morphogenesis requires signaling by small GTPases Rac1 and RhoA. Exp Cell Res 312: 3604-3619, 2006.
35. Wang W, Wu F, Fang F, Tao Y, Yang L. RhoC is essential for angiogenesis induced by hepatocellular carcinoma cells via regulation of endothelial cell organization. Cancer Sci 99: 2012-2018, 2008.
36. Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15: 177-184, 2009.
37. Yin L, Morishige Ki Takahashi T, Hashimoto K, Ogata S, Tsutsumi S, Takata K, Ohta T, Kawagoe J, Takahashi K, Kurachi H. Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Mol Cancer Ther 6: 1517-1525. 2007.
38. Yoneda A, Multhaupt HA, Couchman JR. The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol 170: 443-453, 2005.