Parkinson's disease: To live or die by autophagy

Science Signaling

Volumn 2, Issue 65, 2009, Pages

  Irrcher, Isabella ^a   Park, David S ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; DJ 1 PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PHOSPHATASE; PTEN INDUCED PUTATIVE KINASE 1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN;

AUTOPHAGY; CELL SURVIVAL; ENVIRONMENTAL FACTOR; HEREDITY; NERVE CELL; NERVE DEGENERATION; NEUROMODULATION; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; BIOLOGICAL MODEL; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL SURVIVAL; HUMANS; MODELS, BIOLOGICAL; NEURONS; PARKINSON DISEASE; SIGNAL TRANSDUCTION;

EID: 66149158177     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.265pe21     Document Type: Review

References (22)

1. Q. Yang, H. She, M. Gearing, E. Colla, M. Lee, J. J. Shacka, Z. Mao, Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323, 124-127 (2009).
2. M. G. Spillantini, R. A. Crowther, R. Jakes, M. Hasegawa, M. Goedert, Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc. Natl. Acad. Sci. U.S.A. 95, 6469-6473 (1998). (Pubitemid 28249037)
3. J. L. Cummings, Understanding Parkinson disease. JAMA 281, 376-378 (1999).
4. A. E. Lang, A. M. Lozano, Parkinson's disease. Second of two parts. N. Engl. J. Med. 339, 1130-1143 (1998).
5. C. M. Tanner, R. Ottman, S. M. Goldman, J. Ellenberg, P. Chan, R. Mayeux, J. W. Langston, Parkinson disease in twins: An etiologic study. JAMA 281, 341-346 (1999). (Pubitemid 29061038)
6. P. K. Auluck, H. Y. Chan, J. Q. Trojanowski, V. M. Lee, N. M. Bonini, Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295, 865-868 (2002).
7. A. M. Cuervo, L. Stefanis, R. Fredenburg, P. T. Lansbury, D. Sulzer, Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295 (2004).
8. T. Vogiatzi, M. Xilouri, K. Vekrellis, L. Stefanis, Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 283, 23542-23556 (2008).
9. D. Narendra, A. Tanaka, D. F. Suen, R. J. Youle, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803 (2008).
10. S. Vasseur, S. Afzal, J. Tardivel-Lacombe, D. S. Park, J. L. Iovanna, T. W. Mak, DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc. Natl. Acad. Sci. U.S.A. 106, 1111-1116 (2009).
11. J. F. Dice, Chaperone-mediated autophagy. Autophagy 3, 295-299 (2007).
12. N. Mizushima, B. Levine, A. M. Cuervo, D. J. Klionsky, Autophagy fights disease through cellular self-digestion. Nature 451, 1069-1075 (2008).
13. A. M. Cuervo, Autophagy in neurons: It is not all about food. Trends Mol. Med. 12, 461-464 (2006).
14. T. Hara, K. Nakamura, M. Matsui, A. Yamamoto, Y. Nakahara, R. Suzuki-Migishima, M. Yokoyama, K. Mishima, I. Saito, H. Okano, N. Mizushima, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889 (2006).
15. M. Komatsu, S. Waguri, T. Chiba, S. Murata, J. Iwata, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami, K. Tanaka, Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884 (2006).
16. D. J. Klionsky, H. Abeliovich, P. Agostinis, D. K. Agrawal, G. Aliev, D. S. Askew, M. Baba, E. H. Baehrecke, B. A. Bahr, A. Ballabio, B. A. Bamber, D. C. Bassham, E. Bergamini, X. Bi, M. Biard-Piechaczyk, J. S. Blum, D. E. Bredesen, J. L. Brodsky, J. H. Brumell, U. T. Brunk, W. Bursch, N. Camougrand, E. Cebollero, F. Cecconi, Y. Chen, L. S. Chin, A. Choi, C. T. Chu, J. Chung, P. G. Clarke, R. S. Clark, S. G. Clarke, C. Clave, J. L. Cleveland, P. Codogno, M. I. Colombo, A. Coto-Montes, J. M. Cregg, A. M. Cuervo, J. Debnath, F. Demarchi, P. B. Dennis, P. A. Dennis, V. Deretic, R. J. Devenish, F. Di Sano, J. F. Dice, M. Difiglia, S. Dinesh-Kumar, C. W. Distelhorst, M. Djavaheri-Mergny, F. C. Dorsey, W. Droge, M. Dron, W. A. Dunn, Jr., M. Duszenko, N. T. Eissa, Z. Elazar, A. Esclatine, E. L. Eskelinen, L. Fesus, K. D. Finley, J. M. Fuentes, J. Fueyo, K. Fujisaki, B. Galliot, F. B. Gao, D. A. Gewirtz, S. B. Gibson, A. Gohla, A. L. Goldberg, R. Gonzalez, C. Gonzalez-Estevez, S.Gorski, R. A. Gottlieb, D. Haussinger, Y. W. He, K. Heidenreich, J. A. Hill, M. Hoyer-Hansen, X. Hu, W. P. Huang, A. Iwasaki, M. Jaattela, W. T. Jackson, X. Jiang, S. Jin, T. Johansen, J. U. Jung, M. Kadowaki, C. Kang, A. Kelekar, D. H. Kessel, J. A. Kiel, H. P. Kim, A. Kimchi, T. J. Kinsella, K. Kiselyov, K. Kitamoto, E. Knecht, M. Komatsu, E. Kominami, S. Kondo, A. L. Kovacs, G. Kroemer, C. Y. Kuan, R. Kumar, M. Kundu, J. Landry, M. Laporte, W. Le, H. Y. Lei, M. J. Lenardo, B. Levine, A. Lieberman, K. L. Lim, F. C. Lin, W. Liou, L. F. Liu, G. Lopez-Berestein, C. Lopez-Otin, B. Lu, K. F. Macleod, W. Malorni, W. Martinet, K. Matsuoka, J. Mautner, A. J. Meijer, A. Melendez, P. Michels, G. Miotto, W. P. Mistiaen, N. Mizushima, B. Mograbi, I. Monastyrska, M. N. Moore, P. I. Moreira, Y. Moriyasu, T. Motyl, C. Munz, L. O. Murphy, N. I. Naqvi, T. P. Neufeld, I. Nishino, R. A. Nixon, T. Noda, B. Nurnberg, M. Ogawa, N. L. Oleinick, L. J. Olsen, B. Ozpolat, S. Paglin, G. E. Palmer, I. Papassideri, M. Parkes, D. H. Perlmutter, G. Perry, M. PiacentiniR. Pinkas-Kramarski, M. Prescott, T. Proikas-Cezanne, N. Raben, A. Rami, F. Reggiori, B. Rohrer, D. C. Rubinsztein, K. M. Ryan, J. Sadoshima, H. Sakagami, Y. Sakai, M. Sandri, C. Sasakawa, M. Sass, C. Schneider, P. O. Seglen, O. Seleverstov, J. Settleman, J. J. Shacka, I. M. Shapiro, A. Sibirny, E. C. Silva-Zacarin, H. U. Simon, C. Simone, A. Simonsen, M. A. Smith, K. Spanel-Borowski, V. Srinivas, M. Steeves, H. Stenmark, P. E. Stromhaug, C. S. Subauste, S. Sugimoto, D. Sulzer, T. Suzuki, M. S. Swanson, I. Tabas, F. Takeshita, N. J. Talbot, Z. Talloczy, K. Tanaka, K. Tanaka, I. Tanida, G. S. Taylor, J. P. Taylor, A. Terman, G. Tettamanti, C. B. Thompson, M. Thumm, A. M. Tolkovsky, S. A. Tooze, R. Truant, L. V. Tumanovska, Y. Uchiyama, T. Ueno, N. L. Uzcategui, I. van der Klei, E. C. Vaquero, T. Vellai, M. W. Vogel, H. G. Wang, P. Webster, J. W. Wiley, Z. Xi, G. Xiao, J. Yahalom, J. M. Yang, G. Yap, X. M. Yin, T. Yoshimori, L. Yu, Z. Yue, M. Yuzaki, O. Zabirnyk, X. Zheng, X. Zhu, R. L. Deter, Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-175 (2008).
17. Z. Mao, A. Bonni, F. Xia, M. Nadal-Vicens, M. E. Greenberg, Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286, 785-790 (1999).
18. P. D. Smith, M. P. Mount, R. Shree, S. Callaghan, R. S. Slack, H. Anisman, I. Vincent, X. Wang, Z. Mao, D. S. Park, Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J. Neurosci. 26, 440-447 (2006).
19. X. Tang, X. Wang, X. Gong, M. Tong, D. Park, Z. Xia, Z. Mao, Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J. Neurosci. 25, 4823-4834 (2005).
20. J. L. Webb, B. Ravikumar, J. Atkins, J. N. Skepper, D. C. Rubinsztein, Alpha-Synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 278, 25009-25013 (2003).
21. C. Zhang, A. M. Cuervo, Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat. Med. 14, 959-965 (2008).
22. I.I. is funded by a CIHR (Canadian Institute of Health Research) postdoctoral fellowship. D.S.P. is funded by grants from CIHR, Heart and Stroke Foundation of Ontario, Parkinson's Disease Foundation, Parkinson's Society Canada, the Parkinson's Research Consortium, and Brain Repair Grant from Neuroscience Canada.