Alteration of serotonin 2C receptor expression in the aorta and the pulmonary artery in rats exposed to hypoxia

Chinese Journal of Physiology

Volumn 51, Issue 6, 2008, Pages 338-347

  Zhang, Bo ^a   Liu, Yi ^a   Luo, Ying ^a   Niu, Wen ^a   Li, Zhi Chao ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Aorta; Hypoxia; Pulmonary artery; Receptor; Serotonin

Indexed keywords

SEROTONIN 2C RECEPTOR; SMALL INTERFERING RNA; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; AORTIC SMOOTH MUSCLE CELL; ARTERIAL WALL THICKNESS; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HYPOXIA; HYPOXIC PULMONARY HYPERTENSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PULMONARY ARTERIAL SMOOTH MUSCLE CELL; PULMONARY ARTERY; PULMONARY HYPERTENSION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; ANOXIA; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; AORTA; CELLS, CULTURED; GENE EXPRESSION REGULATION; MALE; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RNA, MESSENGER;

EID: 66149136473     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Bialecki, R.A., Fisher, C.S., Murdoch, W.W., Barthlow, H.G., Stow, R.B., Mallamaci, M. and Rumsey, W. Hypoxic exposure time dependently modulates endothelin-induced contraction of pulmonary artery smooth muscle. Am. J. Physiol. 274: L552-L559, 1998.
2. Bubar, M.J., Seitz, P.K., Thomas, M.L., and Cunningham, K.A. Validation of a selective serotonin 5-HT2C receptor antibody for utilization in fluorescence immunohistochemistry studies. Brain. Res. 1063: 105-113, 2005.
3. Burns, C.M., Chu, H., Rueter, S.M., Hutchinson, L.K., Canton, H., Sanders-Bush, E. and Emeson, R.B. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387: 303-308, 1997.
4. Calama, E., Moran, A., Ortiz de Urbina, A.V., Martin, M.L. and San Roman, L. Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats. Pharmacology 71: 66-72, 2004.
5. Canton, H., Emeson, R.B., Barker, E.L., Backstrom, J.R., Lu, J.T., Chang, M.S. and Sanders-Bush, E. Identification, molecular cloning and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Mol. Pharmacol. 50: 799-807, 1996.
6. Chamley-Campbell, J., Camplell, G.R. and Ross, R. The smooth muscle cell in culture. Physiol. Rev. 59: 1-61, 1979.
7. Dumas, J.P., Bardou, M., Goirand, F. and Dumas, M. Hypoxic pulmonary vasoconstriction. Gen. Pharmacol. 33: 289-297, 1999.
8. Fernandez, M.M., Moran, A., Martin, M.L. and San Roman, L. Mesenteric vasoconstrictor response to 5-hydroxytryptamine in the in situ blood autoperfused rat mesentery: involvement of 5-HT2B and/or 5-HT2C receptor activation. Eur. J. Pharmacol. 401: 221-227, 2000.
9. Humphrey, P.P., Hartig, P. and Hoyer, D. A proposed new nomenclature for 5-HT receptors. Trends. Pharmacol. Sci. 14: 233-236, 1993.
10. Iwamoto, K., Nakatani, N., Bundo, M., Yoshikawa, T. and Kato, T. Altered RNA editing of serotonin 2C receptor in a rat model of depression. Neurosci. Res. 53: 69-76, 2005.
11. Jeffery, T.K. and Morrell, N.W. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog. Cardiovasc. Dis. 45: 173-202, 2002.
12. Julius, D., Livelli, T.J., Jessell, T.M. and Axel, R. Ectopic expression of the serotonin lc receptor and the triggering of malignant transformation. Science 244: l057-1062, 1989.
13. Keegan, A., Morecroft, I., Smillie, D., Hicks, M.N. and MacLean, M.R. Contribution of the 5-HT1B receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT1B-receptor knockout mice and the 5-HT1B/1D-receptor antagonist GR127935. Circ. Res. 89: 1231-1239, 2001.
14. Keegan, L.P., Gallo, A., O'Connell, M.A. The many roles of an RNA editor. Nat. Rev. Genet. 2: 869-878, 2001.
15. Kereveur, A., Callebert, J., Humbert, M., Herve, P., Simonneau, G. and Launay, J.M. High plasma serotonin levels in primary pulmonary hypertension:effect of long-term epoprostenol (Prostacyclin) therapy. Arterioscler. Thromb. Vasc. Biol. 20: 2233-2239, 2000.
16. Lai, Y.L., Chen, C.F., Chien, C.T., Shiao, H.L., Thacker, A.A. and Zhang, H.Q. Capsaicin pretreatment attenuates chronic hypoxic pulmonary hypertension. Respir. Physiol. 99: 283-289, 1995.
17. Launay, J.M., Herve, P., Peoc'h, K., Tournois, C., Callebert, J., Nebigil, C.G., Etienne, N., Drouet, L., Humbert, M., Simonneau, G. and Maroteaux, L. Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat. Med. 8: 1129-1135, 2002.
18. Liao, X., Tang, S., Thrasher, J.B., Griebling, T.L. and Li, B. Smallinterfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol. Cancer. Ther. 4: 505-515, 2005.
19. Livak, K.J. and Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods 25: 402-408, 2001.
20. Li, Z.C., Zhang, F.Q., Song, J.C., Mei, Q.B. and Zhao, D.H. Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat. J. Appl. Physiol. 92: 997-1003, 2002.
21. Maclean, M.R., Herve, P., Eddahibi, S. and Adnot, S. 5-Hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Brit. J. Pharmacol. 131: 161-168, 2000.
22. MacLean, M.R., Sweeney, G., Baird, M., McCulloch, K.M., Houslay, M. and Morecroft, I. 5 -Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Brit. J. Pharmacol. 119: 917-930, 1996.
23. Marcos, E., Fadel, E., Sanchez, O., Humbert, M., Dartevelle, P., Simonneau, G., Hamon, M., Adnot, S. and Eddahibi, S. Serotonininduced smooth muscle hyperplasia in various forms of human pulmonary hypertension. Circ. Res. 94: 1263-1270, 2004.
24. Ogretmen, B. and Safa, A.R. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistan MCF-7/Adr human breast cancer cells. Oncogene 14: 499-506, 1997.
25. Pitt, B.R., Weng, W., Steve, A.R., Blakely, R.D., Reynolds, I. and Davies, P. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. Am. J. Physiol. 266: L178-L186, 1994.
26. Reenan, R.A. The RNA world meets behavior: A-I pre-mRNA editing in animals. Trends Genet. 17: 53-56, 2001.
27. Sharma, S.K., Zahradka, P., Chapman, D., Kumamoto, H., Takeda, N. and Dhalla, N.S. Inhibition of serotonin-induced vascular smooth muscle cell proliferation by sarpogrelate. J. Pharmacol. Exp. Ther. 290: 1475-1481, 1999.
28. Smith, B.M., Thomsen, W.J. and Grottick, A.J. The potential use of selective 5-HT2C adonists in treating obesity. Expert. Opin. Investig. Drugs. 15: 257-266, 2006.
29. Sukma, M., Tohda, M., Watanabe, H. and Matsumoto, K. The mRNA expression differences of RNA editing enzymes in differentiated and undifferentiated NG108-15 cells. J. Pharmacol. Sci. 98: 467-470, 2005.
30. Thomas, B.J. and Wanstall, J.C. Alterations in pulmonary vascular function in rats exposed to intermittent hypoxia. Eur. J. Pharmacol. 477: 153-161, 2003.
31. Tohda, M., Nomura, M. and Nomura, Y. Molecular pathopharmacology of 5-HT2C receptors and the RNA editing in the brain. J. Pharmacol. Sci. 100: 427-432, 2006.
32. Ullmer, C., Schmuck, K., Kalkman, H.O. and Lubbert, H. Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 370: 215-221, 1995.
33. Von Euler, U.S., and Liljestrand, G. Observations on the pulmonary arterial blood pressure in the cat. Acta. Physiol. Scand. 12: 301-320, 1946.
34. Wang, D., Post, M. and Cutz, E. Expression of serotonin receptor 2C in rat type II pneumocytes. Am. J. Resp. Cell. Mol. 20: 1175-1180, 1999.
35. Wang, Q., O'Brien, P.J., Chen, C.X., Cho, D.S., Murray, J.M. and Nishikura, K. Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin-2c receptors. J. Neurochem. 74: 1290-1300, 2000.
36. Wanstall, J.C. and O'Donnell, S.R. Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension. Eur. J. Pharmacol. 176: 159-168, 1990.
37. Wanstall, J.C. and O'Donnell, S.R. Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats. Brit. J. Pharmacol. 105: 152-158, 1992.
38. Welsh, D.J., Scott, P., Plevin, R., Wadsworth, R. and Peacock, A.J. Hypoxia enhances cellular proliferation and inositol 1,4,5-triphosphate generation in fibroblasts from bovine the pulmonary artery but not from mesenteric artery. Am. J. Resp. Crit. Care. 158: 1757-1762, 1998.
39. Xie, E., Zhu, L., Zhao, L. and Chang, L.S. The human serotonin 5- HT2C receptor: complete cDNA, genomic structure and alternatively spliced variant. Genomics 35: 551-561, 1996.
40. Zamore, P.D. RNA interference: listening to the sound of silence. Nat. Struct. Biol. 8: 746-750, 2001.