Signal transduction molecules as targets for cancer prevention

Science Signaling

Volumn 2, Issue 59, 2009, Pages

  Bode, Ann M ^a   Dong, Zigang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; SIGNAL PEPTIDE;

APOPTOSIS; CANCER PREVENTION; CARCINOGENESIS; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL SURVIVAL; CONFERENCE PAPER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ARTICLE; DRUG DEVELOPMENT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; NEOPLASM; PHYSIOLOGY;

DRUG DISCOVERY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 66149113319     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.259mr2     Document Type: Conference Paper

References (54)

1. 2-kinase 1 signaling and H-Ras-induced cell transformation. Cancer Res.67, 5186-5194 (2007). (Pubitemid 46997256)
2. T. A. Zykova, F. Zhu, C. Lu, L. Higgins, Y. Tatsumi, Y. Abe, A. M. Bode, Z. Dong, Lymphokine-activated killer T-cell-originated protein kinase phosphoryla-tion of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. Clin. Cancer Res.12, 6884-6893 (2006). (Pubitemid 44974480)
3. F. Zhu, T. A. Zykova, B. S. Kang, Z. Wang, M. C. Ebeling, Y. Abe, W.Y. Ma, A. M. Bode, Z. Dong, Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Gastroenterology 133, 219-231 (2007). (Pubitemid 47031135)
4. D. Zheng, A. M. Bode, Q. Zhao, Y. Y. Cho, F. Zhu, W. Y. Ma, Z. Dong, The cannabinoid receptors are required for ultraviolet-induced inflammation and skin cancer development. Cancer Res. 68, 3992-3998 (2008).
5. C. Segrelles, J. Lu, B. Hammann, M. Santos, M. Moral, J. L. Cascallana, M. F. Lara, O. Rho, S. Car-bajal, J. Traag, L. Beltran, A. B. Martinez-Cruz, R. Garcia-Escudero, C. Lorz, S. Ruiz, A. Bravo, J. M. Paramio, J. DiGiovanni, Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res. 67, 10879-10888 (2007). (Pubitemid 350145917)
6. J. Lu, O. Rho, E. Wilker, L. Beltran, J. Digiovanni, Activation of epidermal akt by diverse mouse skin tumor promoters. Mol. Cancer Res. 5, 1342-1352 (2007).
7. J. Zhang, G. T. Bowden, UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. Mol. Carcinog. 47, 974-983 (2008).
8. C. P. Matthews, A. M. Birkholz, A. R. Baker, C. M. Perella, G. R. Beck Jr., M. R.Young, N. H. Colburn, Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis. Cancer Res. 67, 2430-2438 (2007).
9. N. LaRonde-LeBlanc, A. N. Santhanam, A. R. Baker, A. Wlodawer, N. H. Colburn, Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol. Cell. Biol. 27, 147-156 (2007). (Pubitemid 46013240)
10. S. M. Fischer, A. Pavone, C. Mikulec, R. Langen-bach, J. E. Rundhaug, Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol. Carcinog. 46, 363-371 (2007). (Pubitemid 46744456)
11. J. E. Rundhaug, S. M. Fischer, Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem. Photobiol. 84, 322-329 (2008).
12. J. E. Rundhaug, A. Pavone, E. Kim, S. M. Fischer, The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent. Mol. Carcinog. 46, 981-992 (2007). (Pubitemid 350234255)
13. A. B. Glick, R. Perez-Lorenzo, J. Mohammed, Context-dependent regulation of cutaneous immunological responses by TGF|31 and its role in skin carcinogenesis. Carcinogenesis 29, 9-14 (2008). (Pubitemid 351201736)
14. S. Bornstein, K. Hoot, G. W. Han, S. L. Lu, X. J. Wang, Distinct roles of individual Smads in skin carcinogenesis. Mol. Carcinog. 46, 660-664 (2007). (Pubitemid 47255184)
15. P. Owens, G. Han, A. G. Li, X. J. Wang, The role of Smads in skin development. J. Invest. Dermatol. 128, 783-790 (2008). (Pubitemid 351374283)
16. A. Bhoumik, Z. Ronai, ATF2: A transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle 7, 2341-2345 (2008).
17. Q. Gu, G. T. Bowden, D. Normolle, Y. Sun, SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IKB-(X/NF-KB. J. Cell Biol. 178, 1009-1023 (2007). (Pubitemid 47443323)
18. A. M. D'Costa, J. K. Robinson, T. Maududi, V. Chaturvedi, B. J. Nickoloff, M. F. Denning, The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene 25, 378-386 (2006). (Pubitemid 43117623)
19. M. H. Aziz, H. T. Manoharan, A. K. Verma, Protein kinase C e, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with Stat3. Cancer Res. 67, 1385-1394 (2007). (Pubitemid 46270800)
20. D. Chebotaev, A. Yemelyanov, L. Zhu, R. M. Lavker, I. Budunova, The tumor suppressor effect of the glucocorticoid receptor in skin is mediated via its effect on follicular epithelial stem cells. Oncogene 26, 3060-3068 (2007). (Pubitemid 46733642)
21. D. Pei, The magic continues for the iPS strategy. Cell Res. 18, 221-223 (2008). (Pubitemid 351206158)
22. R. J. Morris, Stem cells in the hair follicle and inter-follicular epidermis of mice following topical application of fluocinolone acetonide. J. Invest. Dermatol. 127, 2707-2708 (2007).
23. J. Xie, Hedgehog signaling pathway: Development of antagonists for cancer therapy. Curr. Oncol. Rep. 10, 107-113 (2008). (Pubitemid 351395470)
24. Y. J. Surh, H. K. Na, NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cyto-protection with anti-inflammatory and antioxidant phytochemicals. Genes Nutr.2, 313-317 (2008).
25. B. Rigas, J. L. Williams, NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action. Nitric Oxide 19, 199-204 (2008).
26. L. Li, L. Guo, Y. Tao, S. Zhou, Z. Wang, W. Luo, D. Hu, Z. Li, L. Xiao, M. Tang, W.Yi, S. W. Tsao, Y. Cao, Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinas-es. Cancer Lett.255, 219-231 (2007). (Pubitemid 47271954)
27. Y. P. Liu, Y. N. Tan, Z. L. Wang, L. Zeng, Z. X. Lu, L. L. Li, W. Luo, M. Tang, Y. Cao, Phosphorylation and nuclear translocation of STAT3 regulated by the Ep-stein-Barr virus latent membrane protein 1 in na-sopharyngeal carcinoma. Int. J. Mol. Med.21, 153-162 (2008). (Pubitemid 351222848)
28. A. H. Conney, S. Zhou, M. J. Lee, J. G. Xie, C. S. Yang, Y. R. Lou, Y. Lu, Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-in-duced apoptosis in the epidermis of SKH-1 mice. Toxicol.Appl. Pharmacol.224, 209-213 (2007). (Pubitemid 47592857)
29. X. Zheng, X. X. Cui, M. T. Huang, Y. Liu, W. J. Shih, Y. Lin, Y. P. Lu, G. C. Wagner, A. H. Conney, Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient mice. Oncol.Rep.19, 1583-1588 (2008).
30. M. J. Bonorden, O. P. Rogozina, C. M. Kluczny, M. E. Grossmann, J. P. Grande, A. Lokshin, M. P. Cleary, Cross-sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouse. Prostate69, 317-326 (2008).
31. A. J. McMichael, Food, nutrition, physical activity and cancer prevention. Authoritative report from World Cancer Research Fund provides global update. Public Health Nutr.11, 762-763 (2008). (Pubitemid 351787045)
32. W. K. Hong, General keynote: The impact of cancer chemoprevention. Gynecol. Oncol. 88, S56-S58 (2003).
33. S. P. Ermakova, B. S. Kang, B. Y. Choi, H. S. Choi, T. F. Schuster, W. Y. Ma, A. M. Bode, Z. Dong, (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. Cancer Res.66, 9260-9269 (2006). (Pubitemid 44521148)
34. H. Xiao, X. Hao, B. Simi, J. Ju, H. Jiang, B. S. Red-dy, C. S. Yang, Green tea polyphenols inhibit col-orectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis 29, 113-119 (2008). (Pubitemid 351201749)
35. Y. Y. Cho, K. Yao, H. G. Kim, B. S. Kang, D. Zheng, A. M. Bode, Z. Dong, Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res.67, 8104-8112 (2007). (Pubitemid 47395145)
36. A. O. Abu-Yousif, K. A. Smith, S. Getsios, K. J. Green, R. T. Van Dross, J. C. Pelling, Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Cancer Res.68, 3057-3065 (2008). (Pubitemid 351556308)
37. M. Gu, R. P. Singh, S. Dhanalakshmi, C. Agarwal, R. Agarwal, Silibinin inhibits inflammatory and an-giogenic attributes in photocarcinogenesis in SKH-1 hairless mice. Cancer Res. 67, 3483-3491 (2007). (Pubitemid 46724890)
38. K. Ramasamy, R. Agarwal, Multitargeted therapy of cancer by silymarin. Cancer Lett. 269, 352-362 (2008).
39. C. V. Rao, Regulation of COX and LOX by curcum-in. Adv. Exp. Med. Biol.595, 213-226 (2007).
40. S. S. Hecht, Progress and challenges in selected areas of tobacco carcinogenesis. Chem. Res. Toxicol.21, 160-171 (2008).
41. J. Guo, C. Jiang, Z. Wang, H. J. Lee, H. Hu, B. Malewicz, J. H. Lee, N. I. Baek, J. H. Jeong, D. K. Kim, K. S. Kang, S. H. Kim, J. Lu, A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol. Cancer Ther.6, 907-917 (2007). (Pubitemid 46554560)
42. A.Yemelyanov, J. Czwornog, L. Gera, S. Joshi, R. T. Chatterton Jr., I. Budunova, Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells. Cancer Res. 68, 4763-4773 (2008).
43. U.S. Food and Drug Administration, Center for Drug Evaluation and Research, "Guidance for industry, investigators, and reviewers. Exploratory IND studies" (U.S. Department of Health and Human Services, Washington, DC, 2006).
44. J. H. Doroshow, R. E. Parchment, Oncologic phase 0 trials incorporating clinical pharmacodynamics: From concept to patient. Clin. Cancer Res. 14, 3658-3663 (2008).
45. S. Kummar, L. Rubinstein, R. Kinders, R. E. Parchment, M. E. Gutierrez, A. J. Murgo, J. Ji, B. Mroczkowski, O. K. Pickeral, M. Simpson, M. Hollingshead, S. X. Yang, L. Helman, R. Wiltrout, J. Collins, J. E. Tomaszewski, J. H. Doroshow, Phase 0 clinical trials: Conceptions and misconceptions. Cancer J.14, 133-137 (2008).
46. B. S. Shumway, L. A. Kresty, P. E. Larsen, J. C. Zwick, B. Lu, H. W. Fields, R. J. Mumper, G. D. Ston-er, S. R. Mallery, Effects of a topically applied bioad-hesive berry gel on loss of heterozygosity indices in premalignant oral lesions. Clin. Cancer Res. 14, 2421-2430 (2008). (Pubitemid 351551076)
47. B. Y. Choi, H. S. Choi, K. Ko, Y. Y. Cho, F. Zhu, B. S. Kang, S. P. Ermakova, W. Y. Ma, A. M. Bode, Z. Dong, The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phos-phorylation and AP-1 activity. Nat. Struct. Mol. Biol. 12, 699-707 (2005). (Pubitemid 43086276)
48. K. W. Lee, N. J. Kang, Y. S. Heo, E. A. Rogozin, A. Pugliese, M. K. Hwang, G. T. Bowden, A. M. Bode, H. J. Lee, Z. Dong, Raf and MEK protein kinases are direct molecular targets for the chemopreven-tive effect of quercetin, a major flavonol in red wine. Cancer Res.68, 946-955 (2008). (Pubitemid 351206774)
49. K. W. Lee, N. J. Kang, E. A. Rogozin, S. M. Oh, Y. S. Heo, A. Pugliese, A. M. Bode, H. J. Lee, Z. Dong, The resveratrol analogue 3,5,3′,4', 5′-pentahydroxy-trans-stilbene inhibits cell transformation via MEK. Int. J. Cancer123, 2487-2496 (2008).
50. M. Li, Z. He, S. Ermakova, D. Zheng, F. Tang, Y. Y. Cho, F. Zhu, W.Y. Ma, Y. Sham, E. A. Rogozin, A. M. Bode, Y. Cao, Z. Dong, Direct inhibition of insulinlike growth factor-I receptor kinase activity by (-)-epigallocatechin-3- gallate regulates cell transformation. Cancer Epidemiol. Biomarkers Prev. 16, 598-605 (2007). (Pubitemid 46548666)
51. J. H. Shim, H. S. Choi, A. Pugliese, S. Y. Lee, J. I. Chae, B. Y. Choi, A. M. Bode, Z. Dong, (-)-Epigallo-catechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase. J. Biol. Chem. 283, 28370-28379 (2008).
52. Y.-P. Pang, A. Vummenthala, J. G. Park, S.-H. Wang, Z. Dong, A. M. Bode, Y.-Y. Cho, U.S. provisional patent application 61/102,089 (2008).
53. S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, C. MacAulay, In vivo optical coherence tomography imaging of preinvasive bronchial lesions. Clin. Cancer Res.14, 2006-2011 (2008). (Pubitemid 351551109)
54. T. Hompland, A. Erikson, M. Lindgren, T. Lindmo, C. de Lange Davies, Second-harmonic generation in collagen as a potential cancer diagnostic parameter. J. Biomed. Opt.13, 054050 (2008).