Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient mice

Oncology Reports

Volumn 19, Issue 6, 2008, Pages 1583-1588

  Zheng, Xi ^a   Cui, Xiao Xing ^a   Huang, Mou Tuan ^a   Liu, Yue ^a   Shih, Weichung Joe ^b,c   Lin, Yong ^b,c   Lu, Yao Ping ^a   Wagner, George C ^a   Conney, Allan H ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Apoptosis; Cancer growth; Cancer prevention; Exercise; Mitosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIPID COMPOSITION; MALE; MITOSIS; MOUSE; NONHUMAN; PANCREAS CANCER; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROSTATE CANCER; SCID MOUSE; SEVERE COMBINED IMMUNODEFICIENCY; TREADMILL EXERCISE; TREATMENT RESPONSE; TUMOR VOLUME; TUMOR XENOGRAFT; VOLUNTARY MOVEMENT; ANIMAL; CELL CULTURE; DRUG SCREENING; METABOLISM; MITOSIS INDEX; MOTOR ACTIVITY; MOUSE MUTANT; PANCREAS TUMOR; PATHOLOGY; PROSTATE TUMOR;

CASPASE 3;

ANIMALS; CASPASE 3; CELL PROLIFERATION; FEMALE; HUMANS; MALE; MICE; MICE, SCID; MITOTIC INDEX; MOTOR ACTIVITY; PANCREATIC NEOPLASMS; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 48849104456     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 57: 43-66, 2007.
2. Reddy BS, Sugie S and Lowenfels A: Effect of voluntary exercise on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res 48: 7079-7081, 1988.
3. Cohen LA, Choi K, Backlund JY, Harris R and Wang CX: Modulation of N-nitrosomethylurea induced mammary tumorigenesis by dietary fat and voluntary exercise. In Vivo 5: 333-344, 1991.
4. Thompson HJ: Effects of physical activity and exercise on experimentally-induced mammary carcinogenesis. Breast Cancer Res Treat 46: 135-141, 1997.
5. Michna L, Wagner GC, Lou YR, Xie JG, Peng QY, Lin Y, Carlson K, Shih WJ, Conney AH and Lu YP: Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 27: 2108-2115, 2006.
6. Roebuck BD, McCaffrey J and Baumgartner KJ: Protective effects of voluntary exercise during the postinitiation phase of pancreatic carcinogenesis in the rat. Cancer Res 50: 6811-6816, 1990.
7. Craven-Giles T, Tagliaferro AR, Ronan AM, Baumgartner KJ and Roebuck BD: Dietary modulation of pancreatic carcinogenesis: calories and energy expenditure. Cancer Res 54: S1964-S1968, 1994.
8. Cerhan JR, Torner JC, Lynch CF, Rubenstein LM, Lemke JH, Cohen MB, Lubaroff DM and Wallace RB: Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (USA). Cancer Causes Control 8: 229-238, 1997.
9. Wannamethee SG, Shaper AG and Walker M: Physical activity and risk of cancer in middle-aged men. Br J Cancer 85: 1311-1316, 2001.
10. Lee IM, Sesso HD, Chen JJ and Paffenbarger RS Jr: Does physical activity play a role in the prevention of prostate cancer? Epidemiol Rev 23: 132-137, 2001.
11. Friedenreich CM, McGregor SE, Courneya KS, Angyalfi SJ and Elliott FG: Case-control study of lifetime total physical activity and prostate cancer risk. Am J Epidemiol 159: 740-749, 2004.
12. Patel AV, Rodriguez C, Jacobs EJ, Solomon L, Thun MJ and Calle EE: Recreational physical activity and risk of prostate cancer in a large cohort of US men. Cancer Epidemiol Biomarkers Prev 14: 275-279, 2005.
13. Nilsen TI, Romundstad PR and Vatten LJ: Recreational physical activity and risk of prostate cancer: A prospective population-based study in Norway (the HUNT study). Int J Cancer 119: 2943-2947, 2006.
14. Leung PS, Aronson WJ, Ngo TH, Golding LA and Barnard RJ: Exercise alters the IGF axis in vivo and increases p53 protein in prostate tumor cells in vitro. J Appl Physiol 96: 450-454, 2004.
15. Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, Dunn-Emke S, Crutchfield L, Jacobs FN, Barnard RJ, Aronson WJ, McCormac P, McKnight DJ, Fein JD, Dnistrian AM, Weinstein J, Ngo TH, Mendell NR and Carroll PR: Intensive lifestyle changes may affect the progression of prostate cancer. J Urol 174: 1065-1069, 2005.
16. Michaud DS, Giovannucci E, Willett WC, Colditz GA, Stampfer MJ and Fuchs CS: Physical activity, obesity, height and the risk of pancreatic cancer. JAMA 286: 921-929, 2001.
17. Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J and Albanes D: A prospective study of medical conditions, anthropometry, physical activity and pancreatic cancer in male smokers (Finland). Cancer Causes Control 13: 417-426, 2002.
18. Sinner PJ, Schmitz KH, Anderson KE and Folsom AR: Lack of association of physical activity and obesity with incident pancreatic cancer in elderly women. Cancer Epidemiol Biomarkers Prev 14: 1571-1573, 2005.
19. Tannapfel A, Geissler F, Kockerling F, Katalinic A, Hauss J and Wittekind C: Apoptosis and proliferation in relation to histopathological variables and prognosis in hepatocellular carcinoma. J Pathol 187: 439-445, 1999.
20. Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin Y, Reuhl K, Newmark H, Rabson A and Conney AH: Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice. Cancer Res 64: 1811-1820, 2004.
21. Lindsey JK: Models for Repeated Measurements. Claredon Press, Oxford, 1993.
22. Welsch MA, Cohen LA and Welsch CW: Inhibition of growth of human breast carcinoma xenografts by energy expenditure via voluntary exercise in athymic mice fed a high-fat diet. Nutr Cancer 23: 309-318, 1995.
23. Lu YP, Lou YR, Nolan B, Peng QY, Xie JG, Wagner GC and Conney AH: Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice. Proc Natl Acad Sci USA 103: 16301-16306, 2006.
24. Pedersen BK and Fischer CP: Beneficial health effects of exercise - the role of IL-6 as a myokine. Trends Pharmacol Sci 28: 152-156, 2007.
25. Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ and Willett WC: A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med 165: 1005-1010, 2005.