Phosphodiesterase-5 inhibitors oppose hyperoxic vasoconstriction and accelerate seizure development in rats exposed to hyperbaric oxygen

Journal of Applied Physiology

Volumn 106, Issue 4, 2009, Pages 1234-1242

  Demchenko, Ivan T ^a,b   Ruehle, Alex ^a   Allen, Barry W ^a   Vann, Richard D ^a   Piantadosi, Claude A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

Cerebral blood flow; Nitric oxide; Oxygen seizures; Phosphodiesterase 5 blockers

Indexed keywords

N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; SILDENAFIL; TADALAFIL; CYCLIC GMP; GUANYLATE CYCLASE; NEURONAL NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BRAIN BLOOD FLOW; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DRUG ANTAGONISM; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITION; HYDROGEN CLEARANCE; HYPERBARIC OXYGEN; HYPEROXIA; LATENT PERIOD; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN TENSION; OXYGEN TOXICITY; OXYGENATION; PH ELECTRODE; PRIORITY JOURNAL; RAT; SEIZURE; VALIDATION STUDY; VASOCONSTRICTION; ANESTHESIA; ANIMAL; BLOOD PRESSURE; BRAIN CIRCULATION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANESTHESIA; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; GUANYLATE CYCLASE; HYPERBARIC OXYGENATION; HYPEROXIA; INFUSIONS, INTRAVENOUS; MALE; NITRIC OXIDE SYNTHASE TYPE I; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 66149102378     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91407.2008     Document Type: Article

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