Effect of sildenafil (Viagra®) on cerebral blood flow velocity: A pilot study

Psychiatry Research - Neuroimaging

Volumn 122, Issue 3, 2003, Pages 207-209

  Arnavaz, Anouscheh ^a   Aurich, Andreas ^a   Weißenborn, Karin ^a   Hartmann, Uwe ^a   Emrich, Hinderk M ^a   Schneider, Udo ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cerebral blood flow velocity; Doppler ultrasonography; Sildenafil

Indexed keywords

SILDENAFIL;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOPPLER ECHOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEADACHE; HEMODYNAMICS; HUMAN; MALE; MEASUREMENT; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; NOSE CONGESTION; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERTIGO;

EID: 0037383775     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4927(03)00018-0     Document Type: Article

References (8)

1. Andersson K.E., Stief C.G. Neurotransmission and the contraction and relaxation of penile erectile tissues. World Journal of Urology. 15:1997;14-20.
2. Kruuse C., Rybalkin S.D., Khurana T.S., Jansen-Olesen I., Olesen J., Edvinsson L. The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation. European Journal of Pharmacology. 420:2001;55-65.
3. Langtry H.D., Markham A. Sildenafil: a review of its use in erectile dysfunction. Drugs. 57:1999;967-989.
4. Lin C.S., Lau A., Tu R., Lue T.F. Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. Biochemical and Biophysical Research Communications. 268:2000;628-635.
5. Medina P., Segarra G., Martinez-Leon J.B., Vila J.M., Aldasoro M., Otero E., Lluch S. Relaxation induced by cGMP phosphodiesterase inhibitors sildenafil and zaprinast in human vessels. Annals of Thoracic Surgery. 70:2000;1327-1331.
6. Taher A., Meyer M., Stief C.G., Jonas U., Forssmann W.G. Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle. World Journal of Urology. 15:1997;32-35.
7. Wallis, R.M., 1999. The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5. Nippon Yakurigaku Zasshi 114(Suppl 1), 22-26.
8. Willette R.N., Shiloh A.O., Sauermelch C.F., Sulpizio A., Michell M.P., Cieslinski L.B., Torphy T.J., Ohlstein E.H. Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors. Journal of Cerebral Blood Flow and Metabolism. 17:1997;210-219.