Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells

Journal of Cellular Physiology

Volumn 207, Issue 3, 2006, Pages 836-844

  Mantovani, Irina ^a   Cappellini, Alessandra ^b   Tazzari, Pier Luigi ^c   Papa, Veronica ^a   Cocco, Lucio ^a   Martelli, Alberto M ^a,d  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF CASSINO AND SOUTHERN LAZIO   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIBODY; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 6; CASPASE INHIBITOR; FAS LIGAND; GLYCOPROTEIN P; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; T LYMPHOBLAST; ULTRAVIOLET RADIATION;

APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CHROMONES; EPITOPES; HUMANS; MOLECULAR WEIGHT; MORPHOLINES; P-GLYCOPROTEIN; T-LYMPHOCYTES;

EID: 33646354397     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20628     Document Type: Article

References (34)

1. Ahmad KA, Iskandar KB, Hirpara JL, Clement MV, Pervaiz S. 2004. Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res 64: 7867-7878.
2. Borst P, Schinkel AH. 1996. What have we learnt thus far from mice with disrupted P-glycoprotein genes? Eur J Cancer 32:985-990.
3. Cenni V, Maraldi NM, Ruggeri A, Secchiero P, Del Coco R, De Pol A, Cocco L, Marmiroli S. 2004. Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. Int J Oncol 25:1599-1608.
4. Chang F, Lee JT, Navolanic PM, Shelton JG, Moye PW, Lee JT, Franklin RA, Mirza A, McMahon M, White MK, McCubrey JA. 2003. Involvement of PI3K/ Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy. Leukemia 17:590-603.
5. Chun TM, Kawinski E, Lin TH. 1993. Characterization of a new monoclonal antibody F4 detecting cell surface epitope and P-glycoprotein in drug-resistant human tumor cell lines. Hybridoma 12:417-429.
6. Clement MV, Ponton A, Pervaiz S. 1998. Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu. FEBS Lett 440:13-18.
7. Fischer U, Janicke RU, Schulze-Osthoff K. 2003. Many cuts to ruin: A comprehensive update of caspase substrates. Cell Death Differ 10:76-100.
8. Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I. 1995. Genetic analysis of the multidrug transporter. Annu Rev Genet 29:607-649.
9. Gupta S, Gollapudi S. 1993. P-glycoprotein (MDR 1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection. J Clin Immunol 13:289-301.
10. Hanada M, Feng J, Hemmings BA. 2004. Structure, regulation and function of PKB/AKT-A major therapeutic target. Biochim Biophys Acta 1697:3-16.
11. Jia L, Macey MG, Yin Y, Newland AC, Kelsey SM. 1999. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood 93:2353-2359.
12. Johnstone RW, Cretney E, Smyth MJ. 1999. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 93:1075-1085.
13. Lavrik IN, Golks A, Krammer PH. 2005. Caspases: Pharmacological manipulation of cell death. J Clin Invest 115:2665-2672.
14. Leslie EM, Deeley RG, Cole SPC. 2005. Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue difense. Toxicol Appl Pharmacol 204:216-237.
15. MacDonald HR, Bommhardt U, Cerottini JC. 1995. Developmentally regulated expression of P-glycoprotein (multidrug resistance) activity in mouse thymocytes. Eur J Immunol 25:1457-1460.
16. Mahadevan D, List AF. 2004. Targeting the multidrug resistance-1 transporter in AML: Molecular regulation and therapeutic strategies. Blood 104:1940-1951.
17. Martelli AM, Cappellini A, Tazzari PL, Billi AM, Tassi C, Ricci F, Fala F, Conte R. 2004. Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes. Haematologica 89:471-479.
18. Martelli AM, Tabellini G, Bortul R, Tazzari PL, Cappellini A, Billi AM, Cocco L. 2005. Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias. Histol Histopathol 20:239-252.
19. Matarrese P, Testa U, Cauda R, Vella S, Gambardella L, Malorni W. 2001. Expression of P-170 glycoprotein sensitizes lymphoblastoid CEM cells to mitochondria-mediated apoptosis. Biochem J 355:587-595.
20. Meschini S, Marra M, Calcabrini A, Federici E, Galeffi C, Arancia G. 2003. Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells. Int J Oncol 2003:1505-1513.
21. Nuti SL, Rao US. 2002. Proteolytic Cleavage of the linker region of the human P-glycoprotein modulates its ATPase function. J Biol Chem 277:29417-29423.
22. Nuti SL, Mehdi A, Rao US. 2000. Activation of P-glycoprotein ATPase by trypsin. Biochemistry 39:3424-3432.
23. Pervaiz S, Ramalingam JK, Hirpara JL, Clement MV. 1999. Superoxide anion inhibits drug-induced tumor cell death. FEBS Lett 459:343-348.
24. Ruefli AA, Tainton KM, Darcy PK, Smth MJ, Johnstone RW. 2002. P-glycoprotein inhibits caspase-8 activation but not the formation of the death inducine signal complex (disc) following Fas ligation. Cell Death Differ 9:1266-1272.
25. Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, van der Valk MA, Voordouw AC, Spits H, van Tellingen O, Zijlmans JM, Fibbe WE, Borst P. 1997. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 94:4028-4033.
26. Shah N, Asch RJ, Lysholm AS, Lebien TW. 2004. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Blood 104:2873-2878.
27. Slee EA, Adrain C, Martin SJ. 2001. Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276:7320-7326.
28. Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW. 1998. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci USA 95:7024-7029.
29. St Croix B, Kerbel RS. 1997. Cell adhesion and drug resistance in cancer. Curr Opin Oncol 9:549-556.
30. Tainton KM, Smyth MJ, Jackson JT, Tanner JE, Cerruti L, Jane SM, Darcy PK, Johnstone RW. 2004. Mutational analysis of P-glycoprotein: Suppression of caspase activation in the absence of ATP-dependent drug efflux. Cell Death Differ 11:1028-1037.
31. Thorburn A. 2004. Death receptor-induced cell killing. Cell Signal 16:139-144.
32. Tsuruo T, Naito M, Tomida A, Fujita N, Mashima T, Sakamoto H, Haga N. 2003. Molecular targeting therapy of cancer: Drug resistance, apoptosis and survival signal. Cancer Sci 94:15-21.
33. Uddin S, Hussein A, Al-Hussein K, Platanias LC, Bhatia KG. 2004. Inhibition of phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway. Biochem Biophys Res Commun 320:932-938.
34. Van Helvoort A, Smith AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P, van Meer G. 1996. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87: 507-517.