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Volumn 13, Issue 1, 2009, Pages 1-8

DNA damage in leukocytes from fanconi anemia (FA) patients and heterozygotes induced by mitomycin C and ionizing radiation as assessed by the comet and comet-FISH assay

Author keywords

Comet assay; DNA damage; Fanconi anemia patients; Gamma rays; Mitomycin C

Indexed keywords

FANCONI ANEMIA GROUP A PROTEIN; MITOMYCIN C;

EID: 65949088834     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (44)
  • 2
    • 0013772684 scopus 로고
    • Spontane chromosomenaberrationen bei familiärer Panmyelopathie
    • Schroeder, T.M., Anschutz, F. and Knopp, A. (1964) Spontane chromosomenaberrationen bei familiärer Panmyelopathie. Humangenetik 1: 194-196.
    • (1964) Humangenetik , vol.1 , pp. 194-196
    • Schroeder, T.M.1    Anschutz, F.2    Knopp, A.3
  • 3
    • 0015891353 scopus 로고
    • A high susceptibility of Fanconi?s anemia to chromosome breakage by DNA cross-linking agents
    • Sasaki, M.S. and Tonomura, A. (1973) A high susceptibility of Fanconi?s anemia to chromosome breakage by DNA cross-linking agents. Cancer Res. 33: 1829-1836.
    • (1973) Cancer Res , vol.33 , pp. 1829-1836
    • Sasaki, M.S.1    Tonomura, A.2
  • 4
    • 0017118656 scopus 로고
    • Susceptibility of Fanconi's anemia fibroblasts to chromosome damage by carcinogens
    • Auerbach, A.D. and Wolman, S.R. (1976) Susceptibility of Fanconi's anemia fibroblasts to chromosome damage by carcinogens. Nature 261: 494-496.
    • (1976) Nature , vol.261 , pp. 494-496
    • Auerbach, A.D.1    Wolman, S.R.2
  • 5
    • 0028950319 scopus 로고
    • Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia
    • Seyschab, H., Friedl, R., Sun, Y., Schindler, D., Hoehn, H., Hentze, S. and Schroeder-Kurth, T. (1995) Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia. Blood 8: 2233-2237.
    • (1995) Blood , vol.8 , pp. 2233-2237
    • Seyschab, H.1    Friedl, R.2    Sun, Y.3    Schindler, D.4    Hoehn, H.5    Hentze, S.6    Schroeder-Kurth, T.7
  • 6
    • 0023685747 scopus 로고
    • Fanconi anemia mutation causes cellular susceptibility to ambient oxygen
    • Schindler, D. and Hoehn, H. (1988) Fanconi anemia mutation causes cellular susceptibility to ambient oxygen. Am. J. Hum. Genet. 43: 429-435. (Pubitemid 18252915)
    • (1988) American Journal of Human Genetics , vol.43 , Issue.4 , pp. 429-435
    • Schindler, D.1    Hoehn, H.2
  • 7
    • 0031900748 scopus 로고    scopus 로고
    • Correlation between cellular radiosensitivity and non-repaired double- Strand breaks studied in nine mammalian cell lines
    • DOI 10.1080/095530098142365
    • Dikomey, E., Dahm-Daphi, J., Brammer, I., Martensen, R. and Kaina, B. (1998) Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int. J. Radiat. Biol. 73: 269-278. (Pubitemid 28160913)
    • (1998) International Journal of Radiation Biology , vol.73 , Issue.3 , pp. 269-278
    • Dikomey, E.1    Dahm-Daphi, J.2    Brammer, I.3    Martensen, R.4    Kaina, B.5
  • 8
    • 0034745675 scopus 로고    scopus 로고
    • Response to x-irradiation of fanconi anemia homozygous and heterozygous cells assessed by the single-cell gel electrophoresis (comet) assay
    • Djuzenova, C.S., Rothfuss, A., Oppitz, U., Speit, G., Schindle, D., Hoehn, H. and Flentje, M. (2001) Response to X-irradiation of Fanconi anemia homozygous and heterozygous cells assessed by the single-cell gel electrophoresis (Comet) assay. Lab. Invest. 81: 185-192. (Pubitemid 32176382)
    • (2001) Laboratory Investigation , vol.81 , Issue.2 , pp. 185-192
    • Djuzenova, C.S.1    Rothfuss, A.2    Oppitz, U.3    Speit, G.4    Schindler, D.5    Hoehn, H.6    Flentje, M.7
  • 9
    • 39049094697 scopus 로고    scopus 로고
    • Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation
    • Mohseni-Meybodi, A., Mozdarani, H. and Vosough, P. (2007) Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation. Cytogenet. Genome. Res. 119: 191-195.
    • (2007) Cytogenet. Genome. Res. , vol.119 , pp. 191-195
    • Mohseni-Meybodi, A.1    Mozdarani, H.2    Vosough, P.3
  • 10
    • 0034650339 scopus 로고    scopus 로고
    • Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families
    • Rothfuss, A., Schutz, P., Bochum, S., Volm, T., Eberhardt, E., Kreienberg, R., Vogel, W. and Speit, G. (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res. 60: 390-394. (Pubitemid 30070767)
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 390-394
    • Rothfuss, A.1    Schutz, P.2    Bochum, S.3    Volm, T.4    Eberhardt, E.5    Kreienberg, R.6    Vogel, W.7    Speit, G.8
  • 12
    • 0021193203 scopus 로고
    • Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells
    • Ostling, O. and Johanson, K.J. (1984) Micro electrophoretic study of radiation induced DNA damages in individual cells. Biochem. Biophys. Res.Commun. 123: 291-298. (Pubitemid 14030137)
    • (1984) Biochemical and Biophysical Research Communications , vol.123 , Issue.1 , pp. 291-298
    • Ostling, O.1    Johanson, K.J.2
  • 13
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175: 184-191. (Pubitemid 18100276)
    • (1988) Experimental Cell Research , vol.175 , Issue.1 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 15
  • 16
    • 0030580947 scopus 로고    scopus 로고
    • The comet assay: Mechanisms and technical considerations
    • Klaude, M., Eriksson, S., Nygren, J. and Ahnstrom, G. (1996) The comet assay: mechanisms and technical considerations. Mutat. Res. 363: 89-96.
    • (1996) Mutat. Res. , vol.363 , pp. 89-96
    • Klaude, M.1    Eriksson, S.2    Nygren, J.3    Ahnstrom, G.4
  • 17
    • 0028231896 scopus 로고
    • UV-B-laser-induced DNA damage in lymphocytes observed by single-cell gel electrophoresis
    • De With, A., Leitz, G. And Greulich, K.O. (1994) UV-B-laser-induced DNA damage in lymphocytes observed by single-cell gel electrophoresis. J. Photochem. Photobiol. B24: 47-53.
    • (1994) J. Photochem. Photobiol. , vol.B24 , pp. 47-53
    • De With, A.1    Leitz, G.2    Greulich, K.O.3
  • 18
    • 0031148618 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization with comets
    • DOI 10.1006/excr.1997.3555
    • Santos, S.J. Singh, N.P. and Natarajan. A.T. (1997) Fluorescence in situ hybridization with comets. Exp. Cell Res. 232: 407-411. (Pubitemid 27194056)
    • (1997) Experimental Cell Research , vol.232 , Issue.2 , pp. 407-411
    • Santos, S.J.1    Singh, N.P.2    Natarajan, A.T.3
  • 19
    • 0031962281 scopus 로고    scopus 로고
    • Emerging applications of the single cell gel electrophoresis (Comet) assay I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells
    • McKelvey-Martin, V.J., Ho, E.T., McKeown, S.R., Johnston, S.R., McCarthy, P.J. and Rajab, N.F. (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization comets for the identification of damaged and repaired DNA sequences in individual cells. Mutagenesis 13: 1-8.
    • (1998) Mutagenesis , vol.13 , pp. 1-8
    • McKelvey-Martin, V.J.1    Ho, E.T.2    McKeown, S.R.3    Johnston, S.R.4    McCarthy, P.J.5    Rajab, N.F.6
  • 20
    • 0031454867 scopus 로고    scopus 로고
    • Multicolor FISHing: What's the catch?
    • Lichter, P. (1997) Multicolor FISHing: what's the catch? Trends Genet. 13: 475-479.
    • (1997) Trends Genet. , vol.13 , pp. 475-479
    • Lichter, P.1
  • 21
    • 0032629329 scopus 로고    scopus 로고
    • Localisation of specific sequences and DNA single strand breaks in individual UV-A irradiated human lymphocytes observed by COMET FISH
    • Bock, C., Monajembashi, S., Rapp, A., Dittmar, H. and Greulich, K.O. (1999) Localisation of specific sequences and DNA single strand breaks in individual UV-A irradiated human lymphocytes observed by COMET FISH. Proc. SPIE 3568: 207-217.
    • (1999) Proc. SPIE , vol.3568 , pp. 207-217
    • Bock, C.1    Monajembashi, S.2    Rapp, A.3    Dittmar, H.4    Greulich, K.O.5
  • 22
    • 0007480063 scopus 로고    scopus 로고
    • COMET-FISH used to detect UV-A sensitive regions in the whole human genome and on chromosome 8
    • Rapp, A., Bock, H.C., Dittmar, H. and Greulich, K.O. (1999) COMET-FISH used to detect UV-A sensitive regions in the whole human genome and on chromosome 8. Neoplasma 46: 99-101.
    • (1999) Neoplasma , vol.46 , pp. 99-101
    • Rapp, A.1    Bock, H.C.2    Dittmar, H.3    Greulich, K.O.4
  • 23
    • 0033770352 scopus 로고    scopus 로고
    • UV-A breakage sensitivity of human chromosomes as measured by COMET-FISH depends on gene density and not on the chromosome size
    • Rapp, A., Bock, H.C., Dittmar, H. and Greulich, K.O. (2000) UV-A breakage sensitivity of human chromosomes as measured by COMET-FISH depends on gene density and not on the chromosome size. J. Photochem. Photobiol. B56: 109-117.
    • (2000) J. Photochem. Photobiol. , vol.56 , pp. 109-117
    • Rapp, A.1    Bock, H.C.2    Dittmar, H.3    Greulich, K.O.4
  • 25
    • 35148876225 scopus 로고    scopus 로고
    • Radiation sensitivity of leukocytes from healthy individuals and breast cancer patients as measured by the alkaline and neutral comet assay
    • DOI 10.1016/j.canlet.2007.08.002, PII S0304383507003473
    • Shahidi, M., Mozdarani, H. and Bryant, P.E. (2007) Radiation sensitivity of leukocytes from healthy individuals and breast cancer patients as measured by the alkaline and neutral comet assay. Cancer Lett. 257: 263-273. (Pubitemid 47538831)
    • (2007) Cancer Letters , vol.257 , Issue.2 , pp. 263-273
    • Shahidi, M.1    Mozdarani, H.2    Bryant, P.E.3
  • 26
    • 0030012151 scopus 로고    scopus 로고
    • Detection of DNA-Crosslinking agents with the alkaline comet assay
    • DOI 10.1002/(SICI)1098-2280(1996)27:3<196::AID-EM4>3.0.CO;2-D
    • Pfuhler, S., and Wolf, H.U. (1996) Detection of DNA-crosslinking agents with the alkaline comet assay. Environ. Mol. Mutagen. 27: 196-201. (Pubitemid 26152877)
    • (1996) Environmental and Molecular Mutagenesis , vol.27 , Issue.3 , pp. 196-201
    • Pfuhler, S.1    Wolf, H.U.2
  • 27
    • 0036497124 scopus 로고    scopus 로고
    • Bleomycin genotoxicity and amifostine (WR-2721) cell protection in normal leukocytes vs. K562 tumoral cells
    • DOI 10.1016/S0006-2952(01)00926-1, PII S0006295201009261
    • Buschini, A., Alessandrini, C., Martino, A., Pasini, L., Rizzoli, V., Carlo Stella, C., Poli, P. and Rossi, C. (2002) Bleomycin genotoxicity and amifostine (WR-2721) cell protection in normal leukocytes vs. K562 tumoral cells. Biochem. Pharmacol. 63: 967-975. (Pubitemid 34243010)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.5 , pp. 967-975
    • Buschini, A.1    Alessandrini, C.2    Martino, A.3    Pasini, L.4    Rizzoli, V.5    Carlo-Stella, C.6    Poli, P.7    Rossi, C.8
  • 28
    • 0344624874 scopus 로고    scopus 로고
    • Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay
    • DOI 10.1016/S0921-8777(97)00046-3, PII S0921877797000463
    • Jaloszynski, P., Kujawski, M., Czub-Swierczek, M., Markowska, J. and Szyfter, K. (1997) Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay. Mutat. Res. 385: 223-233. (Pubitemid 28097311)
    • (1997) Mutation Research - DNA Repair , vol.385 , Issue.3 , pp. 223-233
    • Jaloszynski, P.1    Kujawski, M.2    Czub-Swierczek, M.3    Janina, M.4    Szyfter, K.5
  • 29
    • 0000711137 scopus 로고
    • A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay
    • Kobayashi, H., Sugiyama, C., Morikawa, Y., Hayaashi, M. and Sofuni, T. (1995) A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay. MMS Commun. 3: 103-115. (Pubitemid 126029523)
    • (1995) Mammalian Mutagenicity Study Group Communications , vol.3 , Issue.2 , pp. 103-116
    • Kobayashi, H.1    Sugiyama, C.2    Morikawa, Y.3    Hayashi, M.4    Sofuni, T.5
  • 30
    • 0031049668 scopus 로고    scopus 로고
    • 2 and γ-irradiation
    • DOI 10.1016/S0921-8777(96)00047-X, PII S092187779600047X
    • Visvardis, E.E., Tassiou, A.M. and Piperakis, S.M. (1997) Study of DNA damage induction and repair capacity of fresh and cryo preserved lymphocytes exposed to H2O2 and gamma- irradiation with the alkaline comet assay. Mutat. Res. 383: 71-80. (Pubitemid 27063965)
    • (1997) Mutation Research - DNA Repair , vol.383 , Issue.1 , pp. 71-80
    • Visvardis, E.-E.1    Tassiou, A.M.2    Piperakis, S.M.3
  • 32
  • 33
  • 34
    • 0033602020 scopus 로고    scopus 로고
    • Organization of early and late replicating DNA in human chromosome territories
    • DOI 10.1006/excr.1998.4311
    • Zink, D., Bornfleth, H., Visser, A., Cremer, C. and Cremer, T. (1999) Organization of early and late replicating DNA in human chromosome territories, Exp. Cell Res. 247: 176-188. (Pubitemid 29393974)
    • (1999) Experimental Cell Research , vol.247 , Issue.1 , pp. 176-188
    • Zink, D.1    Bornfleth, H.2    Visser, A.3    Cremer, C.4    Cremer, T.5
  • 35
    • 0033853022 scopus 로고    scopus 로고
    • Contemporary management of superficial bladder cancer
    • Pow-Sang, J.M. and Seigne, J.D. (2000) Contemporary management of superficial bladder cancer. Cancer Control 7: 335-339. (Pubitemid 30602199)
    • (2000) Cancer Control , vol.7 , Issue.4 , pp. 335-339
    • Pow-Sang, J.M.1    Seigne, J.D.2
  • 37
    • 0034007114 scopus 로고    scopus 로고
    • Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay
    • Rajeswari, N., Ahuja, Y.R., Malini, U., Chandrashekar, S., Balakrishna, N., Rao, K.V. and Khar, A. (2000) Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay. Carcinogenesis 21: 557-561. (Pubitemid 30214006)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 557-561
    • Rajeswari, N.1    Ahuja, Y.R.2    Malini, U.3    Chandrashekar, S.4    Balakrishna, N.5    Rao, K.V.6    Khar, A.7
  • 38
    • 0014674689 scopus 로고
    • DNA strand breakings in cells irradiated with X-rays
    • Dean, C.T., Ormerod, M.G., Seriani, R.W. and Alexander, P. (1969) DNA strand breakings in cells irradiated with X-rays. Nature 222: 1042-1044.
    • (1969) Nature , vol.222 , pp. 1042-1044
    • Dean, C.T.1    Ormerod, M.G.2    Seriani, R.W.3    Alexander, P.4
  • 39
    • 0000695308 scopus 로고
    • Measurement of strand breaks by alkaline denaturation and hydroxylapatite chromatography
    • E.C. Friedberg, P.C. Hanawalt (Eds.), Marcel Dekker, New York
    • Ahnström, G. and Erixon, K. (1981) Measurement of strand breaks by alkaline denaturation and hydroxylapatite chromatography, in: E.C. Friedberg, P.C. Hanawalt (Eds.), DNA Repair (Part A), Marcel Dekker, New York, pp. 403-418.
    • (1981) DNA Repair (Part A) , pp. 403-418
    • Ahnström, G.1    Erixon, K.2
  • 40
    • 0033460329 scopus 로고    scopus 로고
    • The bromo deoxyuridine Comet assay: Detection of maturation of recently replicated DNA in individual cells
    • McGlynn, A.P., Wasson, G., O'Connor, J. McKerr, G., McKelvey-Martin, V.J. and Downes, C.S. (1999) The bromo deoxyuridine Comet assay: detection of maturation of recently replicated DNA in individual cells. Cancer Res. 59: 5912-5916.
    • (1999) Cancer Res , vol.59 , pp. 5912-5916
    • McGlynn, A.P.1    Wasson, G.2    O'Connor, J.3    McKerr, G.4    McKelvey-Martin, V.J.5    Downes, C.S.6
  • 42
    • 0032824901 scopus 로고    scopus 로고
    • Structural studies of atom-specific anticancer drugs acting on DNA
    • DOI 10.1016/S0163-7258(99)00020-0, PII S0163725899000200
    • Yang, X.L. and Wang, H.J. (1999) Structural studies on atom-specific anticancer drugs acting on DNA. Pharmacol. Ther. 83: 181-215. (Pubitemid 29430122)
    • (1999) Pharmacology and Therapeutics , vol.83 , Issue.3 , pp. 181-215
    • Yang, X.-L.1    Wang, A.H.-J.2
  • 43
    • 0142029127 scopus 로고    scopus 로고
    • Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells
    • McKenna, D.J., Gallus, M., McKeown, S.R., Downes, C.S. and McKelvey Martin, V.J. (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells. DNA Repair 2: 879-890.
    • (2003) DNA Repair , vol.2 , pp. 879-890
    • McKenna, D.J.1    Gallus, M.2    McKeown, S.R.3    Downes, C.S.4    McKelvey Martin, V.J.5
  • 44
    • 0032960477 scopus 로고    scopus 로고
    • Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity
    • DOI 10.1002/(SICI)1098-2280(1999)33:2<167::AID-EM9>3.0.CO;2-D
    • Merk, O. and Speit, G. (1999) Detection of crosslinks with the comet assay in relationship to genotoxicity and cytotoxicity. Environ. Mol. Mutagen. 33: 167-172. (Pubitemid 29172238)
    • (1999) Environmental and Molecular Mutagenesis , vol.33 , Issue.2 , pp. 167-172
    • Merk, O.1    Speit, G.2


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