메뉴 건너뛰기




Volumn 538, Issue , 2009, Pages 115-150

MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR

Author keywords

Acute lymphoblastic leukemia (ALL); IGH; IGK; IGL; Immunoglobulin (Ig); Junctional region; Minimal residual disease (MRD); Quantitative range; Real time quantitative PCR (RQ PCR); sensitivity; T cell receptor (TCR); TCRB; TCRD; TCRG

Indexed keywords

PRIMER DNA;

EID: 65649143517     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-418-6_7     Document Type: Article
Times cited : (91)

References (58)
  • 2
    • 0032572924 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group
    • Cave, H., van der Werff ten Bosch, J., Suciu, S., Guidal, C., Waterkeyn, C., Otten, J., Bakkus, M., Thielemans, K., Grandchamp, B., and Vilmer, E. (1998) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group. New England Journal of Medicine 339, 591-598.
    • (1998) New England Journal of Medicine , vol.339 , pp. 591-598
    • Cave, H.1    Van Der Werff Ten Bosch, J.2    Suciu, S.3    Guidal, C.4    Waterkeyn, C.5    Otten, J.6    Bakkus, M.7    Thielemans, K.8    Grandchamp, B.9    Vilmer, E.10
  • 4
    • 0034141517 scopus 로고    scopus 로고
    • Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia
    • Panzer-Grumayer, E. R., Schneider, M., Pan- zer, S., Fasching, K., and Gadner, H. (2000) Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia. Blood 95, 790-794. (Pubitemid 30062697)
    • (2000) Blood , vol.95 , Issue.3 , pp. 790-794
    • Panzer-Grumayer, E.R.1    Schneider, M.2    Panzer, S.3    Fasching, K.4    Gadner, H.5
  • 6
    • 0037768244 scopus 로고    scopus 로고
    • Risk-adapted therapy: Lessons from childhood acute lymphoblastic leukemia
    • Schrappe, M. (2002) Risk-adapted therapy: lessons from childhood acute lymphoblastic leukemia. Hematological Journal 3, 127-132.
    • (2002) Hematological Journal , vol.3 , pp. 127-132
    • Schrappe, M.1
  • 7
    • 0038040665 scopus 로고    scopus 로고
    • Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and laboratory aspects
    • DOI 10.1038/sj.leu.2402922
    • van der Velden, V. H. J., Hochhaus, A., Caz- zaniga, G., Szczepanski, T., Gabert, J., and van Dongen, J. J. M. (2003) Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects. Leukemia 17, 1013-1034. (Pubitemid 36722231)
    • (2003) Leukemia , vol.17 , Issue.6 , pp. 1013-1034
    • Van Der Velden, V.H.J.1    Hochhaus, A.2    Cazzaniga, G.3    Szczepanski, T.4    Gabert, J.5    Van Dongen, J.J.M.6
  • 8
    • 0036009608 scopus 로고    scopus 로고
    • Molecular monitoring of residual disease using antigen receptor genes in childhood acute lymphoblastic leukaemia. Best Practice & Research
    • Szczepanski, T., Flohr, T., van der Velden, V. H. J., Bartram, C. R., and van Dongen, J. J. M. (2002) Molecular monitoring of residual disease using antigen receptor genes in childhood acute lymphoblastic leukaemia. Best Practice & Research. Clinical Haematology 15, 37-57.
    • (2002) Clinical Haematology , vol.15 , pp. 37-57
    • Szczepanski, T.1    Flohr, T.2    Van Der Velden, V.H.J.3    Bartram, C.R.4    Van Dongen, J.J.M.5
  • 11
    • 18744433184 scopus 로고    scopus 로고
    • Classification systems for acute and chronic leukaemias. Best Practice & Research
    • Szczepanski, T., van der Velden, V. H., and van Dongen, J. J. (2003) Classification systems for acute and chronic leukaemias. Best Practice & Research. Clinical Haematology 16, 561-582.
    • (2003) Clinical Haematology , vol.16 , pp. 561-582
    • Szczepanski, T.1    Van Der Velden, V.H.2    Van Dongen, J.J.3
  • 12
    • 0031452746 scopus 로고    scopus 로고
    • Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations
    • Langerak, A. W., Szczepanski, T., van der Burg, M., Wolvers-Tettero, I. L., and van Dongen, J. J. (1997) Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations. Leukemia 11, 2192-2199. (Pubitemid 28043709)
    • (1997) Leukemia , vol.11 , Issue.12 , pp. 2192-2199
    • Langerak, A.W.1    Szczepanski, T.2    Van Der Burg, M.3    Wolvers-Tettero, I.L.M.4    Van Dongen, J.J.M.5
  • 13
    • 2342597048 scopus 로고    scopus 로고
    • Vδ2-Jα rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells
    • DOI 10.1182/blood-2003-08-2952
    • Szczepanski, T., van der Velden, V. H. J., Hoogeveen, P. G., De Bie, M., Jacobs, D. C. H., Van Wering, E. R., and van Dongen, J. J. M. (2004) V{delta}2-J{alpha} gene rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells. Blood 103, 3798-3804. (Pubitemid 38596298)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3798-3804
    • Szczepanski, T.1    Van Der Velden, V.H.J.2    Hoogeveen, P.G.3    De Bie, M.4    Jacobs, D.C.H.5    Van Wering, E.R.6    Van Dongen, J.J.M.7
  • 14
    • 17344367455 scopus 로고    scopus 로고
    • Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: Implications for selection of PCR targets for detection of minimal residual disease
    • Szczepanski, T., Langerak, A. W., Wolvers- Tettero, I. L., Ossenkoppele, G. J., Verhoef, G., Stul, M., Petersen, E. J., de Bruijn, M. A., van't Veer, M. B., and van Dongen, J. J. M. (1998) Immunoglobulin and T cell receptor gene rearrangement patterns in acute lym-phoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease. Leukemia 12, 1081-1088. (Pubitemid 28349804)
    • (1998) Leukemia , vol.12 , Issue.7 , pp. 1081-1088
    • Szczepanski, T.1    Langerak, A.W.2    Wolvers-Tettero, I.L.M.3    Ossenkoppele, G.J.4    Verhoef, G.5    Stul, M.6    Petersen, E.J.7    De Bruijn, M.A.C.8    Van't Veer, M.B.9    Van Dongen, J.J.M.10
  • 15
    • 0032996684 scopus 로고    scopus 로고
    • Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: Alternative PCR targets for detection of minimal residual disease
    • Szczepanski, T., Beishuizen, A., Pongers-Wil- lemse, M. J., Hahlen, K., Van Wering, E. R., Wijkhuijs, A. J., Tibbe, G. J., De Bruijn, M. A., and Van Dongen, J. J. M. (1999) Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease. Leukemia 13, 196-205. (Pubitemid 29092652)
    • (1999) Leukemia , vol.13 , Issue.2 , pp. 196-205
    • Szczepanski, T.1    Beishuizen, A.2    Pongers-Willemse, M.J.3    Hahlen, K.4    Van Wering, E.R.5    Wijkhuijs, A.J.M.6    Tibbe, G.J.M.7    De Bruijn, M.A.C.8    Van Dongen, J.J.M.9
  • 16
    • 0344654691 scopus 로고    scopus 로고
    • Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor αβ lineage
    • Szczepanski, T., Pongers-Willemse, M. J., Langerak, A. W., Harts, W. A., Wijkhuijs, A. J., van Wering, E. R., and van Dongen, J. J. M. (1999) Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage. Blood 93, 4079-4085. (Pubitemid 29279249)
    • (1999) Blood , vol.93 , Issue.12 , pp. 4079-4085
    • Szczepanski, T.1    Pongers-Willemse, M.J.2    Langerak, A.W.3    Harts, W.A.4    Wijkhuijs, A.J.M.5    Van Wering, E.R.6    Van Dongen, J.J.M.7
  • 17
    • 0034850655 scopus 로고    scopus 로고
    • H gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14
    • DOI 10.1038/sj.leu.2402206
    • Szczepanski, T., Willemse, M. J., van Wering, E. R., van Weerden, J. F., Kamps, W. A., and van Dongen, J. J. M. (2001) Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia 15, 1415-1423. (Pubitemid 32785311)
    • (2001) Leukemia , vol.15 , Issue.9 , pp. 1415-1423
    • Szczepanski, T.1    Willemse, M.J.2    Van Wering, E.R.3    Van Weerden, J.F.4    Kamps, W.A.5    Van Dongen, J.J.M.6
  • 20
    • 11144355827 scopus 로고    scopus 로고
    • Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia
    • DOI 10.1038/sj.leu.2403263
    • Bruggemann, M., van der Velden, V. H. J., Raff, T., Droese, J., Ritgen, M., Pott, C., Wijkhuijs, A., Goekbuget, N., Hoelzer, D., van Wering, E. R., van Dongen, J. J. M., and Kneba, M. (2004) Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease (MRD) in childhood and adult T-cell acute lymphoblastic leukemia (T-ALL). Leukemia 18, 709-719. (Pubitemid 38528651)
    • (2004) Leukemia , vol.18 , Issue.4 , pp. 709-719
    • Bruggemann, M.1    Van Der Velden, V.H.J.2    Raff, T.3    Droese, J.4    Ritgen, M.5    Pott, C.6    Wijkhuijs, A.J.7    Gokbuget, N.8    Hoelzer, D.9    Van Wering, E.R.10    Van Dongen, J.J.M.11    Kneba, M.12
  • 25
    • 33744469824 scopus 로고    scopus 로고
    • Immunoglobulin light chain gene rearrangements in precursor-B-acute lymphoblastic leukemia: Characteristics and applicability for the detection of minimal residual disease
    • van der Velden, V. H., de Bie, M., van Wering, E. R., and van Dongen, J. J. (2006) Immu-noglobulin light chain gene rearrangements in precursor-B-acute lymphoblastic leukemia: characteristics and applicability for the detection of minimal residual disease. Haematolog-ica 91, 679-682. (Pubitemid 43799469)
    • (2006) Haematologica , vol.91 , Issue.5 , pp. 679-682
    • Van Der Velden, V.H.J.1    De Bie, M.2    Van Wering, E.R.3    Van Dongen, J.J.M.4
  • 27
    • 0141725588 scopus 로고    scopus 로고
    • Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: Implications for detection of minimal residual disease
    • DOI 10.1038/sj.leu.2403038
    • Van Der Velden, V. H. J., Szczepanski, T., Wijkhuijs, J. M., Hart, P. G., Hoogeveen, P. G., Hop, W. C., Van Wering, E. R., and Van Dongen, J. J. M. (2003) Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: implications for detection of minimal residual disease. Leukemia 17, 1834-1844. (Pubitemid 37185260)
    • (2003) Leukemia , vol.17 , Issue.9 , pp. 1834-1844
    • Van Der Velden, V.H.J.1    Szczepanski, T.2    Wijkhuijs, J.M.3    Hart, P.G.4    Hoogeveen, P.G.5    Hop, W.C.J.6    Van Wering, E.R.7    Van Dongen, J.J.M.8
  • 28
    • 0036051771 scopus 로고    scopus 로고
    • T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis
    • van der Velden, V. H. J., Wijkhuijs, J. M., Jacobs, D. C., van Wering, E. R., and van Dongen, J. J. M. (2002) T cell receptor gamma gene rearrangements as targets for detection of minimal residual disease in acute lymphoblastic leukemia by real-time quantitative PCR analysis. Leukemia 16, 1372-1380.
    • (2002) Leukemia , vol.16 , pp. 1372-1380
    • Van Der Velden, V.H.J.1    Wijkhuijs, J.M.2    Jacobs, D.C.3    Van Wering, E.R.4    Van Dongen, J.J.M.5
  • 29
    • 0036114311 scopus 로고    scopus 로고
    • Immunoglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR
    • DOI 10.1038/sj.leu.2402475
    • van der Velden, V. H. J., Willemse, M. J., van der Schoot, C. E., Hahlen, K., van Wering, E. R., and van Dongen, J. J. M. (2002) Immu-noglobulin kappa deleting element rearrangements in precursor-B acute lymphoblastic leukemia are stable targets for detection of minimal residual disease by real-time quantitative PCR. Leukemia 16, 928-936. (Pubitemid 34537567)
    • (2002) Leukemia , vol.16 , Issue.5 , pp. 928-936
    • Van Der Velden, V.H.J.1    Willemse, M.J.2    Van Der Schoot, C.E.3    Hahlen, K.4    Van Wering, E.R.5    Van Dongen, J.J.M.6
  • 30
    • 0032919213 scopus 로고    scopus 로고
    • Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets. Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia
    • Pongers-Willemse, M. J., Seriu, T., Stolz, F., d'Aniello, E., Gameiro, P., Pisa, P., Gonzalez, M., Bartram, C. R., Panzer-Grumayer, E. R., Biondi, A., San Miguel, J. F., and van Dongen, J. J. M. (1999) Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. Leukemia 13, 110-118. (Pubitemid 29043725)
    • (1999) Leukemia , vol.13 , Issue.1 , pp. 110-118
    • Pongers-Willemse, M.J.1    Seriu, T.2    Stolz, F.3    D'Aniello, E.4    Gameiro, P.5    Pisa, P.6    Gonzalez, M.7    Bartram, C.R.8    Panzer-Grumayer, E.R.9    Biondi, A.10    San Miguel, J.F.11    Van Dongen, J.J.M.12
  • 31
    • 0027753103 scopus 로고
    • Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction
    • Kuppers, R., Zhao, M., Rajewsky, K., and Hansmann, M. L. (1993) Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. American Journal of Pathology 143, 230-239. (Pubitemid 24058177)
    • (1993) American Journal of Pathology , vol.143 , Issue.1 , pp. 230-239
    • Kuppers, R.1    Zhao, M.2    Rajewsky, K.3    Hansmann, M.L.4
  • 34
    • 0035128917 scopus 로고    scopus 로고
    • Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy
    • DOI 10.1038/sj.leu.2401970
    • de Haas, V., Verhagen, O. J., von dem Borne, A. E., Kroes, W., van den Berg, H., and van der Schoot, C. E. (2001) Quantification of minimal residual disease in children with oli-goclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy. Leukemia 15, 134-140. (Pubitemid 32140326)
    • (2001) Leukemia , vol.15 , Issue.1 , pp. 134-140
    • De Haas, V.1    Verhagen, O.J.H.M.2    Von Dem Borne, A.E.G.K.3    Kroes, W.4    Van Den Berg, H.5    Van Der Schoot, C.E.6
  • 35
    • 0037866469 scopus 로고    scopus 로고
    • Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: Evidence for the persistence of a preleukemic clone
    • DOI 10.1182/blood-2002-10-3252
    • Konrad, M., Metzler, M., Panzer, S., Ost- reicher, I., Peham, M., Repp, R., Haas, O. A., Gadner, H., and Panzer-Grumayer, E. R. (2003) Late relapses evolve from slow-re sponding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the per sistence of a preleukemic clone. Blood 101, 3635-3640. (Pubitemid 36857953)
    • (2003) Blood , vol.101 , Issue.9 , pp. 3635-3640
    • Konrad, M.1    Metzler, M.2    Panzer, S.3    Ostreicher, I.4    Peham, M.5    Repp, R.6    Haas, O.A.7    Gadner, H.8    Panzer-Grumayer, E.R.9
  • 36
    • 0025793311 scopus 로고
    • Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects
    • van Dongen, J. J. and Wolvers-Tettero, I. L. (1991) Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects. Clinical Chimica Acta 198, 1-91.
    • (1991) Clinical Chimica Acta , vol.198 , pp. 1-91
    • Van Dongen, J.J.1    Wolvers-Tettero, I.L.2
  • 37
    • 0344737645 scopus 로고    scopus 로고
    • Sequence analysis of clonal immunoglobulin and T-cell receptor gene rearrangements in children with acute lymphoblastic leukemia at diagnosis and at relapse: Implications for pathogenesis and for the clinical utility of PCR-based methods of minimal residual disease detection
    • DOI 10.1182/blood-2003-05-1455
    • Li, A., Zhou, J., Zuckerman, D., Rue, M., Dalton, V., Lyons, C., Silverman, L. B., Sal-lan, S. E., and Gribben, J. G. (2003) Sequence analysis of clonal immunoglobulin and T-cell receptor gene rearrangements in children with acute lymphoblastic leukemia at diagnosis and at relapse: implications for pathogenesis and for the clinical utility of PCR-based methods of minimal residual disease detection. Blood 102, 4520-4526. (Pubitemid 37494119)
    • (2003) Blood , vol.102 , Issue.13 , pp. 4520-4526
    • Li, A.1    Zhou, J.2    Zuckerman, D.3    Rue, M.4    Dalton, V.5    Lyons, C.6    Silverman, L.B.7    Sallan, S.E.8    Gribben, J.G.9
  • 38
    • 18244414473 scopus 로고    scopus 로고
    • Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurence of second T-ALL
    • DOI 10.1038/sj.leu.2403081
    • Szczepanski, T., van der Velden, V. H. J., Raff, T., Jacobs, D. C. H., van Wering, E. R., Brüggemann, M., Kneba, M., and van Dongen, J. J. M. (2003) Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphob-lastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurrence of secondary T-ALL. Leukemia 17, 2149-2156. (Pubitemid 37428380)
    • (2003) Leukemia , vol.17 , Issue.11 , pp. 2149-2156
    • Szczepanski, T.1    Van Der Velden, V.H.J.2    Raff, T.3    Jacobs, D.C.H.4    Van Wering, E.R.5    Bruggemann, M.6    Kneba, M.7    Van Dongen, J.J.M.8
  • 39
    • 0036530196 scopus 로고    scopus 로고
    • Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease
    • DOI 10.1182/blood.V99.7.2315
    • Szczepanski, T., Willemse, M. J., Brinkhof, B., van Wering, E. R., van der Burg, M., and van Dongen, J. J. M. (2002) Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-BALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease. Blood 99, 2315-2323. (Pubitemid 34525415)
    • (2002) Blood , vol.99 , Issue.7 , pp. 2315-2323
    • Szczeparnski, T.1    Willemse, M.J.2    Brinkhof, B.3    Van Wering, E.R.4    Van Der Burg, M.5    Van Dongen, J.J.M.6
  • 41
    • 0033902614 scopus 로고    scopus 로고
    • Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR
    • Br uggemann, M., Droese, J., Bolz, I., Luth, P., Pott, C., von Neuhof f, N., Scheuering, U., and Kneba, M. (2000) Improved assessment of minimal residual disease in B cell malignancies using fluorogenic consensus probes for real-time quantitative PCR. Leukemia 14, 1419-1425. (Pubitemid 30599323)
    • (2000) Leukemia , vol.14 , Issue.8 , pp. 1419-1425
    • Bruggemann, M.1    Droese, J.2    Bolz, I.3    Luth, P.4    Pott, C.5    Von Neuhoff, N.6    Scheuering, U.7    Kneba, M.8
  • 42
    • 0027723122 scopus 로고
    • Tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease
    • Breit, T. M., Beishuizen, A., Ludwig, W. D., Mol, E. J., Adriaansen, H. J., van Wering, E. R., and van Dongen, J. J. (1993) tal-1 deletions in T-cell acute lymphoblastic leukemia as PCR target for detection of minimal residual disease. Leukemia 7, 2004-2011. (Pubitemid 24003220)
    • (1993) Leukemia , vol.7 , Issue.12 , pp. 2004-2011
    • Breit, T.M.1    Beishuizen, A.2    Ludwig, W.-D.3    Mol, E.J.4    Adriaansen, H.J.5    Van Wering, E.R.6    Van Dongen, J.J.M.7
  • 43
    • 0027447707 scopus 로고
    • Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor α/β lineage: T cell receptor δ gene deletion mechanism affects multiple genes
    • Breit, T. M., Mol, E. J., Wolvers-Tettero, I. L., Ludwig, W. D., van Wering, E. R., and van Dongen, J. J. (1993) Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes. The Journal of Experimental Medicine 177, 965-977. (Pubitemid 23097386)
    • (1993) Journal of Experimental Medicine , vol.177 , Issue.4 , pp. 965-977
    • Breit, T.M.1    Mol, E.J.2    Wolvers-Tettero, I.L.M.3    Ludwig, W.-D.4    Van Wering, E.R.5    Van Dongen, J.J.M.6
  • 44
    • 0037768237 scopus 로고    scopus 로고
    • Real-time quantitative (RQ)-PCR for the detection of minimal residual disease in childhood acute lymphob-lastic leukemia
    • Szczepanski, T., van der Velden, V. H. J., and van Dongen, J. J. M. (2002) real-time quantitative (RQ)-PCR for the detection of minimal residual disease in childhood acute lymphob-lastic leukemia. Haematologica 87 (suppl. 1), 183-191.
    • (2002) Haematologica , vol.87 , Issue.SUPPL. 1 , pp. 183-191
    • Szczepanski, T.1    Van Der Velden, V.H.J.2    Van Dongen, J.J.M.3
  • 45
    • 0035889144 scopus 로고    scopus 로고
    • Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells
    • Langerak, A. W., Wolvers-Tettero, I. L., van Gastel-Mol, E. J., Oud, M. E., and van Dongen, J. J. (2001) Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells. Blood 98, 2456-2465.
    • (2001) Blood , vol.98 , pp. 2456-2465
    • Langerak, A.W.1    Wolvers-Tettero, I.L.2    Van Gastel-Mol, E.J.3    Oud, M.E.4    Van Dongen, J.J.5
  • 48
    • 0031760453 scopus 로고    scopus 로고
    • Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes
    • Pongers-Willemse, M. J., Verhagen, O. J., Tibbe, G. J., Wijkhuijs, A. J., de Haas, V., Roovers, E., van der Schoot, C. E., and van Dongen, J. J. M. (1998) Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes. Leukemia 12, 2006-2014. (Pubitemid 28554473)
    • (1998) Leukemia , vol.12 , Issue.12 , pp. 2006-2014
    • Pongers-Willemse, M.J.1    Verhagen, O.J.H.M.2    Tibbe, G.J.M.3    Wijkhuijs, A.J.M.4    De Haas, V.5    Roovers, E.6    Van Der School, C.E.7    Van Dongen, J.J.M.8
  • 49
    • 0027752682 scopus 로고
    • Detection of immunoglobulin heavy-chain gene rearrangements by Southern blot analysis: Recommendations for optimal results
    • Beishuizen, A., Verhoeven, M. A., Mol, E. J., Breit, T. M., Wolvers-Tettero, I. L., and van Dongen, J. J. (1993) Detection of immu-noglobulin heavy-chain gene rearrangements by Southern blot analysis: recommendations for optimal results. Leukemia 7, 2045-2053. (Pubitemid 24003226)
    • (1993) Leukemia , vol.7 , Issue.12 , pp. 2045-2053
    • Beishuizen, A.1    Verhoeven, M.-A.J.2    Mol, E.J.3    Breit, T.M.4    Wolvers-Tettero, I.L.M.5    Van Dongen, J.J.M.6
  • 50
    • 0028670764 scopus 로고
    • Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis
    • Beishuizen, A., Verhoeven, M. A., Mol, E. J., and van Dongen, J. J. (1994) Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis. Leukemia 8, 2228-2236.
    • (1994) Leukemia , vol.8 , pp. 2228-2236
    • Beishuizen, A.1    Verhoeven, M.A.2    Mol, E.J.3    Van Dongen, J.J.4
  • 51
    • 0027489873 scopus 로고
    • Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-δ gene rearrangements in acute lymphoblastic leukemia
    • Breit, T. M., Wolvers-Tettero, I. L., Beishui- zen, A., Verhoeven, M. A., van Wering, E. R., and van Dongen, J. J. (1993) Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia. Blood 82, 3063-3074. (Pubitemid 23334933)
    • (1993) Blood , vol.82 , Issue.10 , pp. 3063-3074
    • Breit, T.M.1    Wolvers-Tettero, I.L.M.2    Beishuizen, A.3    Verhoeven, M.-A.J.4    Van Wering, E.R.5    Van Dongen, J.J.M.6
  • 52
    • 17944374153 scopus 로고    scopus 로고
    • T-lymphocytes in bone marrow samples of children with acute lymphoblastic leukemia during and after chemotherapy might hamper PCR-based minimal residual disease studies (multiple letters) [1]
    • DOI 10.1038/sj.leu.2402184
    • van Wering, E. R., van der Linden-Schrever, B. E., van der Velden, V. H. J., Szczepanski, T., and van Dongen, J. J. M. (2001) T-lym-phocytes in bone marrow samples of children with acute lymphoblastic leukemia during and after chemotherapy might hamper PCR-based minimal residual disease studies. Leukemia 15, 1301-1303. (Pubitemid 32776457)
    • (2001) Leukemia , vol.15 , Issue.8 , pp. 1301-1303
    • Van Wering, E.R.1    Van Der Linden-Schrever, B.E.M.2    Van Der Velden, V.H.J.3    Szczepanski, T.4    Van Dongen, J.J.M.5
  • 54
    • 0034037006 scopus 로고    scopus 로고
    • Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy
    • van Lochem, E. G., Wiegers, Y. M., van den Beemd, R., Hahlen, K., van Dongen, J. J. M., and Hooijkaas, H. (2000) Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy. Leukemia 14, 688-695. (Pubitemid 30195461)
    • (2000) Leukemia , vol.14 , Issue.4 , pp. 688-695
    • Van Lochem, E.G.1    Wiegers, Y.M.2    Van Den Beemd, R.3    Hahlen, K.4    Van Dongen, J.J.M.5    Hooijkaas, H.6
  • 55
    • 40749122967 scopus 로고    scopus 로고
    • Non-specific amplification of patient-specific Ig/TCR gene rearrangements depends on the time point during therapy: Implications for minimal residual disease monitoring [5]
    • DOI 10.1038/sj.leu.2404925, PII 2404925
    • Van der Velden, V. H. J., Wijkhuijs, J. M., and Van Dongen, J. J. M. (2008) Non-specific amplification of patient-specific Ig/TCR gene rearrangements depends on the time point during therapy: implications for minimal residual disease monitoring. Leukemia 22, 641-644. (Pubitemid 351386738)
    • (2008) Leukemia , vol.22 , Issue.3 , pp. 641-644
    • Van Der Velden, V.H.J.1    Wijkhuijs, J.M.2    Van Dongen, J.J.M.3
  • 56
    • 33645834105 scopus 로고    scopus 로고
    • Impact of two independent bone marrow samples on minimal residual disease monitoring in childhood acute lymphoblastic leukaemia
    • van der Velden, V. H., Hoogeveen, P. G., Pieters, R., and van Dongen, J. J. (2006) Impact of two independent bone marrow samples on minimal residual disease monitoring in childhood acute lymphoblastic leukaemia. British Journal of Haematolology 133, 382-388.
    • (2006) British Journal of Haematolology , vol.133 , pp. 382-388
    • Van Der Velden, V.H.1    Hoogeveen, P.G.2    Pieters, R.3    Van Dongen, J.J.4
  • 57
    • 0036050143 scopus 로고    scopus 로고
    • Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL
    • van der Velden, V. H. J., Jacobs, D. C., Wijkhuijs, A. J., Comans-Bitter, W. M., Wil-lemse, M. J., Hahlen, K., Kamps, W. A., van Wering, E. R., and van Dongen, J. J. M. (2002) Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL. Leukemia 16, 1432-1436.
    • (2002) Leukemia , vol.16 , pp. 1432-1436
    • Van Der Velden, V.H.J.1    Jacobs, D.C.2    Wijkhuijs, A.J.3    Comans-Bitter, W.M.4    Wil-Lemse, M.J.5    Hahlen, K.6    Kamps, W.A.7    Van Wering, E.R.8    Van Dongen, J.J.M.9
  • 58
    • 0037266197 scopus 로고    scopus 로고
    • Inhibition affecting RQ-PCR-based assessment of minimal residual disease in acute lymphoblastic leukemia: Reversal by addition of bovine serum albumin [2]
    • DOI 10.1038/sj.leu.2402751
    • Moppett, J., van der Velden, V. H., Wijkhuijs, A. J., Hancock, J., van Dongen, J. J., and Goulden, N. (2003) Inhibition affecting RQ-PCR-based assessment of minimal residual disease in acute lymphoblastic leukemia: Reversal by addition of bovine serum albumin. Leukemia 17, 268-270. (Pubitemid 36175921)
    • (2003) Leukemia , vol.17 , Issue.1 , pp. 268-270
    • Moopett, J.1    Van Der Velden, V.H.J.2    Wijkhuijs, A.J.M.3    Hancock, J.4    Van Dongen, J.J.M.5    Gouden, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.