Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: A new molecular target for detection of minimal residual disease

Leukemia

Volumn 11, Issue 12, 1997, Pages 2200-2207

  Beishuizen, A ^a   De Bruijn, M A C ^a   Pongers Willemse, M J ^a   Verhoeven, M A J ^a   Van Wering, E R ^b   Hahlen K ^b,c   Breit, T M ^a   De Bruin Versteeg, S ^a   Hooijkaas, H ^a   Van Dongen, J J M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

B lineage leukemias; IGK genes; Kappa deleting element (Kde); MRD; Precursor B ALL; Rearrangements

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; GENE DELETION; GENE INSERTION; GENE REARRANGEMENT; GENETIC HETEROGENEITY; IMMUNOGLOBULIN GENE; MINIMAL RESIDUAL DISEASE; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 17144462838     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400904     Document Type: Article

References (20)

1. Van Dongen JJM, Adriaansen HJ, Hooijkaas H. Immunophenotyping of leukemias and non-Hodgkin lymphomas: immunological markers and their CD codes. Neth J Med 1988; 33: 298-314.
2. Van Dongen JJM, Wolvers-Tettero ILM. Analysis of immunoglobulin and T cell receptor genes. Part II: possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders. Clin Chim Acta 1991; 198: 93-174.
3. Felix CA, Poplack DG. Characterization of acute lymphoblastic leukemia of childhood by immunoglobulin and T-cell receptor gene patterns. Leukemia 1991; 5: 1015-1025.
4. Beishuizen A, Hählen K, Hagemeijer A, Verhoeveh M-AJ, Hooijkaas H, Adriaansen HJ, Wolvers-Tettero ILM, Van Wering ER, Van Dongen JJM. Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor-B-cell origin. Leukemia 1991; 5: 657-667.
5. Lenormand B, Ghanem N, Tilly H, Boussemort C, Monconduit M, Piguet H, LeFranc G, LeFranc M-P. Rearrangements of immunoglobulin light and heavy chain genes and correlation with phenotypic markers in B cell chronic lymphocytic leukemia. Leukemia 1991; 5: 928-936.
6. Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells. Nature 1981; 290: 368-372.
7. Siminovitch KA, Bakhshi A, Goldman P, Korsmeyer SJ. A uniform deleting element mediates the loss of κ genes in human B cells. Nature 1985; 316: 260-262.
8. Klobeck HG, Zachau HG. The human Cκ gene segment and the kappa deleting element are closely linked. Nucleic Acid Res 1986; 14: 4591-4603.
9. Siminovitch KA, Moore MW, Durdik J, Selsing E. The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res 1987; 15: 2699-2705.
10. Graninger WB, Goldman PL, Morton CC, O'Brien SJ, Korsmeyer SJ. The κ-deleting element: germline and rearranged, duplicated and dispersed forms. J Exp Med 1988; 167: 488-501.
11. Beishuizen A, Verhoeven M-AJ, Mol EJ, Van Dongen JJM. Detection of immunoglobulin kappa light-chain gene rearrangement patterns by Southern blot analysis. Leukemia 1994; 8: 2228-2236.
12. Schäble KF, Zachau HG. The variable genes of the human immunoglobulin κ locus. Biol Chem Hoppe-Seyler 1993; 374: 1001-1022.
13. Schäble KF, Thiebe R, Flügel A, Meindl A, Zachau HG. The human immunoglobulin κ locus: pseudogenes, unique and repetitive sequences. Biol Chem Hoppe-Seyler 1994; 375: 189-199.
14. Weichold GM, Ohnheiser R, Zachau HG. The human immunoglobulin κ locus cosists of two copies that are organized in opposite polarity. Genomics 1993; 16: 503-511.
15. Davis MM, Björkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334: 395-402.
16. Van Dongen JJM, Wolvers-Tettero ILM. Analysis of immunoglobulin and T-cell receptor genes. Part I: basic and technical aspects. Clin Chim Acta 1991; 198: 1-91.
17. Schatz DG, Oettinger MA, Schlissel MS. V(D)J recombination: molecular biology and regulation. Annu Rev Immunol 1992; 10: 359-383.
18. Lieber MR. The role of site-directed recombinases in physiologic and pathologic chromosomal rearrangements. In: Kirsch IR (ed). The Causes and Consequences of Chromosomal Aberrations. CRC Press: Boca Raton, FL, 1993, pp 240-275.
19. H fusions. Proc Natl Acad Sci USA 1982; 79: 4118-4122.
20. Lafaille JJ, DeCloux A, Bonneville M, Takagaki Y, Tonegawa S. Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 1989; 59: 859-870.