Acute lymphoblastic leukemia with t(4;11) in children 1 year and older: The 'big sister' of the infant disease?

Leukemia

Volumn 21, Issue 4, 2007, Pages 642-646

  Mann, G ^a   Cazzaniga, G ^b   van der Velden, V H J ^c   Flohr, T ^d   Csinady, E ^e   Paganin, M ^f   Schrauder, A ^d   Dohnal, A M ^e   Schrappe, M ^d   Biondi, A ^b   Gadner, H ^a,e   van Dongen, J J M ^c   Panzer Grumayer E R ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^f UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MIXED LINEAGE LEUKEMIA AF4 PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN MLL AF4; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ALLELE; ARTICLE; CELL MATURATION; CHILD; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 4; CLINICAL ARTICLE; GENE AMPLIFICATION; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENE REARRANGEMENT; GENETIC TRANSFORMATION; HUMAN; IMMUNOPHENOTYPING; PRE B LYMPHOCYTE; PRIORITY JOURNAL;

EID: 33947430189     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404577     Document Type: Article

References (32)

1. Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001; 20: 5695-5707.
2. Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S et al. The MLL recombinome of acute leukemias. Leukemia 2006; 20: 777-784.
3. Mieke WJC, Jansen LC, Vincent HJ, van der V, Renate P-G, Martin S et al. Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement. Leukemia (in press).
4. Pui CH, Kane JR, Crist WM. Biology and treatment of infant leukemias. Leukemia 1995; 9: 762-769.
5. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006; 354: 166-178.
6. Cheok MH, Evans WE. Acute lymphoblastic leukaemia: A model for the pharmacogenomics of cancer therapy. Nat Rev Cancer 2006; 6: 117-129.
7. Behm FG, Raimondi SC, Frestedt JL, Liu Q, Crist WM, Downing JR et al. Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age. Blood 1996; 87: 2870-2877.
8. Pui CH, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W et al. Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 2002; 359: 1909-1915.
9. Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17: 700-706.
10. Biondi A, Cimino G, Pieters R, Pui CH. Biological and therapeutic aspects of infant leukemia. Blood 2000; 96: 24-33.
11. Reichel M, Gillert E, Angermuller S, Hensel JP, Heidel F, Lode M et al. Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL. Oncogene 2001; 20: 2900-2907.
12. Pongers-Willemse MJ, Seriu T, Stolz F, d'Aniello E, Gameiro P, Pisa P et al. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: Report of the BIOMED-1 CONCERTED ACTION: Investigation of minimal residual disease in acute leukemia. Leukemia 1999; 13: 110-118.
13. Szczepanski T, Flohr T, van der Velden VH, Bartram CR, van Dongen JJ. Molecular monitoring of residual disease using antigen receptor genes in childhood acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 2002; 15: 37-57.
14. Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J. VDJ recombination. Immunol Today 1992; 13: 306-314.
15. van Zelm MC, van der Burg M, de Ridder D, Barendregt BH, de Haas EF, Reinders MJ et al. Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol 2005; 175: 5912-5922.
16. van der Burg M, Barendregt BH, Szczepanski T, van Wering ER, Langerak AW, van Dongen JJ. Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL. Leukemia 2002; 16: 1448-1453.
17. Hubner S, Cazzaniga G, Flohr T, van der Velden VH, Konrad M, Potschger U et al. High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias. Leukemia 2004; 18: 84-91.
18. Brumpt C, Delabesse E, Beldjord K, Davi F, Cayuela JM, Millien C et al. The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood 2000; 96: 2254-2261.
19. van der Velden VH, Szczepanski T, Wijkhuijs JM, Hart PG, Hoogeveen PG, Hop WC et al. Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: Implications for detection of minimal residual disease. Leukemia 2003; 17: 1834-1844.
20. Schrappe M. Evolution of BFM trials for childhood ALL. Ann Hematol 2004; 83 (Suppl 1): S121-S123.
21. van der Does-van den Berg A, Bartram CR, Basso G, Benoit YC, Biondi A, Debatin KM et al. Minimal requirements for the diagnosis, classification, and evaluation of the treatment of childhood acute lymphoblastic leukemia (ALL) in the 'BFM Family' Cooperative Group. Med Pediatr Oncol 1992; 20: 497-505.
22. Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003; 17: 2318-2357.
23. van der Burg M, Poulsen TS, Hunger SP, Beverloo HB, Smit EM, Vang-Nielsen K et al. Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia. Leukemia 2004; 18: 895-908.
24. Schrappe M, Reiter A, Ludwig WD, Harbott J, Zimmermann M, Hiddemann W et al. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group Blood 2000; 95: 3310-3322.
25. Steenbergen EJ, Verhagen OJ, van Leeuwen EF, Behrendt H, Merle PA, Wester MR et al. B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased recombination repertoire: Leukemic transformation frequently occurs in fetal life. Eur J Immunol 1994; 24: 900-908.
26. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT et al. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2002; 99: 15101-15106.
27. Steenbergen EJ, Verhagen OJ, van den Berg H, van Leeuwen EF, Behrendt H, Slater RR et al. Rearrangement status of the malignant cell determines type of secondary IgH rearrangement (V-replacement or V to DJ joining) in childhood B precursor acute lymphoblastic leukemia. Leukemia 1997; 11: 1258-1265.
28. Hagemeijer A, van Dongen JJ, Slater RM, van't Veer MB, Behrendt H, Hahlen K et al. Characterization of the blast cells in acute leukemia with translocation (4;11): Report of eight additional cases and of one case with a variant translocation. Leukemia 1987; 1: 24-31.
29. Moneypenny CG, Shao J, Song Y, Gallagher EP. MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis 2006; 27: 874-881.
30. Eguchi M, Eguchi-Ishimae M, Knight D, Kearney L, Slany R, Greaves M. MLL chimeric protein activation renders cells vulnerable to chromosomal damage: An explanation for the very short latency of infant leukemia. Genes Chromosomes Cancer 2006; 45: 754-760.
31. Fasching K, Panzer S, Haas OA, Borkhardt A, Marschalek R, Griesinger F et al. Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia. Blood 2001; 98: 2272-2274.
32. Bertrand FE, Vogtenhuber C, Shah N, LeBien TW. Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/ AF4 fusion protein. Blood 2001; 98: 3398-3405.